5-hydroxytryptamine receptor 1B
Name | 5-hydroxytryptamine receptor 1B |
---|---|
Synonyms | 5-HT-1B 5-HT-1D-beta HTR1DB S12 Serotonin 1D beta receptor Serotonin receptor 1B |
Gene Name | HTR1B |
Organism | Human |
Amino acid sequence | >lcl|BSEQ0019014|5-hydroxytryptamine receptor 1B MEEPGAQCAPPPPAGSETWVPQANLSSAPSQNCSAKDYIYQDSISLPWKVLLVMLLALIT LATTLSNAFVIATVYRTRKLHTPANYLIASLAVTDLLVSILVMPISTMYTVTGRWTLGQV VCDFWLSSDITCCTASILHLCVIALDRYWAITDAVEYSAKRTPKRAAVMIALVWVFSISI SLPPFFWRQAKAEEEVSECVVNTDHILYTVYSTVGAFYFPTLLLIALYGRIYVEARSRIL KQTPNRTGKRLTRAQLITDSPGSTSSVTSINSRVPDVPSESGSPVYVNQVKVRVSDALLE KKKLMAARERKATKTLGIILGAFIVCWLPFFIISLVMPICKDACWFHLAIFDFFTWLGYL NSLINPIIYTMSNEDFKQAFHKLIRFKCTS |
Number of residues | 390 |
Molecular Weight | 43567.535 |
Theoretical pI | 8.82 |
GO Classification |
Functions
serotonin receptor activity drug binding serotonin binding Processes
protein kinase C-activating G-protein coupled receptor signaling pathway negative regulation of cAMP biosynthetic process vasoconstriction G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger regulation of behavior negative regulation of synaptic transmission, GABAergic regulation of dopamine secretion bone remodeling G-protein coupled receptor internalization response to cocaine cellular response to alkaloid cellular response to drug cellular response to temperature stimulus response to ethanol negative regulation of serotonin secretion drinking behavior adenylate cyclase-inhibiting serotonin receptor signaling pathway synaptic transmission negative regulation of synaptic transmission, glutamatergic response to mineralocorticoid Components
cytoplasm plasma membrane integral component of plasma membrane |
General Function | Serotonin receptor activity |
Specific Function | G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for ergot alkaloid derivatives, various anxiolytic and antidepressant drugs and other psychoactive substances, such as lysergic acid diethylamide (LSD). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity. Arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways. Regulates the release of 5-hydroxytryptamine, dopamine and acetylcholine in the brain, and thereby affects neural activity, nociceptive processing, pain perception, mood and behavior. Besides, plays a role in vasoconstriction of cerebral arteries. |
Transmembrane Regions | 50-75 85-110 124-145 166-187 206-228 316-336 350-371 |
GenBank Protein ID | 219679 |
UniProtKB ID | P28222 |
UniProtKB Entry Name | 5HT1B_HUMAN |
Cellular Location | Cell membrane |
Gene sequence | >lcl|BSEQ0019015|5-hydroxytryptamine receptor 1B (HTR1B) ATGGAGGAACCGGGTGCTCAGTGCGCTCCACCGCCGCCCGCGGGCTCCGAGACCTGGGTT CCTCAAGCCAACTTATCCTCTGCTCCCTCCCAAAACTGCAGCGCCAAGGACTACATTTAC CAGGACTCCATCTCCCTACCCTGGAAAGTACTGCTGGTTATGCTATTGGCGCTCATCACC TTGGCCACCACGCTCTCCAATGCCTTTGTGATTGCCACAGTGTACCGGACCCGGAAACTG CACACCCCGGCTAACTACCTGATCGCCTCTCTGGCGGTCACCGACCTGCTTGTGTCCATC CTGGTGATGCCCATCAGCACCATGTACACTGTCACCGGCCGCTGGACACTGGGCCAGGTG GTCTGTGACTTCTGGCTGTCGTCGGACATCACTTGTTGCACTGCCTCCATCCTGCACCTC TGTGTCATCGCCCTGGACCGCTACTGGGCCATCACGGACGCCGTGGAGTACTCAGCTAAA AGGACTCCCAAGAGGGCGGCGGTCATGATCGCGCTGGTGTGGGTCTTCTCCATCTCTATC TCGCTGCCGCCCTTCTTCTGGCGTCAGGCTAAGGCCGAAGAGGAGGTGTCGGAATGCGTG GTGAACACCGACCACATCCTCTACACGGTCTACTCCACGGTGGGTGCTTTCTACTTCCCC ACCCTGCTCCTCATCGCCCTCTATGGCCGCATCTACGTAGAAGCCCGCTCCCGGATTTTG AAACAGACGCCCAACAGGACCGGCAAGCGCTTGACCCGAGCCCAGCTGATAACCGACTCC CCCGGGTCCACGTCCTCGGTCACCTCTATTAACTCGCGGGTTCCCGACGTGCCCAGCGAA TCCGGATCTCCTGTGTATGTGAACCAAGTCAAAGTGCGAGTCTCCGACGCCCTGCTGGAA AAGAAGAAACTCATGGCCGCTAGGGAGCGCAAAGCCACCAAGACCCTAGGGATCATTTTG GGAGCCTTTATTGTGTGTTGGCTACCCTTCTTCATCATCTCCCTAGTGATGCCTATCTGC AAAGATGCCTGCTGGTTCCACCTAGCCATCTTTGACTTCTTCACATGGCTGGGCTATCTC AACTCCCTCATCAACCCCATAATCTATACCATGTCCAATGAGGACTTTAAACAAGCATTC CATAAACTGATACGTTTTAAGTGCACAAGTTGA |
GenBank Gene ID | D10995 |
GeneCard ID | None |
GenAtlas ID | HTR1B |
HGNC ID | HGNC:5287 |
Chromosome Location | 6 |
Locus | 6q13 |
References |
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