Solute carrier family 2, facilitated glucose transporter member 5


NameSolute carrier family 2, facilitated glucose transporter member 5
SynonymsFructose transporter Glucose transporter type 5, small intestine GLUT-5 GLUT5
Gene NameSLC2A5
OrganismHuman
Amino acid sequence
>lcl|BSEQ0008980|Solute carrier family 2, facilitated glucose transporter member 5
MEQQDQSMKEGRLTLVLALATLIAAFGSSFQYGYNVAAVNSPALLMQQFYNETYYGRTGE
FMEDFPLTLLWSVTVSMFPFGGFIGSLLVGPLVNKFGRKGALLFNNIFSIVPAILMGCSR
VATSFELIIISRLLVGICAGVSSNVVPMYLGELAPKNLRGALGVVPQLFITVGILVAQIF
GLRNLLANVDGWPILLGLTGVPAALQLLLLPFFPESPRYLLIQKKDEAAAKKALQTLRGW
DSVDREVAEIRQEDEAEKAAGFISVLKLFRMRSLRWQLLSIIVLMGGQQLSGVNAIYYYA
DQIYLSAGVPEEHVQYVTAGTGAVNVVMTFCAVFVVELLGRRLLLLLGFSICLIACCVLT
AALALQDTVSWMPYISIVCVISYVIGHALGPSPIPALLITEIFLQSSRPSAFMVGGSVHW
LSNFTVGLIFPFIQEGLGPYSFIVFAVICLLTTIYIFLIVPETKAKTFIEINQIFTKMNK
VSEVYPEKEELKELPPVTSEQ
Number of residues501
Molecular Weight54973.42
Theoretical pINone
GO Classification
Functions
    glucose transmembrane transporter activity
    fructose transmembrane transporter activity
Processes
    transmembrane transport
    glucose transport
    fructose transport
    hexose transport
    glucose transmembrane transport
    cellular response to fructose stimulus
    small molecule metabolic process
    carbohydrate metabolic process
Components
    apical plasma membrane
    plasma membrane
    integral component of membrane
    extracellular exosome
General FunctionGlucose transmembrane transporter activity
Specific FunctionCytochalasin B-sensitive carrier. Seems to function primarily as a fructose transporter.
Transmembrane Regions13-33 69-89 99-119 121-141 162-182 193-213 278-298 319-339 343-363 369-389 413-433 440-460
GenBank Protein ID
UniProtKB IDP22732
UniProtKB Entry NameGTR5_HUMAN
Cellular LocationApical cell membrane
Gene sequence
>lcl|BSEQ0017662|Solute carrier family 2, facilitated glucose transporter member 5 (SLC2A5)
ATGGAGCAACAGGATCAGAGCATGAAGGAAGGGAGGCTGACGCTTGTGCTTGCCCTGGCA
ACCCTGATAGCTGCCTTTGGGTCATCCTTCCAGTATGGGTACAACGTGGCTGCTGTCAAC
TCCCCAGCACTGCTCATGCAACAATTTTACAATGAGACTTACTATGGTAGGACCGGTGAA
TTCATGGAAGACTTCCCCTTGACGTTGCTGTGGTCTGTAACCGTGTCCATGTTTCCATTT
GGAGGGTTTATCGGATCCCTCCTGGTCGGCCCCTTGGTGAATAAATTTGGCAGAAAAGGG
GCCTTGCTGTTCAACAACATATTTTCTATCGTGCCTGCGATCTTAATGGGATGCAGCAGA
GTCGCCACATCATTTGAGCTTATCATTATTTCCAGACTTTTGGTGGGAATATGTGCAGGT
GTATCTTCCAACGTGGTCCCCATGTACTTAGGGGAGCTGGCCCCTAAAAACCTGCGGGGG
GCTCTCGGGGTGGTGCCCCAGCTCTTCATCACTGTTGGCATCCTTGTGGCCCAGATCTTT
GGTCTTCGGAATCTCCTTGCAAACGTAGATGGTGAGTTCAGGACATCTCGGGAGCACCCC
CACCCCTTCACCACTACCCTTGGCCCCCTCCTTGTGTTCCAAAGCCACCACCACAGGACA
GGACTTTCTGCAGACTGGTCTCTTCTAACAGGCTGGATGTCCTTGGGGGGCCCATCCTGT
CCCGAGCCAACATAG
GenBank Gene ID
GeneCard IDNone
GenAtlas ID
HGNC IDHGNC:11010
Chromosome Location1
LocusNone
References
  1. Kayano T, Burant CF, Fukumoto H, Gould GW, Fan YS, Eddy RL, Byers MG, Shows TB, Seino S, Bell GI: Human facilitative glucose transporters. Isolation, functional characterization, and gene localization of cDNAs encoding an isoform (GLUT5) expressed in small intestine, kidney, muscle, and adipose tissue and an unusual glucose transporter pseudogene-like sequence (GLUT6). J Biol Chem. 1990 Aug 5;265(22):13276-82.[1695905 ]
  2. Van Damme P, Lasa M, Polevoda B, Gazquez C, Elosegui-Artola A, Kim DS, De Juan-Pardo E, Demeyer K, Hole K, Larrea E, Timmerman E, Prieto J, Arnesen T, Sherman F, Gevaert K, Aldabe R: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB. Proc Natl Acad Sci U S A. 2012 Jul 31;109(31):12449-54. doi: 10.1073/pnas.1210303109. Epub 2012 Jul 18.[22814378 ]
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