DNA-directed RNA polymerases I, II, and III subunit RPABC1


NameDNA-directed RNA polymerases I, II, and III subunit RPABC1
SynonymsDNA-directed RNA polymerase II 23 kDa polypeptide DNA-directed RNA polymerase II subunit E RNA polymerases I, II, and III subunit ABC1 RPB5 homolog XAP4
Gene NamePOLR2E
OrganismHuman
Amino acid sequence
>lcl|BSEQ0012582|DNA-directed RNA polymerases I, II, and III subunit RPABC1
MDDEEETYRLWKIRKTIMQLCHDRGYLVTQDELDQTLEEFKAQSGDKPSEGRPRRTDLTV
LVAHNDDPTDQMFVFFPEEPKVGIKTIKVYCQRMQEENITRALIVVQQGMTPSAKQSLVD
MAPKYILEQFLQQELLINITEHELVPEHVVMTKEEVTELLARYKLRENQLPRIQAGDPVA
RYFGIKRGQVVKIIRPSETAGRYITYRLVQ
Number of residues210
Molecular Weight24551.075
Theoretical pI5.76
GO Classification
Functions
    DNA binding
    DNA-directed RNA polymerase activity
Processes
    transcription initiation from RNA polymerase II promoter
    gene silencing by RNA
    transcription elongation from RNA polymerase III promoter
    mRNA splicing, via spliceosome
    transcription from RNA polymerase I promoter
    piRNA metabolic process
    transcription from RNA polymerase III promoter
    innate immune response
    positive regulation of viral transcription
    transcription initiation from RNA polymerase I promoter
    somatic stem cell population maintenance
    RNA splicing
    DNA repair
    transcription-coupled nucleotide-excision repair
    transcription elongation from RNA polymerase II promoter
    viral process
    nucleotide-excision repair
    negative regulation of gene expression, epigenetic
    transcription from RNA polymerase II promoter
    regulation of gene expression, epigenetic
    termination of RNA polymerase I transcription
    positive regulation of type I interferon production
    termination of RNA polymerase III transcription
    gene expression
    7-methylguanosine mRNA capping
    transcription elongation from RNA polymerase I promoter
Components
    cytosol
    nucleoplasm
    nucleus
    DNA-directed RNA polymerase I complex
    DNA-directed RNA polymerase III complex
    DNA-directed RNA polymerase II, core complex
General FunctionDna-directed rna polymerase activity
Specific FunctionDNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non-coding RNAs, and small RNAs, such as 5S rRNA and tRNAs, respectively. Pol II is the central component of the basal RNA polymerase II transcription machinery. Pols are composed of mobile elements that move relative to each other. In Pol II, POLR2E/RPB5 is part of the lower jaw surrounding the central large cleft and thought to grab the incoming DNA template. Seems to be the major component in this process (By similarity).
Transmembrane Regions
GenBank Protein ID232954
UniProtKB IDP19388
UniProtKB Entry NameRPAB1_HUMAN
Cellular LocationNucleus
Gene sequence
>lcl|BSEQ0012583|DNA-directed RNA polymerases I, II, and III subunit RPABC1 (POLR2E)
ATGGACGACGAGGAGGAGACGTACCGGCTCTGGAAAATCCGCAAGACCATCATGCAGCTG
TGCCACGACCGTGGCTATCTGGTGACCCAGGACGAGCTTGACCAGACCCTGGAGGAGTTC
AAAGCCCAATTTGGGGACAAGCCGAGTGAGGGGCGGCCGCGGCGCACGGACCTCACCGTG
CTGGTGGCCCACAACGATGACCCCACCGACCAGATGTTTGTGTTCTTTCCAGAGGAGCCC
AAGGTGGGCATCAAGACCATCAAGGTGTACTGCCAGCGCATGCAGGAGGAGAACATCACA
CGGGCTCTCATCGTGGTGCAGCAGGGCATGACACCCTCCGCCAAGCAGTCCCTGGTCGAC
ATGGCCCCCAAGTACATCCTGGAGCAGTTTCTGCAGCAGGAGCTGCTCATCAACATCACG
GAGCACGAGCTAGTCCCTGAGCACGTCGTCATGACCAAGGAGGAGGTGACAGAGCTGCTG
GCCCGATATAAGCTCCGAGAGAACCAGCTGCCCAGGATCCAGGCGGGGGACCCTGTGGCG
CGCTACTTTGGGATAAAGCGTGGGCAGGTGGTGAAGATCATCCGGCCCAGTGAGACGGCT
GGCAGGTACATCACCTACCGGCTGGTGCAGTAG
GenBank Gene IDS42643
GeneCard IDNone
GenAtlas ID
HGNC IDHGNC:9192
Chromosome Location19
Locus19p13.3
References
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