Tyrosine-protein phosphatase non-receptor type 2

NameTyrosine-protein phosphatase non-receptor type 2
Synonyms3.1.3.48 PTPT T-cell protein-tyrosine phosphatase TCPTP
Gene NamePTPN2
OrganismHuman
Amino acid sequence
>lcl|BSEQ0009001|Tyrosine-protein phosphatase non-receptor type 2
MPTTIEREFEELDTQRRWQPLYLEIRNESHDYPHRVAKFPENRNRNRYRDVSPYDHSRVK
LQNAENDYINASLVDIEEAQRSYILTQGPLPNTCCHFWLMVWQQKTKAVVMLNRIVEKES
VKCAQYWPTDDQEMLFKETGFSVKLLSEDVKSYYTVHLLQLENINSGETRTISHFHYTTW
PDFGVPESPASFLNFLFKVRESGSLNPDHGPAVIHCSAGIGRSGTFSLVDTCLVLMEKGD
DINIKQVLLNMRKYRMGLIQTPDQLRFSYMAIIEGAKCIKGDSSIQKRWKELSKEDLSPA
FDHSPNKIMTEKYNGNRIGLEEEKLTGDRCTGLSSKMQDTMEENSESALRKRIREDRKAT
TAQKVQQMKQRLNENERKRKRWLYWQPILTKMGFMSVILVGAFVGWTLFFQQNAL
Number of residues415
Molecular Weight48472.94
Theoretical pINone
GO Classification
Functions
    integrin binding
protein kinase binding
receptor tyrosine kinase binding
protein tyrosine phosphatase activity
syntaxin binding
Processes
    negative regulation of tumor necrosis factor-mediated signaling pathway
negative regulation of T cell receptor signaling pathway
negative regulation of cell proliferation
negative regulation of positive thymic T cell selection
negative regulation of insulin receptor signaling pathway
T cell differentiation
negative regulation of inflammatory response
negative regulation of prolactin signaling pathway
peptidyl-tyrosine dephosphorylation
positive regulation of gluconeogenesis
cytokine-mediated signaling pathway
negative regulation of type I interferon-mediated signaling pathway
erythrocyte differentiation
negative regulation of tyrosine phosphorylation of Stat5 protein
negative regulation of macrophage differentiation
negative regulation of interferon-gamma-mediated signaling pathway
negative regulation of chemotaxis
negative regulation of tyrosine phosphorylation of Stat6 protein
negative regulation of epidermal growth factor receptor signaling pathway
interferon-gamma-mediated signaling pathway
positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway
negative regulation of lipid storage
regulation of hepatocyte growth factor receptor signaling pathway
regulation of interferon-gamma-mediated signaling pathway
positive regulation of PERK-mediated unfolded protein response
negative regulation of tyrosine phosphorylation of Stat3 protein
negative regulation of platelet-derived growth factor receptor-beta signaling pathway
glucose homeostasis
negative regulation of interleukin-6-mediated signaling pathway
negative regulation of interleukin-2-mediated signaling pathway
B cell differentiation
negative regulation of tyrosine phosphorylation of Stat1 protein
negative regulation of interleukin-4-mediated signaling pathway
negative regulation of ERK1 and ERK2 cascade
negative regulation of protein tyrosine kinase activity
insulin receptor signaling pathway
negative regulation of macrophage colony-stimulating factor signaling pathway
Components
    nucleus
endoplasmic reticulum
plasma membrane
endoplasmic reticulum-Golgi intermediate compartment
nucleoplasm
General FunctionSyntaxin binding
Specific FunctionNon-receptor type tyrosine-specific phosphatase that dephosphorylates receptor protein tyrosine kinases including INSR, EGFR, CSF1R, PDGFR. Also dephosphorylates non-receptor protein tyrosine kinases like JAK1, JAK2, JAK3, Src family kinases, STAT1, STAT3, STAT5A, STAT5B and STAT6 either in the nucleus or the cytoplasm. Negatively regulates numerous signaling pathways and biological processes like hematopoiesis, inflammatory response, cell proliferation and differentiation, and glucose homeostasis. Plays a multifaceted and important role in the development of the immune system. Functions in T-cell receptor signaling through dephosphorylation of FYN and LCK to control T-cells differentiation and activation. Dephosphorylates CSF1R, negatively regulating its downstream signaling and macrophage differentiation. Negatively regulates cytokine (IL2/interleukin-2 and interferon)-mediated signaling through dephosphorylation of the cytoplasmic kinases JAK1, JAK3 and their substrate STAT1, that propagate signaling downstream of the cytokine receptors. Also regulates the IL6/interleukin-6 and IL4/interleukin-4 cytokine signaling through dephosphorylation of STAT3 and STAT6 respectively. In addition to the immune system, it is involved in anchorage-dependent, negative regulation of EGF-stimulated cell growth. Activated by the integrin ITGA1/ITGB1, it dephosphorylates EGFR and negatively regulates EGF signaling. Dephosphorylates PDGFRB and negatively regulates platelet-derived growth factor receptor-beta signaling pathway and therefore cell proliferation. Negatively regulates tumor necrosis factor-mediated signaling downstream via MAPK through SRC dephosphorylation. May also regulate the hepatocyte growth factor receptor signaling pathway through dephosphorylation of the hepatocyte growth factor receptor MET. Plays also an important role in glucose homeostasis. For instance, negatively regulates the insulin receptor signaling pathway through the dephosphorylation of INSR and control gluconeogenesis and liver glucose production through negative regulation of the IL6 signaling pathways. Finally, it negatively regulates prolactin-mediated signaling pathway through dephosphorylation of STAT5A and STAT5B. May also bind DNA.
