Acetylcholinesterase


NameAcetylcholinesterase
Synonyms3.1.1.7 AChE
Gene NameACHE
OrganismHuman
Amino acid sequence
>lcl|BSEQ0000849|Acetylcholinesterase
MRPPQCLLHTPSLASPLLLLLLWLLGGGVGAEGREDAELLVTVRGGRLRGIRLKTPGGPV
SAFLGIPFAEPPMGPRRFLPPEPKQPWSGVVDATTFQSVCYQYVDTLYPGFEGTEMWNPN
RELSEDCLYLNVWTPYPRPTSPTPVLVWIYGGGFYSGASSLDVYDGRFLVQAERTVLVSM
NYRVGAFGFLALPGSREAPGNVGLLDQRLALQWVQENVAAFGGDPTSVTLFGESAGAASV
GMHLLSPPSRGLFHRAVLQSGAPNGPWATVGMGEARRRATQLAHLVGCPPGGTGGNDTEL
VACLRTRPAQVLVNHEWHVLPQESVFRFSFVPVVDGDFLSDTPEALINAGDFHGLQVLVG
VVKDEGSYFLVYGAPGFSKDNESLISRAEFLAGVRVGVPQVSDLAAEAVVLHYTDWLHPE
DPARLREALSDVVGDHNVVCPVAQLAGRLAAQGARVYAYVFEHRASTLSWPLWMGVPHGY
EIEFIFGIPLDPSRNYTAEEKIFAQRLMRYWANFARTGDPNEPRDPKAPQWPPYTAGAQQ
YVSLDLRPLEVRRGLRAQACAFWNRFLPKLLSATDTLDEAERQWKAEFHRWSSYMVHWKN
QFDHYSKQDRCSDL
Number of residues614
Molecular Weight67795.525
Theoretical pI6.24
GO Classification
Functions
    cholinesterase activity
    acetylcholine binding
    hydrolase activity
    acetylcholinesterase activity
    beta-amyloid binding
    laminin binding
    serine hydrolase activity
    protein homodimerization activity
    collagen binding
Processes
    amyloid precursor protein metabolic process
    protein tetramerization
    synapse assembly
    muscle organ development
    synaptic transmission
    negative regulation of synaptic transmission, cholinergic
    neurotransmitter receptor biosynthetic process
    nervous system development
    cell proliferation
    osteoblast development
    response to wounding
    phosphatidylcholine biosynthetic process
    neurotransmitter biosynthetic process
    cell adhesion
    positive regulation of protein secretion
    glycerophospholipid biosynthetic process
    small molecule metabolic process
    regulation of receptor recycling
    phospholipid metabolic process
    retina development in camera-type eye
    DNA replication
    acetylcholine catabolic process
    acetylcholine catabolic process in synaptic cleft
    receptor internalization
Components
    anchored component of membrane
    extracellular space
    synapse
    basal lamina
    neuromuscular junction
    cell surface
    synaptic cleft
    membrane
    cell junction
    Golgi apparatus
    extracellular region
    nucleus
    perinuclear region of cytoplasm
    plasma membrane
General FunctionSerine hydrolase activity
Specific FunctionTerminates signal transduction at the neuromuscular junction by rapid hydrolysis of the acetylcholine released into the synaptic cleft. Role in neuronal apoptosis.
Transmembrane Regions
GenBank Protein ID177975
UniProtKB IDP22303
UniProtKB Entry NameACES_HUMAN
Cellular LocationCell junction
Gene sequence
>lcl|BSEQ0010296|Acetylcholinesterase (ACHE)
ATGAGGCCCCCGCAGTGTCTGCTGCACACGCCTTCCCTGGCTTCCCCACTCCTTCTCCTC
CTCCTCTGGCTCCTGGGTGGAGGAGTGGGGGCTGAGGGCCGGGAGGATGCAGAGCTGCTG
GTGACGGTGCGTGGGGGCCGGCTGCGGGGCATTCGCCTGAAGACCCCCGGGGGCCCTGTC
TCTGCTTTCCTGGGCATCCCCTTTGCGGAGCCACCCATGGGACCCCGTCGCTTTCTGCCA
