D(1B) dopamine receptor


NameD(1B) dopamine receptor
SynonymsD(5) dopamine receptor D1beta dopamine receptor Dopamine D5 receptor DRD1B DRD1L2
Gene NameDRD5
OrganismHuman
Amino acid sequence
>lcl|BSEQ0009965|D(1B) dopamine receptor
MLPPGSNGTAYPGQFALYQQLAQGNAVGGSAGAPPLGPSQVVTACLLTLLIIWTLLGNVL
VCAAIVRSRHLRANMTNVFIVSLAVSDLFVALLVMPWKAVAEVAGYWPFGAFCDVWVAFD
IMCSTASILNLCVISVDRYWAISRPFRYKRKMTQRMALVMVGLAWTLSILISFIPVQLNW
HRDQAASWGGLDLPNNLANWTPWEEDFWEPDVNAENCDSSLNRTYAISSSLISFYIPVAI
MIVTYTRIYRIAQVQIRRISSLERAAEHAQSCRSSAACAPDTSLRASIKKETKVLKTLSV
IMGVFVCCWLPFFILNCMVPFCSGHPEGPPAGFPCVSETTFDVFVWFGWANSSLNPVIYA
FNADFQKVFAQLLGCSHFCSRTPVETVNISNELISYNQDIVFHKEIAAAYIHMMPNAVTP
GNREVDNDEEEGPFDRMFQIYQTSPDGDPVAESVWELDCEGEISLDKITPFTPNGFH
Number of residues477
Molecular Weight52950.5
Theoretical pI5.08
GO Classification
Functions
    G-protein coupled amine receptor activity
    dopamine binding
    dopamine neurotransmitter receptor activity
    dopamine neurotransmitter receptor activity, coupled via Gs
Processes
    norepinephrine-epinephrine vasoconstriction involved in regulation of systemic arterial blood pressure
    activation of adenylate cyclase activity
    phospholipase C-activating dopamine receptor signaling pathway
    wound healing
    adenylate cyclase-activating dopamine receptor signaling pathway
    positive regulation of adenylate cyclase activity
    sensory perception of chemical stimulus
    adenylate cyclase-activating G-protein coupled receptor signaling pathway
    regulation of female receptivity
    response to amphetamine
    associative learning
    regulation of systemic arterial blood pressure by vasopressin
    positive regulation of adenylate cyclase activity involved in G-protein coupled receptor signaling pathway
    cellular calcium ion homeostasis
    response to cocaine
    cellular response to catecholamine stimulus
    sensitization
    learning
    transmission of nerve impulse
    synaptic transmission, dopaminergic
    long term synaptic depression
    synaptic transmission
    negative regulation of blood pressure
    reactive oxygen species metabolic process
    negative regulation of NAD(P)H oxidase activity
Components
    brush border membrane
    plasma membrane
    ciliary membrane
    nonmotile primary cilium
    integral component of plasma membrane
General FunctionG-protein coupled amine receptor activity
Specific FunctionDopamine receptor whose activity is mediated by G proteins which activate adenylyl cyclase.
Transmembrane Regions40-66 78-104 115-136 159-180 224-246 297-320 341-360
GenBank Protein ID32049
UniProtKB IDP21918
UniProtKB Entry NameDRD5_HUMAN
Cellular LocationCell membrane
Gene sequence
>lcl|BSEQ0009966|D(1B) dopamine receptor (DRD5)
ATGCTGCCGCCAGGCAGCAACGGCACCGCGTACCCGGGGCAGTTCGCTCTATACCAGCAG
CTGGCGCAGGGGAACGCCGTGGGGGGCTCGGCGGGGGCACCGCCACTGGGGCCCTCACAG
GTGGTCACCGCCTGCCTGCTGACCCTACTCATCATCTGGACCCTGCTGGGCAACGTGCTG
GTGTGCGCAGCCATCGTGCGGAGCCGCCACCTGCGCGCCAACATGACCAACGTCTTCATC
GTGTCTCTGGCCGTGTCAGACCTTTTCGTGGCGCTGCTGGTCATGCCCTGGAAGGCAGTC
GCCGAGGTGGCCGGTTACTGGCCCTTTGGAGCGTTCTGCGACGTCTGGGTGGCCTTCGAC
ATCATGTGCTCCACTGCCTCCATCCTGAACCTGTGCGTCATCAGCGTGGACCGCTACTGG
GCCATCTCCAGGCCCTTCCGCTACAAGCGCAAGATGACTCAGCGCATGGCCTTGGTCATG
