Gamma-aminobutyric acid receptor subunit rho-1


NameGamma-aminobutyric acid receptor subunit rho-1
SynonymsGABA(A) receptor subunit rho-1 GABA(C) receptor
Gene NameGABRR1
OrganismHuman
Amino acid sequence
>lcl|BSEQ0036955|Gamma-aminobutyric acid receptor subunit rho-1
MLAVPNMRFGIFLLWWGWVLATESRMHWPGREVHEMSKKGRPQRQRREVHEDAHKQVSPI
LRRSPDITKSPLTKSEQLLRIDDHDFSMRPGFGGPAIPVGVDVQVESLDSISEVDMDFTM
TLYLRHYWKDERLSFPSTNNLSMTFDGRLVKKIWVPDMFFVHSKRSFIHDTTTDNVMLRV
QPDGKVLYSLRVTVTAMCNMDFSRFPLDTQTCSLEIESYAYTEDDLMLYWKKGNDSLKTD
ERISLSQFLIQEFHTTTKLAFYSSTGWYNRLYINFTLRRHIFFFLLQTYFPATLMVMLSW
VSFWIDRRAVPARVPLGITTVLTMSTIITGVNASMPRVSYIKAVDIYLWVSFVFVFLSVL
EYAAVNYLTTVQERKEQKLREKLPCTSGLPPPRTAMLDGNYSDGEVNDLDNYMPENGEKP
DRMMVQLTLASERSSPQRKSQRSSYVSMRIDTHAIDKYSRIIFPAAYILFNLIYWSIFS
Number of residues479
Molecular Weight55882.91
Theoretical pI8.86
GO Classification
Functions
    chloride channel activity
    GABA-A receptor activity
    extracellular ligand-gated ion channel activity
Processes
    chloride transmembrane transport
    regulation of membrane potential
    gamma-aminobutyric acid signaling pathway
    neurological system process
    synaptic transmission
    transmembrane transport
    transport
    ion transmembrane transport
Components
    neuron projection
    postsynaptic membrane
    plasma membrane
    chloride channel complex
    GABA-A receptor complex
    cell junction
    integral component of plasma membrane
    synapse
General FunctionGaba-a receptor activity
Specific FunctionGABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel. Rho-1 GABA receptor could play a role in retinal neurotransmission.
Transmembrane Regions282-305 309-331 343-365 458-479
GenBank Protein ID182911
UniProtKB IDP24046
UniProtKB Entry NameGBRR1_HUMAN
Cellular LocationCell junction
Gene sequence
>lcl|BSEQ0016019|Gamma-aminobutyric acid receptor subunit rho-1 (GABRR1)
ATGTTGGCTGTCCCAAATATGAGATTTGGCATCTTTCTTTTGTGGTGGGGATGGGTTTTG
GCCACTGAAAGCAGAATGCACTGGCCCGGAAGAGAAGTCCACGAGATGTCTAAGAAAGGC
AGCCCAATTCTGAGACGAAGTCCTGACATCACCAAATCGCCTCTGACAAAGTCAGAACAG
CTTCTGAGGATAGATGACCATGATTTCAGCATGAGGCCTGGCTTTGGAGGCCCTGCCATT
CCTGTTGGTGTGGATGTGCAGGTGGAGAGTTTGGATAGCATCTCAGAGGTTGACATGGAC
TTTACGATGACCCTCTACCTGAGGCACTACTGGAAGGACGAGAGGCTGTCTTTTCCAAGC
ACCAACAACCTCAGCATGACGTTTGACGGCCGGCTGGTCAAGAAGATCTGGGTCCCTGAC
ATGTTTTTCGTGCACTCCAAACGCTCCTTCATCCACGACACCACCACAGACAACGTCATG
TTGCGGGTCCAGCCTGATGGGAAAGTGCTCTATAGTCTCAGGGTTACAGTAACTGCAATG
TGCAACATGGACTTCAGCCGATTTCCCTTGGACACACAAACGTGCTCTCTTGAAATTGAA
AGCTATGCCTATACAGAAGATGACCTCATGCTGTACTGGAAAAAGGGCAATGACTCCTTA
AAGACAGATGAACGGATCTCACTCTCCCAGTTCCTCATTCAGGAATTCCACACCACCACC
AAACTGGCTTTCTACAGCAGCACAGGCTGGTACAACCGTCTCTACATTAATTTCACGTTG
CGTCGCCACATCTTCTTCTTCTTGCTCCAAACTTATTTCCCCGCTACCCTGATGGTCATG
CTGTCCTGGGTGTCCTTCTGGATCGACCGCAGAGCCGTGCCTGCCAGAGTCCCCTTAGGT
ATCACAACGGTGCTGACCATGTCCACCATCATCACGGGCGTGAATGCCTCCATGCCGCGC
GTCTCCTACATCAAGGCCGTGGACATCTACCTCTGGGTCAGCTTTGTGTTCGTGTTCCTC
TCGGTGCTGGAGTATGCGGCCGTCAACTACCTGACCACTGTGCAGGAGAGGAAGGAACAG
AAGCTGCGGGAGAAGCTTCCCTGCACCAGCGGATTACCTCCGCCCCGCACTGCGATGCTG
GACGGCAACTACAGTGATGGGGAGGTGAATGACCTGGACAACTACATGCCAGAGAATGGA
GAGAAGCCCGACAGGATGATGGTGCAGCTGACCCTGGCCTCAGAGAGGAGCTCCCCACAG
AGGAAAAGTCAGAGAAGCAGCTATGTGAGCATGAGAATCGACACCCACGCCATTGATAAA
TACTCCAGGATCATCTTTCCAGCAGCATACATTTTATTCAATTTAATATACTGGTCTATT
TTCTCCTAG
GenBank Gene IDM62400
GeneCard IDNone
GenAtlas IDGABRR1
HGNC IDHGNC:4090
Chromosome Location6
Locus6q14-q21|6q13-q16.3
References
  1. Cutting GR, Lu L, O'Hara BF, Kasch LM, Montrose-Rafizadeh C, Donovan DM, Shimada S, Antonarakis SE, Guggino WB, Uhl GR, et al.: Cloning of the gamma-aminobutyric acid (GABA) rho 1 cDNA: a GABA receptor subunit highly expressed in the retina. Proc Natl Acad Sci U S A. 1991 Apr 1;88(7):2673-7.[1849271 ]
  2. Mungall AJ, Palmer SA, Sims SK, Edwards CA, Ashurst JL, Wilming L, Jones MC, Horton R, Hunt SE, Scott CE, Gilbert JG, Clamp ME, Bethel G, Milne S, Ainscough R, Almeida JP, Ambrose KD, Andrews TD, Ashwell RI, Babbage AK, Bagguley CL, Bailey J, Banerjee R, Barker DJ, Barlow KF, Bates K, Beare DM, Beasley H, Beasley O, Bird CP, Blakey S, Bray-Allen S, Brook J, Brown AJ, Brown JY, Burford DC, Burrill W, Burton J, Carder C, Carter NP, Chapman JC, Clark SY, Clark G, Clee CM, Clegg S, Cobley V, Collier RE, Collins JE, Colman LK, Corby NR, Coville GJ, Culley KM, Dhami P, Davies J, Dunn M, Earthrowl ME, Ellington AE, Evans KA, Faulkner L, Francis MD, Frankish A, Frankland J, French L, Garner P, Garnett J, Ghori MJ, Gilby LM, Gillson CJ, Glithero RJ, Grafham DV, Grant M, Gribble S, Griffiths C, Griffiths M, Hall R, Halls KS, Hammond S, Harley JL, Hart EA, Heath PD, Heathcott R, Holmes SJ, Howden PJ, Howe KL, Howell GR, Huckle E, Humphray SJ, Humphries MD, Hunt AR, Johnson CM, Joy AA, Kay M, Keenan SJ, Kimberley AM, King A, Laird GK, Langford C, Lawlor S, Leongamornlert DA, Leversha M, Lloyd CR, Lloyd DM, Loveland JE, Lovell J, Martin S, Mashreghi-Mohammadi M, Maslen GL, Matthews L, McCann OT, McLaren SJ, McLay K, McMurray A, Moore MJ, Mullikin JC, Niblett D, Nickerson T, Novik KL, Oliver K, Overton-Larty EK, Parker A, Patel R, Pearce AV, Peck AI, Phillimore B, Phillips S, Plumb RW, Porter KM, Ramsey Y, Ranby SA, Rice CM, Ross MT, Searle SM, Sehra HK, Sheridan E, Skuce CD, Smith S, Smith M, Spraggon L, Squares SL, Steward CA, Sycamore N, Tamlyn-Hall G, Tester J, Theaker AJ, Thomas DW, Thorpe A, Tracey A, Tromans A, Tubby B, Wall M, Wallis JM, West AP, White SS, Whitehead SL, Whittaker H, Wild A, Willey DJ, Wilmer TE, Wood JM, Wray PW, Wyatt JC, Young L, Younger RM, Bentley DR, Coulson A, Durbin R, Hubbard T, Sulston JE, Dunham I, Rogers J, Beck S: The DNA sequence and analysis of human chromosome 6. Nature. 2003 Oct 23;425(6960):805-11.[14574404 ]
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Related FRC


