Tumor necrosis factor receptor superfamily member 5
Name | Tumor necrosis factor receptor superfamily member 5 |
---|---|
Synonyms | B-cell surface antigen CD40 Bp50 CD40L receptor CDw40 TNFRSF5 |
Gene Name | CD40 |
Organism | Human |
Amino acid sequence | >lcl|BSEQ0002379|Tumor necrosis factor receptor superfamily member 5 MVRLPLQCVLWGCLLTAVHPEPPTACREKQYLINSQCCSLCQPGQKLVSDCTEFTETECL PCGESEFLDTWNRETHCHQHKYCDPNLGLRVQQKGTSETDTICTCEEGWHCTSEACESCV LHRSCSPGFGVKQIATGVSDTICEPCPVGFFSNVSSAFEKCHPWTSCETKDLVVQQAGTN KTDVVCGPQDRLRALVVIPIIFGILFAILLVLVFIKKVAKKPTNKAPHPKQEPQEINFPD DLPGSNTAAPVQETLHGCQPVTQEDGKESRISVQERQ |
Number of residues | 277 |
Molecular Weight | 30618.76 |
Theoretical pI | 5.57 |
GO Classification |
Functions
signal transducer activity receptor activity ubiquitin protein ligase binding enzyme binding antigen binding tumor necrosis factor-activated receptor activity Processes
positive regulation of endothelial cell apoptotic process response to lipopolysaccharide positive regulation of I-kappaB kinase/NF-kappaB signaling regulation of immunoglobulin secretion positive regulation of protein phosphorylation positive regulation of GTPase activity positive regulation of NF-kappaB transcription factor activity immune response-regulating cell surface receptor signaling pathway regulation of cell proliferation protein kinase B signaling positive regulation of B cell proliferation cellular response to lipopolysaccharide defense response to virus defense response to protozoan cellular response to mechanical stimulus cellular calcium ion homeostasis inflammatory response positive regulation of isotype switching to IgG isotypes regulation of immune response positive regulation of MAP kinase activity positive regulation of tyrosine phosphorylation of Stat1 protein apoptotic signaling pathway platelet activation positive regulation of transcription from RNA polymerase II promoter positive regulation of protein kinase C signaling multicellular organismal development tumor necrosis factor-mediated signaling pathway protein complex assembly B cell proliferation positive regulation of interleukin-12 production Components
extracellular exosome cytoplasm external side of plasma membrane plasma membrane integral component of plasma membrane extracellular space cell surface intracellular membrane-bounded organelle CD40 receptor complex |
General Function | Ubiquitin protein ligase binding |
Specific Function | Receptor for TNFSF5/CD40LG. Transduces TRAF6- and MAP3K8-mediated signals that activate ERK in macrophages and B cells, leading to induction of immunoglobulin secretion. |
Transmembrane Regions | 194-215 |
GenBank Protein ID | 29851 |
UniProtKB ID | P25942 |
UniProtKB Entry Name | TNR5_HUMAN |
Cellular Location | Cell membrane |
Gene sequence | >lcl|BSEQ0016348|Tumor necrosis factor receptor superfamily member 5 (CD40) ATGGTTCGTCTGCCTCTGCAGTGCGTCCTCTGGGGCTGCTTGCTGACCGCTGTCCATCCA GAACCACCCACTGCATGCAGAGAAAAACAGTACCTAATAAACAGTCAGTGCTGTTCTTTG TGCCAGCCAGGACAGAAACTGGTGAGTGACTGCACAGAGTTCACTGAAACGGAATGCCTT CCTTGCGGTGAAAGCGAATTCCTAGACACCTGGAACAGAGAGACACACTGCCACCAGCAC AAATACTGCGACCCCAACCTAGGGCTTCGGGTCCAGCAGAAGGGCACCTCAGAAACAGAC ACCATCTGCACCTGTGAAGAAGGCTGGCACTGTACGAGTGAGGCCTGTGAGAGCTGTGTC CTGCACCGCTCATGCTCGCCCGGCTTTGGGGTCAAGCAGATTGCTACAGGGGTTTCTGAT ACCATCTGCGAGCCCTGCCCAGTCGGCTTCTTCTCCAATGTGTCATCTGCTTTCGAAAAA TGTCACCCTTGGACAAGCTGTGAGACCAAAGACCTGGTTGTGCAACAGGCAGGCACAAAC AAGACTGATGTTGTCTGTGGTCCCCAGGATCGGCTGAGAGCCCTGGTGGTGATCCCCATC ATCTTCGGGATCCTGTTTGCCATCCTCTTGGTGCTGGTCTTTATCAAAAAGGTGGCCAAG AAGCCAACCAATAAGGCCCCCCACCCCAAGCAGGAACCCCAGGAGATCAATTTTCCCGAC GATCTTCCTGGCTCCAACACTGCTGCTCCAGTGCAGGAGACTTTACATGGATGCCAACCG GTCACCCAGGAGGATGGCAAAGAGAGTCGCATCTCAGTGCAGGAGAGACAGTGA |
GenBank Gene ID | X60592 |
GeneCard ID | None |
GenAtlas ID | CD40 |
HGNC ID | HGNC:11919 |
Chromosome Location | 20 |
Locus | 20q12-q13.2 |
References |
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