D(1A) dopamine receptor


NameD(1A) dopamine receptor
SynonymsDopamine D1 receptor
Gene NameDRD1
OrganismHuman
Amino acid sequence
>lcl|BSEQ0021252|D(1A) dopamine receptor
MRTLNTSAMDGTGLVVERDFSVRILTACFLSLLILSTLLGNTLVCAAVIRFRHLRSKVTN
FFVISLAVSDLLVAVLVMPWKAVAEIAGFWPFGSFCNIWVAFDIMCSTASILNLCVISVD
RYWAISSPFRYERKMTPKAAFILISVAWTLSVLISFIPVQLSWHKAKPTSPSDGNATSLA
ETIDNCDSSLSRTYAISSSVISFYIPVAIMIVTYTRIYRIAQKQIRRIAALERAAVHAKN
CQTTTGNGKPVECSQPESSFKMSFKRETKVLKTLSVIMGVFVCCWLPFFILNCILPFCGS
GETQPFCIDSNTFDVFVWFGWANSSLNPIIYAFNADFRKAFSTLLGCYRLCPATNNAIET
VSINNNGAAMFSSHHEPRGSISKECNLVYLIPHAVGSSEDLKKEEAAGIARPLEKLSPAL
SVILDYDTDVSLEKIQPITQNGQHPT
Number of residues446
Molecular Weight49292.765
Theoretical pI8.34
GO Classification
Functions
    drug binding
    dopamine binding
    dopamine neurotransmitter receptor activity
    dopamine neurotransmitter receptor activity, coupled via Gs
    G-protein coupled amine receptor activity
Processes
    synapse assembly
    response to retinoic acid
    learning
    positive regulation of membrane potential
    dopamine metabolic process
    response to amino acid
    positive regulation of long-term synaptic potentiation
    response to food
    behavioral fear response
    long term synaptic depression
    positive regulation of feeding behavior
    grooming behavior
    negative regulation of cell migration
    regulation of dopamine metabolic process
    phospholipase C-activating dopamine receptor signaling pathway
    peristalsis
    response to amphetamine
    response to ethanol
    long-term synaptic potentiation
    positive regulation of cell migration
    sensitization
    operant conditioning
    striatum development
    response to nicotine
    negative regulation of circadian sleep/wake cycle, sleep
    mating behavior
    response to estradiol
    synaptic transmission, dopaminergic
    regulation of long-term neuronal synaptic plasticity
    response to activity
    positive regulation of potassium ion transport
    response to drug
    regulation of dopamine uptake involved in synaptic transmission
    prepulse inhibition
    activation of adenylate cyclase activity
    maternal behavior
    astrocyte development
    G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
    temperature homeostasis
    response to antidepressant
    orbitofrontal cortex development
    social behavior
    protein import into nucleus
    positive regulation of adenylate cyclase activity involved in G-protein coupled receptor signaling pathway
    adult walking behavior
    positive regulation of synaptic transmission, glutamatergic
    sensory perception of chemical stimulus
    neuronal action potential
    glucose import
    visual learning
    transmission of nerve impulse
    adenylate cyclase-activating dopamine receptor signaling pathway
    conditioned taste aversion
    positive regulation of release of sequestered calcium ion into cytosol
    cellular response to insulin stimulus
    cerebral cortex GABAergic interneuron migration
    response to morphine
    regulation of vasoconstriction
    adenylate cyclase-activating G-protein coupled receptor signaling pathway
    vasodilation
    calcium-mediated signaling
    cellular response to hypoxia
    dopamine transport
    dentate gyrus development
    behavioral response to cocaine
    negative regulation of protein kinase activity
    cellular response to catecholamine stimulus
    positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway
    memory
    positive regulation of cAMP biosynthetic process
    habituation
Components
    cytosol
    dendritic spine head
    ciliary membrane
    integral component of plasma membrane
    dendritic spine neck
    nonmotile primary cilium
    nucleus