CCGGAGCCCAAGCAGCCTTGGTCAGGGGTGGTAGACGCTACAACCTTCCAGAGTGTCTGC
TACCAATATGTGGACACCCTATACCCAGGTTTTGAGGGCACCGAGATGTGGAACCCCAAC
CGTGAGCTGAGCGAGGACTGCCTGTACCTCAACGTGTGGACACCATACCCCCGGCCTACA
TCCCCCACCCCTGTCCTCGTCTGGATCTATGGGGGTGGCTTCTACAGTGGGGCCTCCTCC
TTGGACGTGTACGATGGCCGCTTCTTGGTACAGGCCGAGAGGACTGTGCTGGTGTCCATG
AACTACCGGGTGGGAGCCTTTGGCTTCCTGGCCCTGCCGGGGAGCCGAGAGGCCCCGGGC
AATGTGGGTCTCCTGGATCAGAGGCTGGCCCTGCAGTGGGTGCAGGAGAACGTGGCAGCC
TTCGGGGGTGACCCGACATCAGTGACGCTGTTTGGGGAGAGCGCGGGAGCCGCCTCGGTG
GGCATGCACCTGCTGTCCCCGCCCAGCCGGGGCCTGTTCCACAGGGCCGTGCTGCAGAGC
GGTGCCCCCAATGGACCCTGGGCCACGGTGGGCATGGGAGAGGCCCGTCGCAGGGCCACG
CAGCTGGCCCACCTTGTGGGCTGTCCTCCAGGCGGCACTGGTGGGAATGACACAGAGCTG
GTAGCCTGCCTTCGGACACGACCAGCGCAGGTCCTGGTGAACCACGAATGGCACGTGCTG
CCTCAAGAAAGCGTCTTCCGGTTCTCCTTCGTGCCTGTGGTAGATGGAGACTTCCTCAGT
GACACCCCAGAGGCCCTCATCAACGCGGGAGACTTCCACGGCCTGCAGGTGCTGGTGGGT
GTGGTGAAGGATGAGGGCTCGTATTTTCTGGTTTACGGGGCCCCAGGCTTCAGCAAAGAC
AACGAGTCTCTCATCAGCCGGGCCGAGTTCCTGGCCGGGGTGCGGGTCGGGGTTCCCCAG
GTAAGTGACCTGGCAGCCGAGGCTGTGGTCCTGCATTACACAGACTGGCTGCATCCCGAG
GACCCGGCACGCCTGAGGGAGGCCCTGAGCGATGTGGTGGGCGACCACAATGTCGTGTGC
CCCGTGGCCCAGCTGGCTGGGCGACTGGCTGCCCAGGGTGCCCGGGTCTACGCCTACGTC
TTTGAACACCGTGCTTCCACGCTCTCCTGGCCCCTGTGGATGGGGGTGCCCCACGGCTAC
GAGATCGAGTTCATCTTTGGGATCCCCCTGGACCCCTCTCGAAACTACACGGCAGAGGAG
AAAATCTTCGCCCAGCGACTGATGCGATACTGGGCCAACTTTGCCCGCACAGGGGATCCC
AATGAGCCCCGAGACCCCAAGGCCCCACAATGGCCCCCGTACACGGCGGGGGCTCAGCAG
TACGTTAGTCTGGACCTGCGGCCGCTGGAGGTGCGGCGGGGGCTGCGCGCCCAGGCCTGC
GCCTTCTGGAACCGCTTCCTCCCCAAATTGCTCAGCGCCACCGACACGCTCGACGAGGCG
GAGCGCCAGTGGAAGGCCGAGTTCCACCGCTGGAGCTCCTACATGGTGCACTGGAAGAAC
CAGTTCGACCACTACAGCAAGCAGGATCGCTGCTCAGACCTGTGA
GenBank Gene IDM55040
GeneCard IDNone
GenAtlas IDACHE
HGNC IDHGNC:108
Chromosome Location7
Locus7q22
References
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  3. Karpel R, Ben Aziz-Aloya R, Sternfeld M, Ehrlich G, Ginzberg D, Tarroni P, Clementi F, Zakut H, Soreq H: Expression of three alternative acetylcholinesterase messenger RNAs in human tumor cell lines of different tissue origins. Exp Cell Res. 1994 Feb;210(2):268-77.[8299725 ]
  4. Bartels CF, Zelinski T, Lockridge O: Mutation at codon 322 in the human acetylcholinesterase (ACHE) gene accounts for YT blood group polymorphism. Am J Hum Genet. 1993 May;52(5):928-36.[8488842 ]
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  8. Chhajlani V, Derr D, Earles B, Schmell E, August T: Purification and partial amino acid sequence analysis of human erythrocyte acetylcholinesterase. FEBS Lett. 1989 Apr 24;247(2):279-82.[2714437 ]
  9. Velan B, Grosfeld H, Kronman C, Leitner M, Gozes Y, Lazar A, Flashner Y, Marcus D, Cohen S, Shafferman A: The effect of elimination of intersubunit disulfide bonds on the activity, assembly, and secretion of recombinant human acetylcholinesterase. Expression of acetylcholinesterase Cys-580----Ala mutant. J Biol Chem. 1991 Dec 15;266(35):23977-84.[1748670 ]
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Related FRC


