3-oxo-5-alpha-steroid 4-dehydrogenase 1
Name | 3-oxo-5-alpha-steroid 4-dehydrogenase 1 |
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Synonyms | 1.3.1.22 S5AR 1 SR type 1 Steroid 5-alpha-reductase 1 |
Gene Name | SRD5A1 |
Organism | Human |
Amino acid sequence | >lcl|BSEQ0010375|3-oxo-5-alpha-steroid 4-dehydrogenase 1 MATATGVAEERLLAALAYLQCAVGCAVFARNRQTNSVYGRHALPSHRLRVPARAAWVVQE LPSLALPLYQYASESAPRLRSAPNCILLAMFLVHYGHRCLIYPFLMRGGKPMPLLACTMA IMFCTCNGYLQSRYLSHCAVYADDWVTDPRFLIGFGLWLTGMLINIHSDHILRNLRKPGD TGYKIPRGGLFEYVTAANYFGEIMEWCGYALASWSVQGAAFAFFTFCFLSGRAKEHHEWY LRKFEEYPKFRKIIIPFLF |
Number of residues | 259 |
Molecular Weight | 29458.18 |
Theoretical pI | 9.07 |
GO Classification |
Functions
3-oxo-5-alpha-steroid 4-dehydrogenase activity cholestenone 5-alpha-reductase activity electron carrier activity Processes
small molecule metabolic process cell differentiation steroid metabolic process androgen biosynthetic process sex determination sex differentiation Components
endoplasmic reticulum membrane integral component of membrane |
General Function | Electron carrier activity |
Specific Function | Converts testosterone into 5-alpha-dihydrotestosterone and progesterone or corticosterone into their corresponding 5-alpha-3-oxosteroids. It plays a central role in sexual differentiation and androgen physiology. |
Transmembrane Regions | 12-29 86-106 111-131 151-171 209-229 |
GenBank Protein ID | 177767 |
UniProtKB ID | P18405 |
UniProtKB Entry Name | S5A1_HUMAN |
Cellular Location | Microsome membrane |
Gene sequence | >lcl|BSEQ0010376|3-oxo-5-alpha-steroid 4-dehydrogenase 1 (SRD5A1) ATGGCAACGGCGACGGGGGTGGCGGAGGAGCGCCTGCTGGCCGCGCTCGCCTACCTGCAG TGCGCCGTGGGCTGCGCGGTCTTCGCGCGCAATCGTCAGACGAACTCAGTGTACGGCCGC CACGCGCTGCCCAGCCACAGGCTCCGAGTGCCGGCGCGGGCCGCCTGGGTGGTGCAGGAG CTGCCCTCGCTGGCCCTGCCGCTCTACCAGTACGCCAGCGAGTCCGCCCCGCGTCTCCGC AGCGCGCCCAACTGCATCCTCCTGGCCATGTTCCTCGTCCACTACGGGCATCGGTGCTTA ATTTACCCATTTCTGATGCGAGGAGGAAAGCCTATGCCACTGTTGGCGTGTACAATGGCG ATTATGTTCTGTACCTGTAACGGCTATTTGCAAAGCAGATACTTGAGCCATTGTGCAGTG TATGCTGATGACTGGGTAACAGATCCCCGTTTTCTAATAGGTTTTGGCTTGTGGTTAACG GGCATGTTGATAAACATCCATTCAGATCATATCCTAAGGAATCTCAGAAAACCAGGAGAT ACTGGATACAAAATACCAAGGGGAGGCTTATTTGAATACGTAACTGCAGCCAACTATTTT GGAGAAATCATGGAGTGGTGTGGCTATGCCCTGGCCAGCTGGTCTGTCCAAGGCGCGGCT TTTGCTTTCTTCACGTTTTGTTTTTTATCTGGTAGAGCAAAAGAGCATCATGAGTGGTAC CTCCGGAAATTTGAAGAGTATCCAAAGTTCAGAAAAATTATAATTCCATTTTTGTTTTAA |
GenBank Gene ID | M32313 |
GeneCard ID | None |
GenAtlas ID | SRD5A1 |
HGNC ID | HGNC:11284 |
Chromosome Location | 5 |
Locus | 5p15 |
References |
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Related FRC
FRCD ID | Name | Exact Mass | Structure |
---|---|---|---|
Finasteride |
372.553 |