Thromboxane A2 receptor
Name | Thromboxane A2 receptor |
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Synonyms | Prostanoid TP receptor TXA2-R |
Gene Name | TBXA2R |
Organism | Human |
Amino acid sequence | >lcl|BSEQ0037068|Thromboxane A2 receptor MWPNGSSLGPCFRPTNITLEERRLIASPWFAASFCVVGLASNLLALSVLAGARQGGSHTR SSFLTFLCGLVLTDFLGLLVTGTIVVSQHAALFEWHAVDPGCRLCRFMGVVMIFFGLSPL LLGAAMASERYLGITRPFSRPAVASQRRAWATVGLVWAAALALGLLPLLGVGRYTVQYPG SWCFLTLGAESGDVAFGLLFSMLGGLSVGLSFLLNTVSVATLCHVYHGQEAAQQRPRDSE VEMMAQLLGIMVVASVCWLPLLVFIAQTVLRNPPAMSPAGQLSRTTEKELLIYLRVATWN QILDPWVYILFRRAVLRRLQPRLSTRPRSLSLQPQLTQRSGLQ |
Number of residues | 343 |
Molecular Weight | 37430.69 |
Theoretical pI | 10.31 |
GO Classification |
Functions
thromboxane A2 receptor activity guanyl-nucleotide exchange factor activity Processes
G-protein coupled receptor signaling pathway positive regulation of smooth muscle contraction thromboxane A2 signaling pathway response to lipopolysaccharide blood coagulation response to drug positive regulation of GTPase activity positive regulation of vasoconstriction inflammatory response positive regulation of angiogenesis platelet activation response to nutrient positive regulation of blood pressure positive regulation of cytosolic calcium ion concentration second-messenger-mediated signaling Components
plasma membrane cytosol acrosomal vesicle integral component of plasma membrane |
General Function | Thromboxane a2 receptor activity |
Specific Function | Receptor for thromboxane A2 (TXA2), a potent stimulator of platelet aggregation. The activity of this receptor is mediated by a G-protein that activates a phosphatidylinositol-calcium second messenger system. In the kidney, the binding of TXA2 to glomerular TP receptors causes intense vasoconstriction. Activates phospholipase C. Isoform 1 activates adenylyl cyclase. Isoform 2 inhibits adenylyl cyclase. |
Transmembrane Regions | 30-52 67-87 107-128 150-172 194-219 247-270 290-311 |
GenBank Protein ID | 533326 |
UniProtKB ID | P21731 |
UniProtKB Entry Name | TA2R_HUMAN |
Cellular Location | Cell membrane |
Gene sequence | >lcl|BSEQ0019006|Thromboxane A2 receptor (TBXA2R) ATGTGGCCCAACGGCAGTTCCCTGGGGCCCTGTTTCCGGCCCACAAACATTACCCTGGAG GAGAGACGGCTGATCGCCTCGCCCTGGTTCGCCGCCTCCTTCTGCGTGGTGGGCCTGGCC TCCAACCTGCTGGCCCTGAGCGTGCTGGCGGGCGCGCGGCAGGGGGGTTCGCACACGCGC TCCTCCTTCCTCACCTTCCTCTGCGGCCTCGTCCTCACCGACTTCCTGGGGCTGCTGGTG ACCGGTACCATCGTGGTGTCCCAGCACGCCGCGCTCTTCGAGTGGCACGCCGTGGACCCT GGCTGCCGTCTCTGTCGCTTCATGGGCGTCGTCATGATCTTCTTCGGCCTGTCCCCGCTG CTGCTGGGGGCCGCCATGGCCTCAGAGCGCTACCTGGGTATCACCCGGCCCTTCTCGCGC CCGGCGGTCGCCTCGCAGCGCCGCGCCTGGGCCACCGTGGGGCTGGTGTGGGCGGCCGCG CTGGCGCTGGGCCTGCTGCCCCTGCTGGGCGTGGGTCGCTACACCGTGCAATACCCGGGG TCCTGGTGCTTCCTGACGCTGGGCGCCGAGTCCGGGGACGTGGCCTTCGGGCTGCTCTTC TCCATGCTGGGCGGCCTCTCGGTCGGGCTGTCCTTCCTGCTGAACACGGTCAGCGTGGCC ACCCTGTGCCACGTCTACCACGGGCAGGAGGCGGCCCAGCAGCGTCCCCGGGACTCCGAG GTGGAGATGATGGCTCAGCTCCTGGGGATCATGGTGGTGGCCAGCGTGTGTTGGCTGCCC CTTCTGGTCTTCATCGCCCAGACAGTGCTGCGAAACCCGCCTGCCATGAGCCCCGCCGGG CAGCTGTCCCGCACCACGGAGAAGGAGCTGCTCATCTACTTGCGCGTGGCCACCTGGAAC CAGATCCTGGACCCCTGGGTGTATATCCTGTTCCGCCGCGCCGTGCTCCGGCGTCTCCAG CCTCGCCTCAGCACCCGGCCCAGGTCGCTGTCCCTCCAGCCCCAGCTCACGCAGCGCTCC GGGCTGCAGTAG |
GenBank Gene ID | D38081 |
GeneCard ID | None |
GenAtlas ID | TBXA2R |
HGNC ID | HGNC:11608 |
Chromosome Location | 19 |
Locus | 19p13.3 |
References |
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Related FRC
FRCD ID | Name | Exact Mass | Structure |
---|---|---|---|
Isoxaben |
332.4 |
||
Hexylresorcinol |
194.274 |