Adenylate kinase 4, mitochondrial


NameAdenylate kinase 4, mitochondrial
Synonyms2.7.4.10 Adenylate kinase 3-like AK 4 AK3 AK3L1 GTP:AMP phosphotransferase AK4
Gene NameAK4
OrganismHuman
Amino acid sequence
>lcl|BSEQ0013314|Adenylate kinase 4, mitochondrial
MASKLLRAVILGPPGSGKGTVCQRIAQNFGLQHLSSGHFLRENIKASTEVGEMAKQYIEK
SLLVPDHVITRLMMSELENRRGQHWLLDGFPRTLGQAEALDKICEVDLVISLNIPFETLK
DRLSRRWIHPPSGRVYNLDFNPPHVHGIDDVTGEPLVQQEDDKPEAVAARLRQYKDVAKP
VIELYKSRGVLHQFSGTETNKIWPYVYTLFSNKITPIQSKEAY
Number of residues223
Molecular Weight25267.83
Theoretical pINone
GO Classification
Functions
    ATP binding
    GTP binding
    nucleoside triphosphate adenylate kinase activity
    adenylate kinase activity
    nucleoside diphosphate kinase activity
Processes
    brain development
    liver development
    ATP metabolic process
    nucleoside diphosphate phosphorylation
    nucleoside triphosphate biosynthetic process
    AMP metabolic process
    response to drug
    GTP metabolic process
    ADP biosynthetic process
Components
    mitochondrion
    mitochondrial matrix
    extracellular exosome
General FunctionNucleoside triphosphate adenylate kinase activity
Specific FunctionInvolved in maintaining the homeostasis of cellular nucleotides by catalyzing the interconversion of nucleoside phosphates. Efficiently phosphorylates AMP and dAMP using ATP as phosphate donor, but phosphorylates only AMP when using GTP as phosphate donor. Also displays broad nucleoside diphosphate kinase activity.
Transmembrane Regions
GenBank Protein ID
UniProtKB IDP27144
UniProtKB Entry NameKAD4_HUMAN
Cellular LocationMitochondrion matrix
Gene sequence
>lcl|BSEQ0013315|Adenylate kinase 4, mitochondrial (AK4)
ATGGCTTCCAAACTCCTGCGCGCGGTCATCCTCGGGCCGCCCGGCTCGGGCAAGGGCACC
GTGTGCCAGAGGATCGCCCAGAACTTTGGTCTCCAGCATCTCTCCAGCGGCCACTTCTTG
CGGGAGAACATCAAGGCCAGCACCGAAGTTGGTGAGATGGCAAAGCAGTATATAGAGAAA
AGTCTTTTGGTTCCAGACCATGTGATCACACGCCTAATGATGTCCGAGTTGGAGAACAGG
CGTGGCCAGCACTGGCTCCTTGATGGTTTTCCTAGGACATTAGGACAAGCCGAAGCCCTG
GACAAAATCTGTGAAGTGGATCTAGTGATCAGTTTGAATATTCCATTTGAAACACTTAAA
GATCGTCTCAGCCGCCGTTGGATTCACCCTCCTAGCGGAAGGGTATATAACCTGGACTTC
AATCCACCTCATGTACATGGTATTGATGACGTCACTGGTGAACCGTTAGTCCAGCAGGAG
GATGATAAACCCGAAGCAGTTGCTGCCAGGCTAAGACAGTACAAAGACGTGGCAAAGCCA
GTCATTGAATTATACAAGAGCCGAGGAGTGCTCCACCAATTTTCCGGAACGGAGACGAAC
AAAATCTGGCCCTACGTTTACACACTTTTCTCAAACAAGATCACACCTATTCAGTCCAAA
GAAGCATATTGA
GenBank Gene ID
GeneCard IDNone
GenAtlas ID
HGNC IDHGNC:363
Chromosome Location1
LocusNone
References
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  4. Noma T, Fujisawa K, Yamashiro Y, Shinohara M, Nakazawa A, Gondo T, Ishihara T, Yoshinobu K: Structure and expression of human mitochondrial adenylate kinase targeted to the mitochondrial matrix. Biochem J. 2001 Aug 15;358(Pt 1):225-32.[11485571 ]
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  9. Liu R, Xu H, Wei Z, Wang Y, Lin Y, Gong W: Crystal structure of human adenylate kinase 4 (L171P) suggests the role of hinge region in protein domain motion. Biochem Biophys Res Commun. 2009 Jan 30;379(1):92-7. doi: 10.1016/j.bbrc.2008.12.012. Epub 2008 Dec 13.[19073142 ]
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