Fibroblast growth factor receptor 2


NameFibroblast growth factor receptor 2
Synonyms2.7.10.1 BEK FGFR-2 K-sam Keratinocyte growth factor receptor KGFR KSAM
Gene NameFGFR2
OrganismHuman
Amino acid sequence
>lcl|BSEQ0001492|Fibroblast growth factor receptor 2
MVSWGRFICLVVVTMATLSLARPSFSLVEDTTLEPEEPPTKYQISQPEVYVAAPGESLEV
RCLLKDAAVISWTKDGVHLGPNNRTVLIGEYLQIKGATPRDSGLYACTASRTVDSETWYF
MVNVTDAISSGDDEDDTDGAEDFVSENSNNKRAPYWTNTEKMEKRLHAVPAANTVKFRCP
AGGNPMPTMRWLKNGKEFKQEHRIGGYKVRNQHWSLIMESVVPSDKGNYTCVVENEYGSI
NHTYHLDVVERSPHRPILQAGLPANASTVVGGDVEFVCKVYSDAQPHIQWIKHVEKNGSK
YGPDGLPYLKVLKAAGVNTTDKEIEVLYIRNVTFEDAGEYTCLAGNSIGISFHSAWLTVL
PAPGREKEITASPDYLEIAIYCIGVFLIACMVVTVILCRMKNTTKKPDFSSQPAVHKLTK
RIPLRRQVTVSAESSSSMNSNTPLVRITTRLSSTADTPMLAGVSEYELPEDPKWEFPRDK
LTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKDLSDLVSEMEMMKM
IGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLRARRPPGMEYSYDINRVPEEQMTF
KDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDINNIDYYKKT
TNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELFKLLKEGH
RMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRILTLTTNEEYLDLSQPLEQYS
PSYPDTRSSCSSGDDSVFSPDPMPYEPCLPQYPHINGSVKT
Number of residues821
Molecular Weight92024.29
Theoretical pI5.68
GO Classification
Functions
    ATP binding
    fibroblast growth factor-activated receptor activity
    protein tyrosine kinase activity
    heparin binding
    protein homodimerization activity
    fibroblast growth factor binding
Processes
    positive regulation of MAPK cascade
    fibroblast growth factor receptor signaling pathway involved in negative regulation of apoptotic process in bone marrow
    vascular endothelial growth factor receptor signaling pathway
    prostate epithelial cord elongation
    mammary gland bud formation
    positive regulation of epithelial cell proliferation
    synaptic vesicle transport
    embryonic cranial skeleton morphogenesis
    post-embryonic development
    orbitofrontal cortex development
    embryonic organ morphogenesis
    fibroblast growth factor receptor signaling pathway involved in orbitofrontal cortex development
    positive regulation of cell proliferation
    prostate gland morphogenesis
    bone morphogenesis
    membranous septum morphogenesis
    phosphatidylinositol-mediated signaling
    ureteric bud development
    embryonic digestive tract morphogenesis
    fibroblast growth factor receptor signaling pathway involved in positive regulation of cell proliferation in bone marrow
    negative regulation of transcription from RNA polymerase II promoter
    otic vesicle formation
    regulation of cell fate commitment
    branch elongation involved in salivary gland morphogenesis
    axon guidance
    mesenchymal cell differentiation
    positive regulation of ERK1 and ERK2 cascade
    ventricular zone neuroblast division
    embryonic organ development
    activation of MAPKK activity
    inner ear morphogenesis
    gland morphogenesis
    angiogenesis
    outflow tract septum morphogenesis
    regulation of fibroblast growth factor receptor signaling pathway
    branching involved in labyrinthine layer morphogenesis
    epidermal growth factor receptor signaling pathway
    mesenchymal cell differentiation involved in lung development
    positive regulation of smooth muscle cell proliferation
    apoptotic process
    embryonic pattern specification
    regulation of branching involved in prostate gland morphogenesis
    small GTPase mediated signal transduction
    hair follicle morphogenesis
    axonogenesis
    positive regulation of cardiac muscle cell proliferation
    regulation of morphogenesis of a branching structure