FRCD ID Name Exact Mass Structure



Methiochlor




377.766



Chlorbenzylate




325.185



1,3,5-Trichlorobenzene




181.44



Mirex




545.51



Isodrin




364.896



Diazepam




284.74



Anisatin




328.317



Oenanthotoxin




258.361



Aflatrem




501.667



Penitrem A




634.21



Penitrem B




583.769



Penitrem C




602.212



Fumitremorgin C




379.46



Paspalinine




433.548



Janthitrem B




585.785



Janthitrem C




569.786



Janthitrem E




603.8



Janthitrem F




645.837



Janthitrem G




629.838



Paspalitrem A




501.667



Paspalicine




417.549



Paxilline




435.564



Verrucosidin




416.514



Verruculogen




511.575



Lormetazepam




335.184



Toxaphene




411.774



Hexachlorobutadiene




260.744



Heptachlor




373.3



Chlorobenzene




112.556



1,2,3-Trichlorobenzene




181.44



Telodrin




411.73



Cicutoxin




258.361



Fumitremorgin A




579.694



Fumitremorgin B




479.577



Chloroform




119.369



Clofenotane




354.476



Trichloroethylene




131.38



Dieldrin




380.895



Chlordane




409.758



Tetrachloroethylene




165.822



3,3'-Dichlorobenzidine




253.126



Endrin




380.895



Pentachlorophenol




266.323



Toluene




92.141



1,1-Dichloroethene




96.938



1,2-Dichloroethane




98.954



2,4,6-Trichlorophenol




197.439



Hexachlorobenzene




284.766



1,1,1-Trichloroethane




133.396



Chlorpyrifos




350.575



Chlordecone




490.609



Dicofol




370.475



1,1,2,2-Tetrachloroethane




167.838



1,4-Dichlorobenzene




146.998



1,1-Dichloroethane




98.954



Hexachlorocyclopentadiene




272.755



1,2-Dichlorobenzene




146.998



1,2,4-Trichlorobenzene




181.44