    plasma membrane
    axon terminus
    endoplasmic reticulum membrane
    caveola
    neuronal cell body
    dendritic shaft
General FunctionG-protein coupled amine receptor activity
Specific FunctionDopamine receptor whose activity is mediated by G proteins which activate adenylyl cyclase.
Transmembrane Regions24-49 61-87 97-119 139-163 193-218 273-299 313-337
GenBank Protein ID30397
UniProtKB IDP21728
UniProtKB Entry NameDRD1_HUMAN
Cellular LocationCell membrane
Gene sequence
>lcl|BSEQ0021253|D(1A) dopamine receptor (DRD1)
ATGAGGACTCTGAACACCTCTGCCATGGACGGGACTGGGCTGGTGGTGGAGAGGGACTTC
TCTGTTCGTATCCTCACTGCCTGTTTCCTGTCGCTGCTCATCCTGTCCACGCTCCTGGGG
AACACGCTGGTCTGTGCTGCCGTTATCAGGTTCCGACACCTGCGGTCCAAGGTGACCAAC
TTCTTTGTCATCTCCTTGGCTGTGTCAGATCTCTTGGTGGCCGTCCTGGTCATGCCCTGG
AAGGCAGTGGCTGAGATTGCTGGCTTCTGGCCCTTTGGGTCCTTCTGTAACATCTGGGTG
GCCTTTGACATCATGTGCTCCACTGCATCCATCCTCAACCTCTGTGTGATCAGCGTGGAC
AGGTATTGGGCTATCTCCAGCCCTTTCCGGTATGAGAGAAAGATGACCCCCAAGGCAGCC
TTCATCCTGATCAGTGTGGCATGGACCTTGTCTGTACTCATCTCCTTCATCCCAGTGCAG
CTCAGCTGGCACAAGGCAAAACCCACAAGCCCCTCTGATGGAAATGCCACTTCCCTGGCT
GAGACCATAGACAACTGTGACTCCAGCCTCAGCAGGACATATGCCATCTCATCCTCTGTA
ATAAGCTTTTACATCCCTGTGGCCATCATGATTGTCACCTACACCAGGATCTACAGGATT
GCTCAGAAACAAATACGGCGCATTGCGGCCTTGGAGAGGGCAGCAGTCCACGCCAAGAAT
TGCCAGACCACCACAGGTAATGGAAAGCCTGTCGAATGTTCTCAACCGGAAAGTTCTTTT
AAGATGTCCTTCAAAAGAGAAACTAAAGTCCTGAAGACTCTGTCGGTGATCATGGGTGTG
TTTGTGTGCTGTTGGCTACCTTTCTTCATCTTGAACTGCATTTTGCCCTTCTGTGGGTCT
GGGGAGACGCAGCCCTTCTGCATTGATTCCAACACCTTTGACGTGTTTGTGTGGTTTGGG
TGGGCTAATTCATCCTTGAACCCCATCATTTATGCCTTTAATGCTGATTTTCGGAAGGCA
TTTTCAACCCTCTTAGGATGCTACAGACTTTGCCCTGCGACGAATAATGCCATAGAGACG
GTGAGTATCAATAACAATGGGGCCGCGATGTTTTCCAGCCATCATGAGCCACGAGGCTCC
ATCTCCAAGGAGTGCAATCTGGTTTACCTGATCCCACATGCTGTGGGCTCCTCTGAGGAC
CTGAAAAAGGAGGAGGCAGCTGGCATCGCCAGACCCTTGGAGAAGCTGTCCCCAGCCCTA
TCAGTCATATTGGACTATGACACTGACGTCTCTCTGGAGAAGATCCAACCCATCACACAA
AACGGTCAGCACCCAACCTGA
GenBank Gene IDX55760
GeneCard IDNone
GenAtlas IDDRD1
HGNC IDHGNC:3020
Chromosome Location5
Locus5q35.1
References
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  2. Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. 2004 Oct;14(10B):2121-7.[15489334 ]
  3. Dearry A, Gingrich JA, Falardeau P, Fremeau RT Jr, Bates MD, Caron MG: Molecular cloning and expression of the gene for a human D1 dopamine receptor. Nature. 1990 Sep 6;347(6288):72-6.[2144334 ]
  4. Zhou QY, Grandy DK, Thambi L, Kushner JA, Van Tol HH, Cone R, Pribnow D, Salon J, Bunzow JR, Civelli O: Cloning and expression of human and rat D1 dopamine receptors. Nature. 1990 Sep 6;347(6288):76-80.[2168520 ]
  5. Sunahara RK, Niznik HB, Weiner DM, Stormann TM, Brann MR, Kennedy JL, Gelernter JE, Rozmahel R, Yang YL, Israel Y, et al.: Human dopamine D1 receptor encoded by an intronless gene on chromosome 5. Nature. 1990 Sep 6;347(6288):80-3.[1975640 ]
  6. Ohara K, Ulpian C, Seeman P, Sunahara RK, Van Tol HH, Niznik HB: Schizophrenia: dopamine D1 receptor sequence is normal, but has DNA polymorphisms. Neuropsychopharmacology. 1993 Feb;8(2):131-5.[8471124 ]
  7. Jin H, Xie Z, George SR, O'Dowd BF: Palmitoylation occurs at cysteine 347 and cysteine 351 of the dopamine D(1) receptor. Eur J Pharmacol. 1999 Dec 15;386(2-3):305-12.[10618483 ]
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Related FRC


FRCD ID Name Exact Mass Structure



Dopamine




153.181



Tyramine




137.182



Mercuric chloride




271.492



Hydroxytriphenylstannane




367.035



Quetiapine




383.51



Aripiprazole




448.388



Olanzapine




312.435



Cyproheptadine




287.406



Imipramine




280.415



Risperidone




410.493



L-Dopa




197.19



Norepinephrine




169.18



Agroclavine




238.334



Elymoclavine




254.333



Nantenine




339.391



Thiram




240.416