C-X-C chemokine receptor type 1
Name | C-X-C chemokine receptor type 1 |
---|---|
Synonyms | CDw128a CMKAR1 CXC-R1 High affinity interleukin-8 receptor A IL-8 receptor type 1 IL-8R A IL8RA |
Gene Name | CXCR1 |
Organism | Human |
Amino acid sequence | >lcl|BSEQ0012470|C-X-C chemokine receptor type 1 MSNITDPQMWDFDDLNFTGMPPADEDYSPCMLETETLNKYVVIIAYALVFLLSLLGNSLV MLVILYSRVGRSVTDVYLLNLALADLLFALTLPIWAASKVNGWIFGTFLCKVVSLLKEVN FYSGILLLACISVDRYLAIVHATRTLTQKRHLVKFVCLGCWGLSMNLSLPFFLFRQAYHP NNSSPVCYEVLGNDTAKWRMVLRILPHTFGFIVPLFVMLFCYGFTLRTLFKAHMGQKHRA MRVIFAVVLIFLLCWLPYNLVLLADTLMRTQVIQESCERRNNIGRALDATEILGFLHSCL NPIIYAFIGQNFRHGFLKILAMHGLVSKEFLARHRVTSYTSSSVNVSSNL |
Number of residues | 350 |
Molecular Weight | 39790.735 |
Theoretical pI | 8.81 |
GO Classification |
Functions
G-protein coupled receptor activity chemokine receptor activity interleukin-8 binding interleukin-8 receptor activity Processes
cell surface receptor signaling pathway chemokine-mediated signaling pathway dendritic cell chemotaxis interleukin-8-mediated signaling pathway inflammatory response chemotaxis receptor internalization G-protein coupled receptor signaling pathway Components
membrane plasma membrane integral component of membrane |
General Function | Interleukin-8 receptor activity |
Specific Function | Receptor to interleukin-8, which is a powerful neutrophils chemotactic factor. Binding of IL-8 to the receptor causes activation of neutrophils. This response is mediated via a G-protein that activate a phosphatidylinositol-calcium second messenger system. This receptor binds to IL-8 with a high affinity and to MGSA (GRO) with a low affinity. |
Transmembrane Regions | 40-66 76-96 112-133 155-174 200-220 243-264 286-308 |
GenBank Protein ID | 559050 |
UniProtKB ID | P25024 |
UniProtKB Entry Name | CXCR1_HUMAN |
Cellular Location | Cell membrane |
Gene sequence | >lcl|BSEQ0012471|C-X-C chemokine receptor type 1 (CXCR1) ATGTCAAATATTACAGATCCACAGATGTGGGATTTTGATGATCTAAATTTCACTGGCATG CCACCTGCAGATGAAGATTACAGCCCCTGTATGCTAGAAACTGAGACACTCAACAAGTAT GTTGTGATCATCGCCTATGCCCTAGTGTTCCTGCTGAGCCTGCTGGGAAACTCCCTGGTG ATGCTGGTCATCTTATACAGCAGGGTCGGCCGCTCCGTCACTGATGTCTACCTGCTGAAC CTGGCCTTGGCCGACCTACTCTTTGCCCTGACCTTGCCCATCTGGGCCGCCTCCAAGGTG AATGGCTGGATTTTTGGCACATTCCTGTGCAAGGTGGTCTCACTCCTGAAGGAAGTCAAC TTCTACAGTGGCATCCTGCTGTTGGCCTGCATCAGTGTGGACCGTTACCTGGCCATTGTC CATGCCACACGCACACTGACCCAGAAGCGTCACTTGGTCAAGTTTGTTTGTCTTGGCTGC TGGGGACTGTCTATGAATCTGTCCCTGCCCTTCTTCCTTTTCCGCCAGGCTTACCATCCA AACAATTCCAGTCCAGTTTGCTATGAGGTCCTGGGAAATGACACAGCAAAATGGCGGATG GTGTTGCGGATCCTGCCTCACACCTTTGGCTTCATCGTGCCGCTGTTTGTCATGCTGTTC TGCTATGGATTCACCCTGCGTACACTGTTTAAGGCCCACATGGGGCAGAAGCACCGAGCC ATGAGGGTCATCTTTGCTGTCGTCCTCATCTTCCTGCTTTGCTGGCTGCCCTACAACCTG GTCCTGCTGGCAGACACCCTCATGAGGACCCAGGTGATCCAGGAGAGCTGTGAGCGCCGC AACAACATCGGCCGGGCCCTGGATGCCACTGAGATTCTGGGATTTCTCCATAGCTGCCTC AACCCCATCATCTACGCCTTCATCGGCCAAAATTTTCGCCATGGATTCCTCAAGATCCTG GCTATGCATGGCCTGGTCAGCAAGGAGTTCTTGGCACGTCATCGTGTTACCTCCTACACT TCTTCGTCTGTCAATGTCTCTTCCAACCTCTGA |
GenBank Gene ID | L19591 |
GeneCard ID | None |
GenAtlas ID | |
HGNC ID | HGNC:6026 |
Chromosome Location | 2 |
Locus | None |
References |
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Related FRC
FRCD ID | Name | Exact Mass | Structure |
---|---|---|---|
Clotrimazole |
344.842 |