GTCGGCCTGGCATGGACCTTGTCCATCCTCATCTCCTTCATTCCGGTCCAGCTCAACTGG
CACAGGGACCAGGCGGCCTCTTGGGGCGGGCTGGACCTGCCAAACAACCTGGCCAACTGG
ACGCCCTGGGAGGAGGACTTTTGGGAGCCCGACGTGAATGCAGAGAACTGTGACTCCAGC
CTGAATCGAACCTACGCCATCTCTTCCTCGCTCATCAGCTTCTACATCCCCGTTGCCATC
ATGATCGTGACCTACACGCGCATCTACCGCATCGCCCAGGTGCAGATCCGCAGGATTTCC
TCCCTGGAGAGGGCCGCAGAGCACGCGCAGAGCTGCCGGAGCAGCGCAGCCTGCGCGCCC
GACACCAGCCTGCGCGCTTCCATCAAGAAGGAGACCAAGGTTCTCAAGACCCTGTCGGTG
ATCATGGGGGTCTTCGTGTGTTGCTGGCTGCCCTTCTTCATCCTTAACTGCATGGTCCCT
TTCTGCAGTGGACACCCCGAAGGCCCTCCGGCCGGCTTCCCCTGCGTCAGTGAGACCACC
TTCGACGTCTTCGTCTGGTTCGGCTGGGCTAACTCCTCACTCAACCCCGTCATCTATGCC
TTCAACGCCGACTTTCAGAAGGTGTTTGCCCAGCTGCTGGGGTGCAGCCACTTCTGCTCC
CGCACGCCGGTGGAGACGGTGAACATCAGCAATGAGCTCATCTCCTACAACCAAGACATC
GTCTTCCACAAGGAAATCGCAGCTGCCTACATCCACATGATGCCCAACGCCGTTACCCCC
GGCAACCGGGAGGTGGACAACGACGAGGAGGAGGGTCCTTTCGATCGCATGTTCCAGATC
TATCAGACGTCCCCAGATGGTGACCCTGTTGCTGAGTCTGTCTGGGAGCTGGACTGCGAG
GGGGAGATTTCTTTAGACAAAATAACACCTTTCACCCCGAATGGATTCCATTAA
GenBank Gene IDX58454
GeneCard IDNone
GenAtlas IDDRD5
HGNC IDHGNC:3026
Chromosome Location4
Locus4p16.1
References
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  2. Sunahara RK, Guan HC, O'Dowd BF, Seeman P, Laurier LG, Ng G, George SR, Torchia J, Van Tol HH, Niznik HB: Cloning of the gene for a human dopamine D5 receptor with higher affinity for dopamine than D1. Nature. 1991 Apr 18;350(6319):614-9.[1826762 ]
  3. Grandy DK, Zhang YA, Bouvier C, Zhou QY, Johnson RA, Allen L, Buck K, Bunzow JR, Salon J, Civelli O: Multiple human D5 dopamine receptor genes: a functional receptor and two pseudogenes. Proc Natl Acad Sci U S A. 1991 Oct 15;88(20):9175-9.[1833775 ]
  4. Weinshank RL, Adham N, Macchi M, Olsen MA, Branchek TA, Hartig PR: Molecular cloning and characterization of a high affinity dopamine receptor (D1 beta) and its pseudogene. J Biol Chem. 1991 Nov 25;266(33):22427-35.[1834671 ]
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  6. Karpa KD, Lidow MS, Pickering MT, Levenson R, Bergson C: N-linked glycosylation is required for plasma membrane localization of D5, but not D1, dopamine receptors in transfected mammalian cells. Mol Pharmacol. 1999 Nov;56(5):1071-8.[10531415 ]
  7. Misbahuddin A, Placzek MR, Chaudhuri KR, Wood NW, Bhatia KP, Warner TT: A polymorphism in the dopamine receptor DRD5 is associated with blepharospasm. Neurology. 2002 Jan 8;58(1):124-6.[11781417 ]
  8. Sobell JL, Lind TJ, Sigurdson DC, Zald DH, Snitz BE, Grove WM, Heston LL, Sommer SS: The D5 dopamine receptor gene in schizophrenia: identification of a nonsense change and multiple missense changes but lack of association with disease. Hum Mol Genet. 1995 Apr;4(4):507-14.[7633397 ]
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Related FRC


FRCD ID Name Exact Mass Structure



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383.51



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Olanzapine




312.435



Risperidone




410.493



L-Dopa




197.19



Agroclavine




238.334



Elymoclavine




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Nantenine




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Dopamine




153.181