    branching involved in prostate gland morphogenesis
    innate immune response
    mesenchymal cell proliferation involved in lung development
    protein autophosphorylation
    fibroblast growth factor receptor signaling pathway
    endodermal digestive tract morphogenesis
    ventricular cardiac muscle tissue morphogenesis
    cell-cell signaling
    lacrimal gland development
    neuromuscular junction development
    positive regulation of cell cycle
    regulation of osteoblast differentiation
    branching involved in salivary gland morphogenesis
    peptidyl-tyrosine phosphorylation
    mesodermal cell differentiation
    skeletal system morphogenesis
    insulin receptor signaling pathway
    epidermis morphogenesis
    regulation of ERK1 and ERK2 cascade
    lateral sprouting from an epithelium
    regulation of multicellular organism growth
    positive regulation of epithelial cell proliferation involved in lung morphogenesis
    regulation of osteoblast proliferation
    branching morphogenesis of a nerve
    midbrain development
    bone mineralization
    epithelial cell proliferation involved in salivary gland morphogenesis
    MAPK cascade
    lung alveolus development
    lens fiber cell development
    positive regulation of mesenchymal cell proliferation
    regulation of smooth muscle cell differentiation
    bud elongation involved in lung branching
    Fc-epsilon receptor signaling pathway
    morphogenesis of embryonic epithelium
    organ morphogenesis
    epithelial to mesenchymal transition
    neurotrophin TRK receptor signaling pathway
    organ growth
    limb bud formation
    pyramidal neuron development
    positive regulation of phospholipase activity
    regulation of smoothened signaling pathway
    cell fate commitment
    positive regulation of canonical Wnt signaling pathway
    negative regulation of epithelial cell proliferation
    fibroblast growth factor receptor signaling pathway involved in hemopoiesis
    positive regulation of transcription from RNA polymerase II promoter
    positive regulation of Wnt signaling pathway
    epithelial cell differentiation
    in utero embryonic development
    lung lobe morphogenesis
    bone development
    reproductive structure development
    coronal suture morphogenesis
    lung development
    negative regulation of mitotic nuclear division
    positive regulation of cell division
    fibroblast growth factor receptor signaling pathway involved in mammary gland specification
    Ras protein signal transduction
    prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis
    lung-associated mesenchyme development
    squamous basal epithelial stem cell differentiation involved in prostate gland acinus development
    digestive tract development
    multicellular organism growth
    odontogenesis
Components
    nucleoplasm
    extracellular region
    intracellular membrane-bounded organelle
    cell cortex
    nucleus
    plasma membrane
    cell surface
    integral component of plasma membrane
    Golgi apparatus
    cytoplasmic membrane-bounded vesicle
    integral component of membrane
    cytoplasm
    membrane
    excitatory synapse
General FunctionProtein tyrosine kinase activity