Transmembrane Regions
GenBank Protein ID
UniProtKB IDP17706
UniProtKB Entry NamePTN2_HUMAN
Cellular LocationEndoplasmic reticulum
Gene sequence
>lcl|BSEQ0020842|Tyrosine-protein phosphatase non-receptor type 2 (PTPN2)
ATGCCCACCACCATCGAGCGGGAGTTCGAAGAGTTGGATACTCAGCGTCGCTGGCAGCCG
CTGTACTTGGAAATTCGAAATGAGTCCCATGACTATCCTCATAGAGTGGCCAAGTTTCCA
GAAAACAGAAATCGAAACAGATACAGAGATGTAAGCCCATATGATCACAGTCGTGTTAAA
CTGCAAAATGCTGAGAATGATTATATTAATGCCAGTTTAGTTGACATAGAAGAGGCACAA
AGGAGTTACATCTTAACACAGGGTCCACTTCCTAACACATGCTGCCATTTCTGGCTTATG
GTTTGGCAGCAGAAGACCAAAGCAGTTGTCATGCTGAACCGCATTGTGGAGAAAGAATCG
GTTAAATGTGCACAGTACTGGCCAACAGATGACCAAGAGATGCTGTTTAAAGAAACAGGA
TTCAGTGTGAAGCTCTTGTCAGAAGATGTGAAGTCGTATTATACAGTACATCTACTACAA
TTAGAAAATATCAATTATATTGAGAACTTGTGGATCACACTGTATTTGAAATTATTAATG
CTGGATGTTAAAAGGTCACTAAAAAGTGGTGAAACCAGAACAATATCTCACTTTCATTAT
ACTACCTGGCCAGATTTTGGAGTCCCTGAATCACCAGCTTCATTTCTCAATTTCTTGTTT
AAAGTGAGAGAATCTGGCTCCTTGAACCCTGACCATGGGCCTGCGGTGATCCACTGTAGT
GCAGGCATTGGGCGCTCTGGCACCTTCTCTCTGGTAGACACTTGTCTTGTTTTGATGGAA
AAAGGAGATGATATTAACATAAAACAAGTGTTACTGAACATGAGAAAATACCGAATGGGT
CTTATTCAGACCCCAGATCAACTGAGATTCTCATACATGGCTATAATAGAAGGAGCAAAA
TGTATAAAGGGAGATTCTAGTATACAGAAACGATGGAAAGAACTTTCTAAGGAAGACTTA
TCTCCTGCCTTTGATCATTCACCAAACAAAATAATGACTGAAAAATACAATGGGAACAGA
ATAGGTCTAGAAGAAGAAAAACTGACAGGTGACCGATGTACAGGACTTTCCTCTAAAATG
CAAGATACAATGGAGGAGAACAGTGAGAGTGCTCTACGGAAACGTATTCGAGAGGACAGA
AAGGCCACCACAGCTCAGAAGGTGCAGCAGATGAAACAGAGGCTAAATGAGAATGAACGA
AAAAGAAAAAGGCCAAGATTGACAGACACCTAA
GenBank Gene ID
GeneCard IDNone
GenAtlas ID
HGNC IDHGNC:9650
Chromosome Location18
LocusNone
References
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