Ferrochelatase, mitochondrial


NameFerrochelatase, mitochondrial
Synonyms4.99.1.1 Heme synthase Protoheme ferro-lyase
Gene NameFECH
OrganismHuman
Amino acid sequence
>lcl|BSEQ0002057|Ferrochelatase, mitochondrial
MRSLGANMAAALRAAGVLLRDPLASSSWRVCQPWRWKSGAAAAAVTTETAQHAQGAKPQV
QPQKRKPKTGILMLNMGGPETLGDVHDFLLRLFLDRDLMTLPIQNKLAPFIAKRRTPKIQ
EQYRRIGGGSPIKIWTSKQGEGMVKLLDELSPNTAPHKYYIGFRYVHPLTEEAIEEMERD
GLERAIAFTQYPQYSCSTTGSSLNAIYRYYNQVGRKPTMKWSTIDRWPTHHLLIQCFADH
ILKELDHFPLEKRSEVVILFSAHSLPMSVVNRGDPYPQEVSATVQKVMERLEYCNPYRLV
WQSKVGPMPWLGPQTDESIKGLCERGRKNILLVPIAFTSDHIETLYELDIEYSQVLAKEC
GVENIRRAESLNGNPLFSKALADLVHSHIQSNELCSKQLTLSCPLCVNPVCRETKSFFTS
QQL
Number of residues423
Molecular Weight47861.77
Theoretical pI8.91
GO Classification
Functions
    ferrous iron binding
    2 iron, 2 sulfur cluster binding
    heme binding
    iron-responsive element binding
    ferrochelatase activity
Processes
    response to light stimulus
    response to platinum ion
    small molecule metabolic process
    response to lead ion
    generation of precursor metabolites and energy
    regulation of gene expression
    very-low-density lipoprotein particle assembly
    cholesterol metabolic process
    response to insecticide
    response to ethanol
    iron ion homeostasis
    cellular response to dexamethasone stimulus
    erythrocyte differentiation
    response to methylmercury
    protoporphyrinogen IX metabolic process
    response to drug
    heme biosynthetic process
    regulation of eIF2 alpha phosphorylation by heme
    porphyrin-containing compound metabolic process
    detection of UV
    response to arsenic-containing substance
    regulation of hemoglobin biosynthetic process
Components
    mitochondrion
    mitochondrial inner membrane
    mitochondrial matrix
General FunctionIron-responsive element binding
Specific FunctionCatalyzes the ferrous insertion into protoporphyrin IX.
Transmembrane Regions
GenBank Protein ID219656
UniProtKB IDP22830
UniProtKB Entry NameHEMH_HUMAN
Cellular LocationMitochondrion inner membrane
Gene sequence
>lcl|BSEQ0019053|Ferrochelatase, mitochondrial (FECH)
ATGCGTTCACTCGGCGCAAACATGGCTGCGGCCCTGCGCGCCGCGGGCGTCCTGCTCCGC
GATCCGCTGGCATCCAGCAGCTGGAGGGTCTGTCAGCCATGGAGGTGGAAGTCAGGTGCA
GCTGCAGCGGCCGTCACCACAGAAACAGCCCAGCATGCCCAGGGTGCAAAACCTCAAGTT
CAACCGCAGAAGAGGAAGCCGAAAACTGGAATATTAATGCTAAACATGGGAGGCCCTGAA
ACTCTTGGAGATGTTCACGACTTCCTTCTGAGACTCTTCTTGGACCGAGACCTCATGACA
CTTCCTATTCAGAATAAGCTGGCACCATTCATCGCCAAACGCCGAACCCCCAAGATTCAA
GAGCAGTACCGCAGGATTGGAGGCGGATCCCCCATCAAGATATGGACTTCCAAGCAGGGA
GAGGGCATGGTGAAGCTGCTGGATGAATTGTCCCCCAACACAGCCCCTCACAAATACTAT
ATTGGATTTCGGTACGTCCATCCTTTAACAGAAGAAGCAATTGAAGAGATGGAGAGAGAT
GGCCTAGAAAGGGCTATTGCTTTCACACAGTATCCACAGTACAGCTGCTCCACCACAGGC
AGCAGCTTAAATGCCATTTACAGATACTATAATCAAGTGGGACGGAAGCCCACGATGAAG
TGGAGCACTATTGACAGGTGGCCCACACATCACCTCCTCATCCAGTGCTTTGCAGATCAT
ATTCTAAAGGAACTGGACCATTTTCCACTTGAGAAGAGAAGCGAGGTGGTCATTCTGTTT
TCTGCTCACTCACTGCCCATGTCTGTGGTCAACAGAGGCGACCCATATCCTCAGGAGGTA
AGCGCCACTGTCCAAAAAGTCATGGAAAGGCTGGAGTACTGCAACCCCTACCGACTGGTG
TGGCAATCCAAGGTTGGTCCAATGCCCTGGTTGGGTCCTCAAACAGACGAATCTATCAAA
GGGCTTTGTGAGAGGGGGAGGAAGAATATCCTCTTGGTTCCGATAGCATTTACCAGTGAC
CATATTGAAACGCTGTATGAGCTGGACATCGAGTACTCTCAAGTTTTAGCCAAGGAGTGT
GGAGTTGAAAACATCAGAAGAGCTGAGTCTCTTAATGGAAATCCATTGTTCTCTAAGGCC
CTGGCCGACTTGGTGCATTCACACATCCAGTCAAACGAGCTGTGTTCCAAGCAGCTGACC
CTGAGCTGTCCGCTCTGTGTCAATCCTGTCTGCAGGGAGACTAAATCCTTCTTCACCAGC
CAGCAGCTGTGA
GenBank Gene IDD00726
GeneCard IDNone
GenAtlas IDFECH
HGNC IDHGNC:3647
Chromosome Location18
Locus18q21.3
References
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