Lactoperoxidase

NameLactoperoxidase
Synonyms1.11.1.7 LPO Salivary peroxidase SAPX SPO
Gene NameLPO
OrganismHuman
Amino acid sequence
>lcl|BSEQ0008949|Lactoperoxidase
MRVLLHLPALLASLILLQAAASTTRAQTTRTSAISDTVSQAKVQVNKAFLDSRTRLKTAM
SSETPTSRQLSEYLKHAKGRTRTAIRNGQVWEESLKRLRQKASLTNVTDPSLDLTSLSLE
VGCGAPAPVVRCDPCSPYRTITGDCNNRRKPALGAANRALARWLPAEYEDGLSLPFGWTP
GKTRNGFPLPLAREVSNKIVGYLNEEGVLDQNRSLLFMQWGQIVDHDLDFAPDTELGSSE
YSKAQCDEYCIQGDNCFPIMFPPNDPKAGTQGKCMPFFRAGFVCPTPPYKSLAREQINAL
TSFLDASFVYSSEPSLASRLRNLSSPLGLMAVNQEVSDHGLPYLPYDSKKPSPCEFINTT
ARVPCFLAGDSRASEHILLATSHTLFLREHNRLARELKRLNPQWDGEKLYQEARKILGAF
VQIITFRDYLPILLGDHMQKWIPPYQGYSESVDPRISNVFTFAFRFGHLEVPSSMFRLDE
NYQPWGPEPELPLHTLFFNTWRMVKDGGIDPLVRGLLAKKSKLMKQNKMMTGELRNKLFQ
PTHRIHGFDLAAINTQRCRDHGQPGYNSWRAFCDLSQPQTLEELNTVLKSKMLAKKLLGL
YGTPDNIDIWIGAIAEPLVERGRVGPLLACLLGKQFQQIRDGDRFWWENPGVFTNEQKDS
LQKMSFSRLVCDNTRITKVPRDPFWANSYPYDFVDCSAIDKLDLSPWASVKN
Number of residues712
Molecular Weight80287.055
Theoretical pINone
GO Classification
Functions
    thiocyanate peroxidase activity
heme binding
metal ion binding
Processes
    defense response to bacterium
hydrogen peroxide catabolic process
detection of chemical stimulus involved in sensory perception of bitter taste
thiocyanate metabolic process
response to oxidative stress
Components
    extracellular exosome
basolateral plasma membrane
cytoplasm
extracellular space
General FunctionThiocyanate peroxidase activity
Specific FunctionAntimicrobial agent which utilizes hydrogen peroxide and thiocyanate (SCN) to generate the antimicrobial substance hypothiocyanous acid (HOSCN) (By similarity). May contribute to airway host defense against infection.
Transmembrane Regions
GenBank Protein ID
UniProtKB IDP22079
UniProtKB Entry NamePERL_HUMAN
Cellular LocationSecreted
Gene sequence
>lcl|BSEQ0017650|Lactoperoxidase (LPO)
ATGAGGGTCCTTCTCCATCTCCCAGCCCTCCTGGCTTCCCTCATCTTGCTTCAGGCTGCA
GCATCTACCACAAGAGATCCCAGCCTGGACTTGACTTCACTGTCTCTGGAGGTGGGCTGT
GGTGCTCCTGCTCCCGTGGTGAGATGCGACCCGTGCAGCCCTTACCGCACCATTACGGGA
GACTGCAATAACAGGAGGAAGCCTGCGCTGGGCGCCGCCAACAGGGCTCTGGCGCGCTGG
CTGCCCGCGGAGTACGAGGACGGGCTCTCCCTGCCCTTCGGCTGGACGCCGGGGAAGACG
CGCAACGGCTTCCCTCTCCCGCTGGCCCGGGAGGTATCTAACAAGATTGTTGGCTATCTG
AATGAGGAGGGTGTTCTGGACCAAAACAGGTCCCTGCTCTTCATGCAGTGGGGTCAGATT
GTGGATCATGACCTGGACTTTGCCCCTGACACCGAGCTGGGGAGTAGCGAGTACTCCAAA
GCCCAGTGTGATGAGTACTGTATCCAGGGAGACAACTGCTTCCCCATCATGTTCCCACCC
AATGACCCCAAGGCGGGGACTCAAGGGAAATGCATGCCTTTCTTCCGAGCTGGGTTCGTC
TGCCCCACTCCACCCTACAAGTCCCTGGCCCGAGAGCAGATCAACGCTCTGACCTCCTTC
CTGGATGCCAGCTTTGTGTACAGCTCCGAGCCAAGCCTGGCCAGCCGCCTCCGCAACCTC
AGCAGCCCCCTGGGCCTCATGGCTGTCAACCAGGAGGTCTCAGACCATGGACTACCCTAC
CTGCCCTATGACAGCAAGAAGCCAAGCCCCTGTGAGTTCATCAACACCACTGCCCGTGTG
CCCTGCTTCCTGGCAGGAGATTCTCGAGCCTCAGAGCATATTCTGCTGGCCACATCCCAC
ACCCTCTTTCTCCGCGAGCATAACCGGCTGGCCAGAGAACTAAAGAGACTCAACCCTCAG
TGGGATGGAGAGAAGCTCTACCAGGAAGCCCGGAAAATCCTGGGAGCCTTCGTGCAGATT
ATCACCTTTAGGGACTACCTACCCATTTTGCTAGGTGACCACATGCAGAAGTGGATACCC
CCATATCAAGGCTACAGTGAATCTGTGGATCCCAGAATTTCCAATGTCTTCACCTTCGCC
TTCCGCTTTGGCCACTTGGAGGTCCCCTCTAGTATGTTCCGCCTGGATGAGAATTATCAG
CCATGGGGGCCAGAACCAGAACTCCCCCTCCACACCCTCTTCTTCAACACTTGGAGGATG
GTCAAAGATGGTGGAATTGATCCTCTGGTGCGGGGCCTGCTGGCCAAGAAATCCAAGCTG
