D(1A) dopamine receptor
Name | D(1A) dopamine receptor |
---|---|
Synonyms | Dopamine D1 receptor |
Gene Name | DRD1 |
Organism | Human |
Amino acid sequence | >lcl|BSEQ0021252|D(1A) dopamine receptor MRTLNTSAMDGTGLVVERDFSVRILTACFLSLLILSTLLGNTLVCAAVIRFRHLRSKVTN FFVISLAVSDLLVAVLVMPWKAVAEIAGFWPFGSFCNIWVAFDIMCSTASILNLCVISVD RYWAISSPFRYERKMTPKAAFILISVAWTLSVLISFIPVQLSWHKAKPTSPSDGNATSLA ETIDNCDSSLSRTYAISSSVISFYIPVAIMIVTYTRIYRIAQKQIRRIAALERAAVHAKN CQTTTGNGKPVECSQPESSFKMSFKRETKVLKTLSVIMGVFVCCWLPFFILNCILPFCGS GETQPFCIDSNTFDVFVWFGWANSSLNPIIYAFNADFRKAFSTLLGCYRLCPATNNAIET VSINNNGAAMFSSHHEPRGSISKECNLVYLIPHAVGSSEDLKKEEAAGIARPLEKLSPAL SVILDYDTDVSLEKIQPITQNGQHPT |
Number of residues | 446 |
Molecular Weight | 49292.765 |
Theoretical pI | 8.34 |
GO Classification |
Functions
drug binding dopamine binding dopamine neurotransmitter receptor activity dopamine neurotransmitter receptor activity, coupled via Gs G-protein coupled amine receptor activity Processes
synapse assembly response to retinoic acid learning positive regulation of membrane potential dopamine metabolic process response to amino acid positive regulation of long-term synaptic potentiation response to food behavioral fear response long term synaptic depression positive regulation of feeding behavior grooming behavior negative regulation of cell migration regulation of dopamine metabolic process phospholipase C-activating dopamine receptor signaling pathway peristalsis response to amphetamine response to ethanol long-term synaptic potentiation positive regulation of cell migration sensitization operant conditioning striatum development response to nicotine negative regulation of circadian sleep/wake cycle, sleep mating behavior response to estradiol synaptic transmission, dopaminergic regulation of long-term neuronal synaptic plasticity response to activity positive regulation of potassium ion transport response to drug regulation of dopamine uptake involved in synaptic transmission prepulse inhibition activation of adenylate cyclase activity maternal behavior astrocyte development G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger temperature homeostasis response to antidepressant orbitofrontal cortex development social behavior protein import into nucleus positive regulation of adenylate cyclase activity involved in G-protein coupled receptor signaling pathway adult walking behavior positive regulation of synaptic transmission, glutamatergic sensory perception of chemical stimulus neuronal action potential glucose import visual learning transmission of nerve impulse adenylate cyclase-activating dopamine receptor signaling pathway conditioned taste aversion positive regulation of release of sequestered calcium ion into cytosol cellular response to insulin stimulus cerebral cortex GABAergic interneuron migration response to morphine regulation of vasoconstriction adenylate cyclase-activating G-protein coupled receptor signaling pathway vasodilation calcium-mediated signaling cellular response to hypoxia dopamine transport dentate gyrus development behavioral response to cocaine negative regulation of protein kinase activity cellular response to catecholamine stimulus positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway memory positive regulation of cAMP biosynthetic process habituation Components
cytosol dendritic spine head ciliary membrane integral component of plasma membrane dendritic spine neck nonmotile primary cilium nucleus plasma membrane axon terminus endoplasmic reticulum membrane caveola neuronal cell body dendritic shaft |
General Function | G-protein coupled amine receptor activity |
Specific Function | Dopamine receptor whose activity is mediated by G proteins which activate adenylyl cyclase. |
Transmembrane Regions | 24-49 61-87 97-119 139-163 193-218 273-299 313-337 |
GenBank Protein ID | 30397 |
UniProtKB ID | P21728 |
UniProtKB Entry Name | DRD1_HUMAN |
Cellular Location | Cell membrane |
Gene sequence | >lcl|BSEQ0021253|D(1A) dopamine receptor (DRD1) ATGAGGACTCTGAACACCTCTGCCATGGACGGGACTGGGCTGGTGGTGGAGAGGGACTTC TCTGTTCGTATCCTCACTGCCTGTTTCCTGTCGCTGCTCATCCTGTCCACGCTCCTGGGG AACACGCTGGTCTGTGCTGCCGTTATCAGGTTCCGACACCTGCGGTCCAAGGTGACCAAC TTCTTTGTCATCTCCTTGGCTGTGTCAGATCTCTTGGTGGCCGTCCTGGTCATGCCCTGG AAGGCAGTGGCTGAGATTGCTGGCTTCTGGCCCTTTGGGTCCTTCTGTAACATCTGGGTG GCCTTTGACATCATGTGCTCCACTGCATCCATCCTCAACCTCTGTGTGATCAGCGTGGAC AGGTATTGGGCTATCTCCAGCCCTTTCCGGTATGAGAGAAAGATGACCCCCAAGGCAGCC TTCATCCTGATCAGTGTGGCATGGACCTTGTCTGTACTCATCTCCTTCATCCCAGTGCAG CTCAGCTGGCACAAGGCAAAACCCACAAGCCCCTCTGATGGAAATGCCACTTCCCTGGCT GAGACCATAGACAACTGTGACTCCAGCCTCAGCAGGACATATGCCATCTCATCCTCTGTA ATAAGCTTTTACATCCCTGTGGCCATCATGATTGTCACCTACACCAGGATCTACAGGATT GCTCAGAAACAAATACGGCGCATTGCGGCCTTGGAGAGGGCAGCAGTCCACGCCAAGAAT TGCCAGACCACCACAGGTAATGGAAAGCCTGTCGAATGTTCTCAACCGGAAAGTTCTTTT AAGATGTCCTTCAAAAGAGAAACTAAAGTCCTGAAGACTCTGTCGGTGATCATGGGTGTG TTTGTGTGCTGTTGGCTACCTTTCTTCATCTTGAACTGCATTTTGCCCTTCTGTGGGTCT GGGGAGACGCAGCCCTTCTGCATTGATTCCAACACCTTTGACGTGTTTGTGTGGTTTGGG TGGGCTAATTCATCCTTGAACCCCATCATTTATGCCTTTAATGCTGATTTTCGGAAGGCA TTTTCAACCCTCTTAGGATGCTACAGACTTTGCCCTGCGACGAATAATGCCATAGAGACG GTGAGTATCAATAACAATGGGGCCGCGATGTTTTCCAGCCATCATGAGCCACGAGGCTCC ATCTCCAAGGAGTGCAATCTGGTTTACCTGATCCCACATGCTGTGGGCTCCTCTGAGGAC CTGAAAAAGGAGGAGGCAGCTGGCATCGCCAGACCCTTGGAGAAGCTGTCCCCAGCCCTA TCAGTCATATTGGACTATGACACTGACGTCTCTCTGGAGAAGATCCAACCCATCACACAA AACGGTCAGCACCCAACCTGA |
GenBank Gene ID | X55760 |
GeneCard ID | None |
GenAtlas ID | DRD1 |
HGNC ID | HGNC:3020 |
Chromosome Location | 5 |
Locus | 5q35.1 |
References |
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