FRCD ID Name Exact Mass Structure



Alternariol




258.229



Territrem B




526.582



Territrem A




510.539



Territrem C




512.555



Azamethiphos




324.672



Mevinphos




224.15



Benzophenone




182.222



Lycorine




287.315



Clomazone




239.699



Quinone




108.096



Toxaphene




411.774



Disulfoton




274.392



Aminocarb




208.261



Diazinon




304.35



Chlorpyrifos




350.575



Guthion




317.318



Phorate




260.4



Carbofuran




221.256



Metolcarb




165.192



Nitrilacarb




197.238



Phenmedipham




300.314



Alanycarb




399.524



Aldoxycarb




222.259



Benthiavalicarb-isopropyl




381.466



Cypendazole




329.36



Ethiofencarb




225.306



Trimethacarb




193.246



Donepezil




379.5



Diacetyl




86.09



Fenthion




278.321



1,2-Naphthoquinone




158.156



Pentachlorophenol




266.323



Isolan




211.265



Toluene




92.141



Thiofanox




218.315



2,4,6-Trichlorophenol




197.439



1,1,1-Trichloroethane




133.396



Parathion




291.258



2,4,5-Trichlorophenol




197.439



Dimethoate




229.3



(±)-Naled




380.778



Ethoprop




242.332



Propham




179.219



Propoxur




209.245



Pyrolan




245.282



Thiocarboxime




201.244



Isoimperatorin




270.28



Methoxsalen




216.19



Allyxycarb




274.364



Asulam




230.238



Barban




258.098



Bendiocarb




223.228



Benfuracarb




410.529



Butacarb




263.381



Butocarboxim




190.261



Butoxycarboxim




222.259



Carbanolate




213.661



Carbaril




201.225



Carbasulam




288.274



Carbosulfan




380.547



Carboxazole




198.222



Chlorprocarb




266.297



Chlorpropham




213.661



Cloethocarb




259.686



Dimetan




211.261



Debacarb




293.323



Decarbofuran




207.229



Desmedipham




300.314



Dichlormate




234.076



Diethofencarb




267.325



Dimetilan




240.263



Dioxacarb




223.228



Fenasulam




412.841



Fenethacarb




207.273



Fenobucarb




207.273



Fenoxycarb




301.342



Hyquincarb




234.299



Formetanate




221.26



Formparanate




271.745



Furathiocarb




382.475



Karbutilate




279.34



Methiocarb




225.306



Mexacarbate




222.288



Mobam




207.247



Oms 22




227.688



Promacyl




277.364



Pirimicarb




238.291



Promecarb




207.273



Propamocarb




188.271



Proximphan




192.218



Sulfocarbathione




211.312



Swep




220.049



Tazimcarb




231.27



Terbucarb




277.408



Thiobencarb




257.776



Xylylcarb




179.219



Tubocurarine




609.743