FRCD

Receptor-type tyrosine-protein phosphatase mu

Name	Receptor-type tyrosine-protein phosphatase mu
Synonyms	3.1.3.48 Protein-tyrosine phosphatase mu PTPRL1
Gene Name	PTPRM
Organism	Human
Amino acid sequence	>lcl\|BSEQ0009011\|Receptor-type tyrosine-protein phosphatase mu MRGLGTCLATLAGLLLTAAGETFSGGCLFDEPYSTCGYSQSEGDDFNWEQVNTLTKPTSD PWMPSGSFMLVNASGRPEGQRAHLLLPQLKENDTHCIDFHYFVSSKSNSPPGLLNVYVKV NNGPLGNPIWNISGDPTRTWNRAELAISTFWPNFYQVIFEVITSGHQGYLAIDEVKVLGH PCTRTPHFLRIQNVEVNAGQFATFQCSAIGRTVAGDRLWLQGIDVRDAPLKEIKVTSSRR FIASFNVVNTTKRDAGKYRCMIRTEGGVGISNYAELVVKEPPVPIAPPQLASVGATYLWI QLNANSINGDGPIVAREVEYCTASGSWNDRQPVDSTSYKIGHLDPDTEYEISVLLTRPGE GGTGSPGPALRTRTKCADPMRGPRKLEVVEVKSRQITIRWEPFGYNVTRCHSYNLTVHYC YQVGGQEQVREEVSWDTENSHPQHTITNLSPYTNVSVKLILMNPEGRKESQELIVQTDED LPGAVPTESIQGSTFEEKIFLQWREPTQTYGVITLYEITYKAVSSFDPEIDLSNQSGRVS KLGNETHFLFFGLYPGTTYSFTIRASTAKGFGPPATNQFTTKISAPSMPAYELETPLNQT DNTVTVMLKPAHSRGAPVSVYQIVVEEERPRRTKKTTEILKCYPVPIHFQNASLLNSQYY FAAEFPADSLQAAQPFTIGDNKTYNGYWNTPLLPYKSYRIYFQAASRANGETKIDCVQVA TKGAATPKPVPEPEKQTDHTVKIAGVIAGILLFVIIFLGVVLVMKKRKLAKKRKETMSST RQEMTVMVNSMDKSYAEQGTNCDEAFSFMDTHNLNGRSVSSPSSFTMKTNTLSTSVPNSY YPDETHTMASDTSSLVQSHTYKKREPADVPYQTGQLHPAIRVADLLQHITQMKCAEGYGF KEEYESFFEGQSAPWDSAKKDENRMKNRYGNIIAYDHSRVRLQTIEGDTNSDYINGNYID GYHRPNHYIATQGPMQETIYDFWRMVWHENTASIIMVTNLVEVGRVKCCKYWPDDTEIYK DIKVTLIETELLAEYVIRTFAVEKRGVHEIREIRQFHFTGWPDHGVPYHATGLLGFVRQV KSKSPPSAGPLVVHCSAGAGRTGCFIVIDIMLDMAEREGVVDIYNCVRELRSRRVNMVQT EEQYVFIHDAILEACLCGDTSVPASQVRSLYYDMNKLDPQTNSSQIKEEFRTLNMVTPTL RVEDCSIALLPRNHEKNRCMDILPPDRCLPFLITIDGESSNYINAALMDSYKQPSAFIVT QHPLPNTVKDFWRLVLDYHCTSVVMLNDVDPAQLCPQYWPENGVHRHGPIQVEFVSADLE EDIISRIFRIYNAARPQDGYRMVQQFQFLGWPMYRDTPVSKRSFLKLIRQVDKWQEEYNG GEGRTVVHCLNGGGRSGTFCAISIVCEMLRHQRTVDVFHAVKTLRNNKPNMVDLLDQYKF CYEVALEYLNSG
Number of residues	1452
Molecular Weight	163681.285
Theoretical pI	None
GO Classification	Functions transmembrane receptor protein tyrosine phosphatase activity protein tyrosine phosphatase activity identical protein binding cadherin binding Processes protein dephosphorylation retina layer formation homophilic cell adhesion via plasma membrane adhesion molecules retinal ganglion cell axon guidance positive regulation of vasodilation signal transduction negative regulation of endothelial cell migration response to drug negative regulation of endothelial cell proliferation peptidyl-tyrosine dephosphorylation neuron projection development negative regulation of angiogenesis Components cell-cell junction cytoplasm cell-cell adherens junction perinuclear region of cytoplasm lamellipodium integral component of plasma membrane
General Function	Transmembrane receptor protein tyrosine phosphatase activity
Specific Function	Involved in cell-cell adhesion through homophilic interactions. May play a key role in signal transduction and growth control.
