Cannabinoid receptor 1
Name | Cannabinoid receptor 1 |
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Synonyms | CANN6 CB-R CNR |
Gene Name | CNR1 |
Organism | Human |
Amino acid sequence | >lcl|BSEQ0000122|Cannabinoid receptor 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQE KMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIA VLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVF HRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLM WTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWK AHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLL AIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQ PLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL |
Number of residues | 472 |
Molecular Weight | 52857.365 |
Theoretical pI | 8.25 |
GO Classification |
Functions
drug binding cannabinoid receptor activity Processes
adenylate cyclase-modulating G-protein coupled receptor signaling pathway glucose homeostasis regulation of penile erection response to lipopolysaccharide response to nicotine positive regulation of apoptotic process regulation of synaptic transmission, GABAergic sensory perception of pain positive regulation of blood pressure regulation of synaptic transmission, glutamatergic negative regulation of blood pressure response to morphine response to cocaine axonal fasciculation regulation of insulin secretion spermatogenesis negative regulation of dopamine secretion memory negative regulation of fatty acid beta-oxidation G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger response to nutrient positive regulation of acute inflammatory response to antigenic stimulus cannabinoid signaling pathway response to ethanol positive regulation of fever generation negative regulation of action potential aging positive regulation of neuron projection development negative regulation of mast cell activation maternal process involved in female pregnancy regulation of feeding behavior negative regulation of nitric-oxide synthase activity Components
integral component of plasma membrane axon intracellular membrane-bounded organelle growth cone membrane raft plasma membrane |
General Function | Drug binding |
Specific Function | Involved in cannabinoid-induced CNS effects. Acts by inhibiting adenylate cyclase. Could be a receptor for anandamide. Inhibits L-type Ca(2+) channel current. Isoform 2 and isoform 3 have altered ligand binding. |
Transmembrane Regions | 117-142 155-175 188-212 233-255 274-299 345-365 378-399 |
GenBank Protein ID | 29915 |
UniProtKB ID | P21554 |
UniProtKB Entry Name | CNR1_HUMAN |
Cellular Location | Cell membrane |
Gene sequence | >lcl|BSEQ0010146|Cannabinoid receptor 1 (CNR1) ATGAAGTCGATCCTAGATGGCCTTGCAGATACCACCTTCCGCACCATCACCACTGACCTC CTGTACGTGGGCTCAAATGACATTCAGTACGAAGACATCAAAGGTGACATGGCATCCAAA TTAGGGTACTTCCCACAGAAATTCCCTTTAACTTCCTTTAGGGGAAGTCCCTTCCAAGAG AAGATGACTGCGGGAGACAACCCCCAGCTAGTCCCAGCAGACCAGGTGAACATTACAGAA TTTTACAACAAGTCTCTCTCGTCCTTCAAGGAGAATGAGGAGAACATCCAGTGTGGGGAG AACTTCATGGACATAGAGTGTTTCATGGTCCTGAACCCCAGCCAGCAGCTGGCCATTGCA GTCCTGTCCCTCACGCTGGGCACCTTCACGGTCCTGGAGAACCTCCTGGTGCTGTGCGTC ATCCTCCACTCCCGCAGCCTCCGCTGCAGGCCTTCCTACCACTTCATCGGCAGCCTGGCG GTGGCAGACCTCCTGGGGAGTGTCATTTTTGTCTACAGCTTCATTGACTTCCACGTGTTC CACCGCAAAGATAGCCGCAACGTGTTTCTGTTCAAACTGGGTGGGGTCACGGCCTCCTTC ACTGCCTCCGTGGGCAGCCTGTTCCTCACAGCCATCGACAGGTACATATCCATTCACAGG CCCCTGGCCTATAAGAGGATTGTCACCAGGCCCAAGGCCGTGGTGGCGTTTTGCCTGATG TGGACCATAGCCATTGTGATCGCCGTGCTGCCTCTCCTGGGCTGGAACTGCGAGAAACTG CAATCTGTTTGCTCAGACATTTTCCCACACATTGATGAAACCTACCTGATGTTCTGGATC GGGGTCACCAGCGTACTGCTTCTGTTCATCGTGTATGCGTACATGTATATTCTCTGGAAG GCTCACAGCCACGCCGTCCGCATGATTCAGCGTGGCACCCAGAAGAGCATCATCATCCAC ACGTCTGAGGATGGGAAGGTACAGGTGACCCGGCCAGACCAAGCCCGCATGGACATTAGG TTAGCCAAGACCCTGGTCCTGATCCTGGTGGTGTTGATCATCTGCTGGGGCCCTCTGCTT GCAATCATGGTGTATGATGTCTTTGGGAAGATGAACAAGCTCATTAAGACGGTGTTTGCA TTCTGCAGTATGCTCTGCCTGCTGAACTCCACCGTGAACCCCATCATCTATGCTCTGAGG AGTAAGGACCTGCGACACGCTTTCCGGAGCATGTTTCCCTCTTGTGAAGGCACTGCGCAG CCTCTGGATAACAGCATGGGGGACTCGGACTGCCTGCACAAACACGCAAACAATGCAGCC AGTGTTCACAGGGCCGCAGAAAGCTGCATCAAGAGCACGGTCAAGATTGCCAAGGTAACC ATGTCTGTGTCCACAGACACGTCTGCCGAGGCTCTGTGA |
GenBank Gene ID | X54937 |
GeneCard ID | None |
GenAtlas ID | CNR1 |
HGNC ID | HGNC:2159 |
Chromosome Location | 6 |
Locus | 6q14-q15 |
References |
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Related FRC
FRCD ID | Name | Exact Mass | Structure |
---|---|---|---|
Capsaicin |
305.418 |
||
Chlorpyrifos |
350.575 |