ATGAAACAGAATAAAATGATGACTGGAGAGCTGCGCAACAAGCTTTTCCAGCCAACTCAC
AGGATCCATGGCTTTGACCTGGCTGCCATCAACACACAGCGTTGCCGGGACCATGGGCAA
CCTGGGTACAATTCCTGGAGAGCCTTCTGTGACCTCTCACAGCCGCAGACACTAGAGGAG
TTGAACACAGTGCTGAAGAGCAAGATGCTGGCCAAGAAGTTACTGGGTCTCTACGGGACC
CCTGACAACATCGACATCTGGATAGGGGCCATTGCTGAGCCGCTGGTGGAAAGGGGTCGG
GTGGGGCCTCTCCTGGCCTGCCTCTTGGGCAAGCAGTTCCAGCAGATCCGTGATGGAGAC
AGGTTCTGGTGGGAAAACCCTGGGGTCTTCACGAACGAGCAGAAGGACTCTCTACAGAAA
ATGTCCTTCTCACGCCTTGTCTGTGACAACACCCGCATCACCAAGGTCCCACGGGACCCA
TTCTGGGCCAACAGCTACCCCTATGACTTCGTGGATTGCTCAGCCATCGACAAGCTGGAC
CTGTCACCCTGGGCCTCAGTGAAGAATTAG
GenBank Gene ID
GeneCard IDNone
GenAtlas ID
HGNC IDHGNC:6678
Chromosome Location17
LocusNone
References
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  2. Kiser C, Caterina CK, Engler JA, Rahemtulla B, Rahemtulla F: Cloning and sequence analysis of the human salivary peroxidase-encoding cDNA. Gene. 1996 Sep 16;173(2):261-4.[8964511 ]
  3. Fragoso MA, Torbati A, Fregien N, Conner GE: Molecular heterogeneity and alternative splicing of human lactoperoxidase. Arch Biochem Biophys. 2009 Feb;482(1-2):52-7. doi: 10.1016/j.abb.2008.11.015. Epub 2008 Nov 24.[19059195 ]
  4. Zody MC, Garber M, Adams DJ, Sharpe T, Harrow J, Lupski JR, Nicholson C, Searle SM, Wilming L, Young SK, Abouelleil A, Allen NR, Bi W, Bloom T, Borowsky ML, Bugalter BE, Butler J, Chang JL, Chen CK, Cook A, Corum B, Cuomo CA, de Jong PJ, DeCaprio D, Dewar K, FitzGerald M, Gilbert J, Gibson R, Gnerre S, Goldstein S, Grafham DV, Grocock R, Hafez N, Hagopian DS, Hart E, Norman CH, Humphray S, Jaffe DB, Jones M, Kamal M, Khodiyar VK, LaButti K, Laird G, Lehoczky J, Liu X, Lokyitsang T, Loveland J, Lui A, Macdonald P, Major JE, Matthews L, Mauceli E, McCarroll SA, Mihalev AH, Mudge J, Nguyen C, Nicol R, O'Leary SB, Osoegawa K, Schwartz DC, Shaw-Smith C, Stankiewicz P, Steward C, Swarbreck D, Venkataraman V, Whittaker CA, Yang X, Zimmer AR, Bradley A, Hubbard T, Birren BW, Rogers J, Lander ES, Nusbaum C: DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage. Nature. 2006 Apr 20;440(7087):1045-9.[16625196 ]
  5. Dull TJ, Uyeda C, Strosberg AD, Nedwin G, Seilhamer JJ: Molecular cloning of cDNAs encoding bovine and human lactoperoxidase. DNA Cell Biol. 1990 Sep;9(7):499-509.[2222811 ]
  6. Wijkstrom-Frei C, El-Chemaly S, Ali-Rachedi R, Gerson C, Cobas MA, Forteza R, Salathe M, Conner GE: Lactoperoxidase and human airway host defense. Am J Respir Cell Mol Biol. 2003 Aug;29(2):206-12. Epub 2003 Mar 6.[12626341 ]
  7. Ramachandran P, Boontheung P, Xie Y, Sondej M, Wong DT, Loo JA: Identification of N-linked glycoproteins in human saliva by glycoprotein capture and mass spectrometry. J Proteome Res. 2006 Jun;5(6):1493-503.[16740002 ]
  8. Picariello G, Ferranti P, Mamone G, Roepstorff P, Addeo F: Identification of N-linked glycoproteins in human milk by hydrophilic interaction liquid chromatography and mass spectrometry. Proteomics. 2008 Sep;8(18):3833-47. doi: 10.1002/pmic.200701057.[18780401 ]

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FRCD ID Name Exact Mass Structure




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