Proteasome subunit beta type-5


NameProteasome subunit beta type-5
Synonyms3.4.25.1 LMPX Macropain epsilon chain MB1 Multicatalytic endopeptidase complex epsilon chain Proteasome chain 6 Proteasome epsilon chain Proteasome subunit MB1 Proteasome subunit X X
Gene NamePSMB5
OrganismHuman
Amino acid sequence
>lcl|BSEQ0037858|Proteasome subunit beta type-5
MALASVLERPLPVNQRGFFGLGGRADLLDLGPGSLSDGLSLAAPGWGVPEEPGIEMLHGT
TTLAFKFRHGVIVAADSRATAGAYIASQTVKKVIEINPYLLGTMAGGAADCSFWERLLAR
QCRIYELRNKERISVAAASKLLANMVYQYKGMGLSMGTMICGWDKRGPGLYYVDSEGNRI
SGATFSVGSGSVYAYGVMDRGYSYDLEVEQAYDLARRAIYQATYRDAYSGGAVNLYHVRE
DGWIRVSSDNVADLHEKYSGSTP
Number of residues263
Molecular Weight28480.01
Theoretical pI8.68
GO Classification
Functions
    threonine-type endopeptidase activity
    endopeptidase activity
Processes
    stimulatory C-type lectin receptor signaling pathway
    small GTPase mediated signal transduction
    antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent
    Fc-epsilon receptor signaling pathway
    tumor necrosis factor-mediated signaling pathway
    vascular endothelial growth factor receptor signaling pathway
    cellular nitrogen compound metabolic process
    antigen processing and presentation of peptide antigen via MHC class I
    positive regulation of canonical Wnt signaling pathway
    antigen processing and presentation of exogenous peptide antigen via MHC class I
    gene expression
    DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
    activation of MAPKK activity
    polyamine metabolic process
    regulation of apoptotic process
    negative regulation of canonical Wnt signaling pathway
    apoptotic process
    mitotic cell cycle
    small molecule metabolic process
    negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
    fibroblast growth factor receptor signaling pathway
    proteasomal ubiquitin-independent protein catabolic process
    G1/S transition of mitotic cell cycle
    NIK/NF-kappaB signaling
    insulin receptor signaling pathway
    T cell receptor signaling pathway
    positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition
    MAPK cascade
    regulation of cellular amino acid metabolic process
    proteasome-mediated ubiquitin-dependent protein catabolic process
    negative regulation of apoptotic process
    viral process
    protein polyubiquitination
    axon guidance
    neurotrophin TRK receptor signaling pathway
    programmed cell death
    regulation of mRNA stability
    epidermal growth factor receptor signaling pathway
    Ras protein signal transduction
    response to oxidative stress
    anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process
    innate immune response
    regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
Components
    centrosome
    proteasome core complex
    cytosol
    cytoplasm
    extracellular exosome
    nucleoplasm
    nucleus
    proteasome complex
General FunctionThreonine-type endopeptidase activity
Specific FunctionThe proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity. This unit is responsible of the chymotrypsin-like activity of the proteasome and is one of the principal target of the proteasome inhibitor bortezomib. May catalyze basal processing of intracellular antigens. Plays a role in the protection against oxidative damage through the Nrf2-ARE pathway (By similarity).
Transmembrane Regions
GenBank Protein ID558526
UniProtKB IDP28074
UniProtKB Entry NamePSB5_HUMAN
Cellular LocationCytoplasm
Gene sequence
>lcl|BSEQ0019273|Proteasome subunit beta type-5 (PSMB5)
ATGGCTGGGGGCGCAGCGGATTGCAGCTTCTGGGAACGGCTGTTGGCTCGGCAATGTCGA
ATCTATGAGCTTCGAAATAAGGAACGCATCTCTGTAGCAGCTGCCTCCAAACTGCTTGCC
AACATGGTGTATCAGTACAAAGGCATGGGGCTGTCCATGGGCACCATGATCTGTGGCTGG
GATAAGAGAGGCCCTGGCCTCTACTACGTGGACAGTGAAGGGAACCGGATTTCAGGGGCC
ACCTTCTCTGTAGGTTCTGGCTCTGTGTATGCATATGGGGTCATGGATCGGGGCTATTCC
TATGACCTGGAAGTGGAGCAGGCCTATGATCTGGCCCGTCGAGCCATCTACCAAGCCACC
TACAGAGATGCCTACTCAGGAGGTGCAGTCAACCTCTACCACGTGCGGGAGGATGGCTGG
ATCCGAGTCTCCAGTGACAATGTGGCTGATCTACATGAGAAGTATAGTGGCTCTACCCCC
TGA
GenBank Gene IDD29011
GeneCard IDNone
GenAtlas IDPSMB5
HGNC IDHGNC:9542
Chromosome Location14
Locus14q11.2
References
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