Glutathione S-transferase Mu 2


NameGlutathione S-transferase Mu 2
Synonyms2.5.1.18 GST class-mu 2 GST4 GSTM2-2
Gene NameGSTM2
OrganismHuman
Amino acid sequence
>lcl|BSEQ0002365|Glutathione S-transferase Mu 2
MPMTLGYWNIRGLAHSIRLLLEYTDSSYEEKKYTMGDAPDYDRSQWLNEKFKLGLDFPNL
PYLIDGTHKITQSNAILRYIARKHNLCGESEKEQIREDILENQFMDSRMQLAKLCYDPDF
EKLKPEYLQALPEMLKLYSQFLGKQPWFLGDKITFVDFIAYDVLERNQVFEPSCLDAFPN
LKDFISRFEGLEKISAYMKSSRFLPRPVFTKMAVWGNK
Number of residues218
Molecular Weight25744.395
Theoretical pI6.29
GO Classification
Functions
    protein homodimerization activity
    receptor binding
    glutathione transferase activity
    glutathione binding
    enzyme binding
Processes
    xenobiotic catabolic process
    regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
    negative regulation of ryanodine-sensitive calcium-release channel activity
    xenobiotic metabolic process
    regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
    relaxation of cardiac muscle
    cellular response to caffeine
    positive regulation of ryanodine-sensitive calcium-release channel activity
    glutathione metabolic process
    regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion
    glutathione derivative biosynthetic process
    cellular detoxification of nitrogen compound
    small molecule metabolic process
    nitrobenzene metabolic process
Components
    cytosol
    extracellular exosome
    sarcoplasmic reticulum
    cytoplasm
General FunctionReceptor binding
Specific FunctionConjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles.
Transmembrane Regions
GenBank Protein ID183301
UniProtKB IDP28161
UniProtKB Entry NameGSTM2_HUMAN
Cellular LocationCytoplasm
Gene sequence
>lcl|BSEQ0016345|Glutathione S-transferase Mu 2 (GSTM2)
ATGCCCATGACACTGGGGTACTGGAACATCCGCGGGCTGGCCCATTCCATCCGCCTGCTC
CTGGAATACACAGACTCAAGCTACGAGGAAAAGAAGTACACGATGGGGGACGCTCCTGAT
TATGACAGAAGCCAGTGGCTGAATGAAAAATTCAAGCTGGGCCTGGACTTTCCCAATCTG
CCCTACTTGATTGATGGGACTCACAAGATCACCCAGAGCAACGCCATCCTGCGGTACATT
GCCCGCAAGCACAACCTGTGCGGGGAATCAGAAAAGGAGCAGATTCGCGAAGACATTTTG
GAGAACCAGTTTATGGACAGCCGTATGCAGCTGGCCAAACTCTGCTATGACCCAGATTTT
GAGAAACTGAAACCAGAATACCTGCAGGCACTCCCTGAAATGCTGAAGCTCTACTCACAG
TTTCTGGGGAAGCAGCCATGGTTTCTTGGGGACAAGATCACCTTTGTGGATTTCATCGCT
TATGATGTCCTTGAGAGAAACCAAGTATTTGAGCCCAGCTGCCTGGATGCCTTCCCAAAC
CTGAAGGACTTCATCTCCCGATTTGAGGGCTTGGAGAAGATCTCTGCCTACATGAAGTCC
AGCCGCTTCCTCCCAAGACCTGTGTTCACAAAGATGGCTGTCTGGGGCAACAAGTAG
GenBank Gene IDM63509
GeneCard IDNone
GenAtlas IDGSTM2
HGNC IDHGNC:4634
Chromosome Location1
Locus1p13.3
References
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