Specific FunctionTyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of cell proliferation, differentiation, migration and apoptosis, and in the regulation of embryonic development. Required for normal embryonic patterning, trophoblast function, limb bud development, lung morphogenesis, osteogenesis and skin development. Plays an essential role in the regulation of osteoblast differentiation, proliferation and apoptosis, and is required for normal skeleton development. Promotes cell proliferation in keratinocytes and immature osteoblasts, but promotes apoptosis in differentiated osteoblasts. Phosphorylates PLCG1, FRS2 and PAK4. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. Phosphorylation of FRS2 triggers recruitment of GRB2, GAB1, PIK3R1 and SOS1, and mediates activation of RAS, MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway. FGFR2 signaling is down-regulated by ubiquitination, internalization and degradation. Mutations that lead to constitutive kinase activation or impair normal FGFR2 maturation, internalization and degradation lead to aberrant signaling. Over-expressed FGFR2 promotes activation of STAT1.
Transmembrane Regions378-398
GenBank Protein ID31374
UniProtKB IDP21802
UniProtKB Entry NameFGFR2_HUMAN
Cellular LocationCell membrane
Gene sequence
>lcl|BSEQ0010527|Fibroblast growth factor receptor 2 (FGFR2)
ATGGTCAGCTGGGGTCGTTTCATCTGCCTGGTCGTGGTCACCATGGCAACCTTGTCCCTG
GCCCGGCCCTCCTTCAGTTTAGTTGAGGATACCACATTAGAGCCAGAAGAGCCACCAACC
AAATACCAAATCTCTCAACCAGAAGTGTACGTGGCTGCGCCAGGGGAGTCGCTAGAGGTG
CGCTGCCTGTTGAAAGATGCCGCCGTGATCAGTTGGACTAAGGATGGGGTGCACTTGGGG
CCCAACAATAGGACAGTGCTTATTGGGGAGTACTTGCAGATAAAGGGCGCCACGCCTAGA
GACTCCGGCCTCTATGCTTGTACTGCCAGTAGGACTGTAGACAGTGAAACTTGGTACTTC
ATGGTGAATGTCACAGATGCCATCTCATCCGGAGATGATGAGGATGACACCGATGGTGCG
GAAGATTTTGTCAGTGAGAACAGTAACAACAAGAGAGCACCATACTGGACCAACACAGAA
AAGATGGAAAAGCGGCTCCATGCTGTGCCTGCGGCCAACACTGTCAAGTTTCGCTGCCCA
GCCGGGGGGAACCCAATGCCAACCATGCGGTGGCTGAAAAACGGGAAGGAGTTTAAGCAG
GAGCATCGCATTGGAGGCTACAAGGTACGAAACCAGCACTGGAGCCTCATTATGGAAAGT
GTGGTCCCATCTGACAAGGGAAATTATACCTGTGTAGTGGAGAATGAATACGGGTCCATC
AATCACACGTACCACCTGGATGTTGTGGAGCGATCGCCTCACCGGCCCATCCTCCAAGCC
GGACTGCCGGCAAATGCCTCCACAGTGGTCGGAGGAGACGTAGAGTTTGTCTGCAAGGTT
TACAGTGATGCCCAGCCCCACATCCAGTGGATCAAGCACGTGGAAAAGAACGGCAGTAAA
TACGGGCCCGACGGGCTGCCCTACCTCAAGGTTCTCAAGGCCGCCGGTGTTAACACCACG
GACAAAGAGATTGAGGTTCTCTATATTCGGAATGTAACTTTTGAGGACGCTGGGGAATAT
ACGTGCTTGGCGGGTAATTCTATTGGGATATCCTTTCACTCTGCATGGTTGACAGTTCTG
CCAGCGCCTGGAAGAGAAAAGGAGATTACAGCTTCCCCAGACTACCTGGAGATAGCCATT
TACTGCATAGGGGTCTTCTTAATCGCCTGTATGGTGGTAACAGTCATCCTGTGCCGAATG
AAGAACACGACCAAGAAGCCAGACTTCAGCAGCCAGCCGGCTGTGCACAAGCTGACCAAA
CGTATCCCCCTGCGGAGACAGGTAACAGTTTCGGCTGAGTCCAGCTCCTCCATGAACTCC
AACACCCCGCTGGTGAGGATAACAACACGCCTCTCTTCAACGGCAGACACCCCCATGCTG
GCAGGGGTCTCCGAGTATGAACTTCCAGAGGACCCAAAATGGGAGTTTCCAAGAGATAAG
CTGACACTGGGCAAGCCCCTGGGAGAAGGTTGCTTTGGGCAAGTGGTCATGGCGGAAGCA
GTGGGAATTGACAAAGACAAGCCCAAGGAGGCGGTCACCGTGGCCGTGAAGATGTTGAAA
GATGATGCCACAGAGAAAGACCTTTCTGATCTGGTGTCAGAGATGGAGATGATGAAGATG
ATTGGGAAACACAAGAATATCATAAATCTTCTTGGAGCCTGCACACAGGATGGGCCTCTC
TATGTCATAGTTGAGTATGCCTCTAAAGGCAACCTCCGAGAATACCTCCGAGCCCGGAGG
CCACCCGGGATGGAGTACTCCTATGACATTAACCGTGTTCCTGAGGAGCAGATGACCTTC
AAGGACTTGGTGTCATGCACCTACCAGCTGGCCAGAGGCATGGAGTACTTGGCTTCCCAA
AAATGTATTCATCGAGATTTAGCAGCCAGAAATGTTTTGGTAACAGAAAACAATGTGATG
AAAATAGCAGACTTTGGACTCGCCAGAGATATCAACAATATAGACTATTACAAAAAGACC
ACCAATGGGCGGCTTCCAGTCAAGTGGATGGCTCCAGAAGCCCTGTTTGATAGAGTATAC
ACTCATCAGAGTGATGTCTGGTCCTTCGGGGTGTTAATGTGGGAGATCTTCACTTTAGGG
GGCTCGCCCTACCCAGGGATTCCCGTGGAGGAACTTTTTAAGCTGCTGAAGGAAGGACAC
AGAATGGATAAGCCAGCCAACTGCACCAACGAACTGTACATGATGATGAGGGACTGTTGG
CATGCAGTGCCCTCCCAGAGACCAACGTTCAAGCAGTTGGTAGAAGACTTGGATCGAATT
CTCACTCTCACAACCAATGAGGAATACTTGGACCTCAGCCAACCTCTCGAACAGTATTCA
CCTAGTTACCCTGACACAAGAAGTTCTTGTTCTTCAGGAGATGATTCTGTTTTTTCTCCA
GACCCCATGCCTTACGAACCATGCCTTCCTCAGTATCCACACATAAACGGCAGTGTTAAA
ACATGA
GenBank Gene IDX52832
GeneCard IDNone
GenAtlas IDFGFR2
HGNC IDHGNC:3689
Chromosome Location10
Locus10q26
References
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FRCD ID Name Exact Mass Structure



Heparin




340.31