5-hydroxytryptamine receptor 2A
Name | 5-hydroxytryptamine receptor 2A |
---|---|
Synonyms | 5-HT-2 HTR2 Serotonin receptor 2A |
Gene Name | HTR2A |
Organism | Human |
Amino acid sequence | >lcl|BSEQ0000899|5-hydroxytryptamine receptor 2A MDILCEENTSLSSTTNSLMQLNDDTRLYSNDFNSGEANTSDAFNWTVDSENRTNLSCEGC LSPSCLSLLHLQEKNWSALLTAVVIILTIAGNILVIMAVSLEKKLQNATNYFLMSLAIAD MLLGFLVMPVSMLTILYGYRWPLPSKLCAVWIYLDVLFSTASIMHLCAISLDRYVAIQNP IHHSRFNSRTKAFLKIIAVWTISVGISMPIPVFGLQDDSKVFKEGSCLLADDNFVLIGSF VSFFIPLTIMVITYFLTIKSLQKEATLCVSDLGTRAKLASFSFLPQSSLSSEKLFQRSIH REPGSYTGRRTMQSISNEQKACKVLGIVFFLFVVMWCPFFITNIMAVICKESCNEDVIGA LLNVFVWIGYLSSAVNPLVYTLFNKTYRSAFSRYIQCQYKENKKPLQLILVNTIPALAYK SSQLQMGQKKNSKQDAKTTDNDCSMVALGKQHSEEASKDNSDGVNEKVSCV |
Number of residues | 471 |
Molecular Weight | 52602.58 |
Theoretical pI | 7.72 |
GO Classification |
Functions
virus receptor activity serotonin binding serotonin receptor activity drug binding 1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine binding Processes
positive regulation of cell proliferation regulation of behavior negative regulation of potassium ion transport sleep positive regulation of ERK1 and ERK2 cascade regulation of dopamine secretion regulation of hormone secretion serotonin receptor signaling pathway memory response to drug detection of mechanical stimulus involved in sensory perception of pain urinary bladder smooth muscle contraction aging cell death phosphatidylinositol 3-kinase signaling positive regulation of fat cell differentiation protein localization to cytoskeleton detection of temperature stimulus involved in sensory perception of pain artery smooth muscle contraction cellular calcium ion homeostasis negative regulation of synaptic transmission, glutamatergic synaptic transmission temperature homeostasis phospholipase C-activating serotonin receptor signaling pathway activation of phospholipase C activity positive regulation of peptidyl-tyrosine phosphorylation positive regulation of phosphatidylinositol biosynthetic process positive regulation of vasoconstriction positive regulation of glycolytic process release of sequestered calcium ion into cytosol positive regulation of MAP kinase activity behavioral response to cocaine Components
cell body fiber neuronal cell body dendritic shaft caveola plasma membrane cytoplasmic membrane-bounded vesicle cytosol axon integral component of plasma membrane |
General Function | Virus receptor activity |
Specific Function | G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various drugs and psychoactive substances, including mescaline, psilocybin, 1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane (DOI) and lysergic acid diethylamide (LSD). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Beta-arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways. Signaling activates phospholipase C and a phosphatidylinositol-calcium second messenger system that modulates the activity of phosphatidylinositol 3-kinase and promotes the release of Ca(2+) ions from intracellular stores. Affects neural activity, perception, cognition and mood. Plays a role in the regulation of behavior, including responses to anxiogenic situations and psychoactive substances. Plays a role in intestinal smooth muscle contraction, and may play a role in arterial vasoconstriction.(Microbial infection) Acts as a receptor for human JC polyomavirus/JCPyV. |
Transmembrane Regions | 76-99 111-132 149-171 192-215 234-254 325-346 363-384 |
GenBank Protein ID | 36431 |
UniProtKB ID | P28223 |
UniProtKB Entry Name | 5HT2A_HUMAN |
Cellular Location | Cell membrane |
Gene sequence | >lcl|BSEQ0020465|5-hydroxytryptamine receptor 2A (HTR2A) ATGGATATTCTTTGTGAAGAAAATACTTCTTTGAGCTCAACTACGAACTCCCTAATGCAA TTAAATGATGACACCAGGCTCTACAGTAATGACTTTAACTCCGGAGAAGCTAACACTTCT GATGCATTTAACTGGACAGTCGACTCTGAAAATCGAACCAACCTTTCCTGTGAAGGGTGC CTCTCACCGTCGTGTCTCTCCTTACTTCATCTCCAGGAAAAAAACTGGTCTGCTTTACTG ACAGCCGTAGTGATTATTCTAACTATTGCTGGAAACATACTCGTCATCATGGCAGTGTCC CTAGAGAAAAAGCTGCAGAATGCCACCAACTATTTCCTGATGTCACTTGCCATAGCTGAT ATGCTGCTGGGTTTCCTTGTCATGCCCGTGTCCATGTTAACCATCCTGTATGGGTACCGG TGGCCTCTGCCGAGCAAGCTTTGTGCAGTCTGGATTTACCTGGACGTGCTCTTCTCCACG GCCTCCATCATGCACCTCTGCGCCATCTCGCTGGACCGCTACGTCGCCATCCAGAATCCC ATCCACCACAGCCGCTTCAACTCCAGAACTAAGGCATTTCTGAAAATCATTGCTGTTTGG ACCATATCAGTAGGTATATCCATGCCAATACCAGTCTTTGGGCTACAGGACGATTCGAAG GTCTTTAAGGAGGGGAGTTGCTTACTCGCCGATGATAACTTTGTCCTGATCGGCTCTTTT GTGTCATTTTTCATTCCCTTAACCATCATGGTGATCACCTACTTTCTAACTATCAAGTCA CTCCAGAAAGAAGCTACTTTGTGTGTAAGTGATCTTGGCACACGGGCCAAATTAGCTTCT TTCAGCTTCCTCCCTCAGAGTTCTTTGTCTTCAGAAAAGCTCTTCCAGCGGTCGATCCAT AGGGAGCCAGGGTCCTACACAGGCAGGAGGACTATGCAGTCCATCAGCAATGAGCAAAAG GCATGCAAGGTGCTGGGCATCGTCTTCTTCCTGTTTGTGGTGATGTGGTGCCCTTTCTTC ATCACAAACATCATGGCCGTCATCTGCAAAGAGTCCTGCAATGAGGATGTCATTGGGGCC CTGCTCAATGTGTTTGTTTGGATCGGTTATCTCTCTTCAGCAGTCAACCCACTAGTCTAC ACACTGTTCAACAAGACCTATAGGTCAGCCTTTTCACGGTATATTCAGTGTCAGTACAAG GAAAACAAAAAACCATTGCAGTTAATTTTAGTGAACACAATACCGGCTTTGGCCTACAAG TCTAGCCAACTTCAAATGGGACAAAAAAAGAATTCAAAGCAAGATGCCAAGACAACAGAT AATGACTGCTCAATGGTTGCTCTAGGAAAGCAGCATTCTGAAGAGGCTTCTAAAGACAAT AGCGACGGAGTGAATGAAAAGGTGAGCTGTGTGTGA |
GenBank Gene ID | S42168 |
GeneCard ID | None |
GenAtlas ID | HTR2A |
HGNC ID | HGNC:5293 |
Chromosome Location | 13 |
Locus | 13q14-q21 |
References |
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