DNA-directed RNA polymerases I, II, and III subunit RPABC1
Name | DNA-directed RNA polymerases I, II, and III subunit RPABC1 |
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Synonyms | DNA-directed RNA polymerase II 23 kDa polypeptide DNA-directed RNA polymerase II subunit E RNA polymerases I, II, and III subunit ABC1 RPB5 homolog XAP4 |
Gene Name | POLR2E |
Organism | Human |
Amino acid sequence | >lcl|BSEQ0012582|DNA-directed RNA polymerases I, II, and III subunit RPABC1 MDDEEETYRLWKIRKTIMQLCHDRGYLVTQDELDQTLEEFKAQSGDKPSEGRPRRTDLTV LVAHNDDPTDQMFVFFPEEPKVGIKTIKVYCQRMQEENITRALIVVQQGMTPSAKQSLVD MAPKYILEQFLQQELLINITEHELVPEHVVMTKEEVTELLARYKLRENQLPRIQAGDPVA RYFGIKRGQVVKIIRPSETAGRYITYRLVQ |
Number of residues | 210 |
Molecular Weight | 24551.075 |
Theoretical pI | 5.76 |
GO Classification |
Functions
DNA binding DNA-directed RNA polymerase activity Processes
transcription initiation from RNA polymerase II promoter gene silencing by RNA transcription elongation from RNA polymerase III promoter mRNA splicing, via spliceosome transcription from RNA polymerase I promoter piRNA metabolic process transcription from RNA polymerase III promoter innate immune response positive regulation of viral transcription transcription initiation from RNA polymerase I promoter somatic stem cell population maintenance RNA splicing DNA repair transcription-coupled nucleotide-excision repair transcription elongation from RNA polymerase II promoter viral process nucleotide-excision repair negative regulation of gene expression, epigenetic transcription from RNA polymerase II promoter regulation of gene expression, epigenetic termination of RNA polymerase I transcription positive regulation of type I interferon production termination of RNA polymerase III transcription gene expression 7-methylguanosine mRNA capping transcription elongation from RNA polymerase I promoter Components
cytosol nucleoplasm nucleus DNA-directed RNA polymerase I complex DNA-directed RNA polymerase III complex DNA-directed RNA polymerase II, core complex |
General Function | Dna-directed rna polymerase activity |
Specific Function | DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non-coding RNAs, and small RNAs, such as 5S rRNA and tRNAs, respectively. Pol II is the central component of the basal RNA polymerase II transcription machinery. Pols are composed of mobile elements that move relative to each other. In Pol II, POLR2E/RPB5 is part of the lower jaw surrounding the central large cleft and thought to grab the incoming DNA template. Seems to be the major component in this process (By similarity). |
Transmembrane Regions | |
GenBank Protein ID | 232954 |
UniProtKB ID | P19388 |
UniProtKB Entry Name | RPAB1_HUMAN |
Cellular Location | Nucleus |
Gene sequence | >lcl|BSEQ0012583|DNA-directed RNA polymerases I, II, and III subunit RPABC1 (POLR2E) ATGGACGACGAGGAGGAGACGTACCGGCTCTGGAAAATCCGCAAGACCATCATGCAGCTG TGCCACGACCGTGGCTATCTGGTGACCCAGGACGAGCTTGACCAGACCCTGGAGGAGTTC AAAGCCCAATTTGGGGACAAGCCGAGTGAGGGGCGGCCGCGGCGCACGGACCTCACCGTG CTGGTGGCCCACAACGATGACCCCACCGACCAGATGTTTGTGTTCTTTCCAGAGGAGCCC AAGGTGGGCATCAAGACCATCAAGGTGTACTGCCAGCGCATGCAGGAGGAGAACATCACA CGGGCTCTCATCGTGGTGCAGCAGGGCATGACACCCTCCGCCAAGCAGTCCCTGGTCGAC ATGGCCCCCAAGTACATCCTGGAGCAGTTTCTGCAGCAGGAGCTGCTCATCAACATCACG GAGCACGAGCTAGTCCCTGAGCACGTCGTCATGACCAAGGAGGAGGTGACAGAGCTGCTG GCCCGATATAAGCTCCGAGAGAACCAGCTGCCCAGGATCCAGGCGGGGGACCCTGTGGCG CGCTACTTTGGGATAAAGCGTGGGCAGGTGGTGAAGATCATCCGGCCCAGTGAGACGGCT GGCAGGTACATCACCTACCGGCTGGTGCAGTAG |
GenBank Gene ID | S42643 |
GeneCard ID | None |
GenAtlas ID | |
HGNC ID | HGNC:9192 |
Chromosome Location | 19 |
Locus | 19p13.3 |
References |
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Related FRC
FRCD ID | Name | Exact Mass | Structure |
---|---|---|---|
Amanullin |
886.979 |
||
Amaninamide |
902.978 |
||
Amanin |
903.962 |
||
Proamanullin |
870.98 |
||
Luteoskyrin |
574.494 |
||
Patulin |
154.121 |