Cytochrome c oxidase subunit 5A, mitochondrial


NameCytochrome c oxidase subunit 5A, mitochondrial
SynonymsCytochrome c oxidase polypeptide Va
Gene NameCOX5A
OrganismHuman
Amino acid sequence
>lcl|BSEQ0012775|Cytochrome c oxidase subunit 5A, mitochondrial
MLGAALRRCAVAATTRADPRGLLHSARTPGPAVAIQSVRCYSHGSQETDEEFDARWVTYF
NKPDIDAWELRKGINTLVTYDMVPEPKIIDAALRACRRLNDFASTVRILEVVKDKAGPHK
EIYPYVIQELRPTLNELGISTPEELGLDKV
Number of residues150
Molecular Weight16761.985
Theoretical pI6.78
GO Classification
Functions
    cytochrome-c oxidase activity
    metal ion binding
    electron carrier activity
Processes
    cellular metabolic process
    respiratory electron transport chain
    hydrogen ion transmembrane transport
    mitochondrial electron transport, cytochrome c to oxygen
    gene expression
    small molecule metabolic process
    transcription initiation from RNA polymerase II promoter
Components
    myelin sheath
    mitochondrial inner membrane
    mitochondrial respiratory chain complex IV
    extracellular exosome
General FunctionMetal ion binding
Specific FunctionThis is the heme A-containing chain of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport.
Transmembrane Regions
GenBank Protein ID695360
UniProtKB IDP20674
UniProtKB Entry NameCOX5A_HUMAN
Cellular LocationMitochondrion inner membrane
Gene sequence
>lcl|BSEQ0012776|Cytochrome c oxidase subunit 5A, mitochondrial (COX5A)
ATGCTGGGCGCCGCTCTCCGCCGCTGCGCTGTGGCCGCAACCACCCGGGCCGACCCTCGA
GGCCTCCTGCACTCCGCCCGGACCCCCGGCCCCGCCGTGGCTATCCAGTCAGTTCGCTGC
TATTCCCATGGGTCACAGGAGACAGATGAGGAGTTTGATGCTCGCTGGGTAACATACTTC
AACAAGCCAGATATAGATGCCTGGGAATTGCGTAAAGGGATAAACACACTTGTTACCTAT
GATATGGTTCCAGAGCCCAAAATCATTGATGCTGCTTTGCGGGCATGCAGACGGTTAAAT
GATTTTGCTAGTACAGTTCGTATCCTAGAGGTTGTTAAGGACAAAGCAGGACCTCATAAG
GAAATCTACCCCTATGTCATCCAGGAACTTAGACCAACTTTAAATGAACTGGGAATCTCC
ACTCCGGAGGAACTGGGCCTTGACAAAGTGTAA
GenBank Gene IDM22760
GeneCard IDNone
GenAtlas ID
HGNC IDHGNC:2267
Chromosome Location15
Locus15q24.1
References
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  2. Uddin M, Opazo JC, Wildman DE, Sherwood CC, Hof PR, Goodman M, Grossman LI: Molecular evolution of the cytochrome c oxidase subunit 5A gene in primates. BMC Evol Biol. 2008 Jan 15;8:8. doi: 10.1186/1471-2148-8-8.[18197981 ]
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  4. Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. 2004 Oct;14(10B):2121-7.[15489334 ]
  5. Hughes GJ, Frutiger S, Paquet N, Pasquali C, Sanchez JC, Tissot JD, Bairoch A, Appel RD, Hochstrasser DF: Human liver protein map: update 1993. Electrophoresis. 1993 Nov;14(11):1216-22.[8313870 ]
  6. Kovalyov LI, Shishkin SS, Efimochkin AS, Kovalyova MA, Ershova ES, Egorov TA, Musalyamov AK: The major protein expression profile and two-dimensional protein database of human heart. Electrophoresis. 1995 Jul;16(7):1160-9.[7498159 ]
  7. Burkard TR, Planyavsky M, Kaupe I, Breitwieser FP, Burckstummer T, Bennett KL, Superti-Furga G, Colinge J: Initial characterization of the human central proteome. BMC Syst Biol. 2011 Jan 26;5:17. doi: 10.1186/1752-0509-5-17.[21269460 ]
  8. Vaca Jacome AS, Rabilloud T, Schaeffer-Reiss C, Rompais M, Ayoub D, Lane L, Bairoch A, Van Dorsselaer A, Carapito C: N-terminome analysis of the human mitochondrial proteome. Proteomics. 2015 Jul;15(14):2519-24. doi: 10.1002/pmic.201400617. Epub 2015 Jun 8.[25944712 ]
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Related FRC


FRCD ID Name Exact Mass Structure



Phosphine




33.998



Zinc phosphide




264.136



Methanol




32.042



Linamarin




247.247



Acetonitrile




41.053



Acrylonitrile




53.064



Beta-Aminopropionitrile




70.095



Benzonitrile




103.124



Benzeneacetonitrile




117.151



Chlorfenapyr




407.615



Chlorothalonil




265.902



2,6-Dichlorobenzonitrile




172.008



Thallium




239.83



Cyanide




26.018



Mandelonitrile




133.15



Bromoxynil




276.915