Transmembrane Regions	743-764
GenBank Protein ID
UniProtKB ID	P28827
UniProtKB Entry Name	PTPRM_HUMAN
Cellular Location	Membrane
Gene sequence	>lcl\|BSEQ0013562\|Receptor-type tyrosine-protein phosphatase mu (PTPRM) ATGAGGGGACTTGGGACTTGCCTGGCGACTTTGGCCGGACTTTTGCTAACTGCGGCGGGC GAGACGTTCTCAGGTGGCTGCCTCTTTGATGAGCCGTATAGCACATGTGGATATAGTCAA TCTGAAGGTGATGACTTCAATTGGGAGCAAGTGAACACCTTGACTAAACCGACTTCTGAT CCATGGATGCCATCAGGTTCTTTCATGCTGGTGAATGCCTCTGGGAGACCTGAGGGGCAG AGAGCCCACCTGCTCTTACCCCAACTTAAAGAAAATGACACCCACTGCATCGATTTTCAC TATTTTGTGTCCAGCAAGAGTAATTCTCCTCCGGGGTTACTCAATGTCTACGTGAAGGTC AATAACGGGCCACTGGGGAATCCTATCTGGAATATATCTGGAGACCCAACACGTACATGG AACAGGGCAGAACTGGCCATTAGTACTTTCTGGCCTAACTTTTATCAGGTGATTTTTGAA GTGATAACTTCTGGACATCAAGGCTATCTCGCTATCGATGAGGTGAAGGTGTTAGGACAT CCATGTACCAGGACTCCTCACTTCCTGCGGATTCAGAATGTGGAAGTTAATGCTGGCCAG TTTGCTACCTTCCAGTGCAGTGCCATCGGCAGGACCGTGGCAGGAGACAGGCTCTGGTTA CAGGGCATTGATGTGCGAGATGCTCCTCTGAAGGAAATCAAGGTGACCAGCTCCCGACGC TTCATTGCTTCATTTAATGTTGTGAATACCACCAAACGAGATGCTGGAAAGTACCGCTGC ATGATTCGCACTGAAGGAGGTGTTGGAATATCAAACTATGCAGAGTTGGTAGTTAAAGAA CCACCCGTTCCTATTGCCCCACCTCAGCTCGCCTCTGTAGGAGCCACCTACCTGTGGATA CAGCTCAACGCCAACTCCATCAATGGGGATGGGCCCATTGTGGCCCGAGAGGTGGAGTAC TGCACGGCCAGTGGGAGCTGGAATGACCGGCAGCCAGTCGATTCCACGAGCTATAAAATT GGACACCTTGACCCAGATACAGAATATGAGATTAGTGTGCTCCTGACCAGGCCAGGGGAG GGTGGCACTGGCTCTCCTGGTCCAGCTCTCAGGACAAGAACAAAGTGTGCTGATCCCATG CGAGGCCCAAGAAAACTAGAAGTAGTGGAGGTCAAATCTCGGCAAATCACTATCCGCTGG GAGCCATTTGGATATAATGTAACTCGTTGCCACAGTTATAATCTCACTGTCCACTACTGT TACCAAGTTGGAGGACAAGAACAAGTGCGAGAAGAAGTAAGCTGGGATACAGAAAACTCA CACCCTCAACACACGATCACTAACCTGTCACCATACACCAATGTCAGTGTGAAACTGATC CTCATGAACCCAGAGGGCCGGAAGGAAAGCCAAGAACTCATAGTGCAGACAGATGAAGAC CTCCCAGGTGCTGTTCCCACTGAATCCATACAAGGAAGTACCTTTGAAGAGAAGATATTT CTTCAGTGGAGAGAACCAACTCAAACATATGGTGTAATCACTTTATATGAGATCACCTAC AAAGCAGTCAGTTCCTTTGACCCAGAAATAGATTTATCCAATCAGAGTGGAAGAGTTTCA AAGCTGGGAAATGAAACCCATTTTCTGTTTTTTGGACTGTATCCGGGGACCACATACTCC TTTACCATCCGAGCTAGCACAGCTAAGGGTTTTGGGCCTCCAGCAACAAACCAGTTCACC ACCAAAATATCAGCACCCTCTATGCCAGCTTATGAACTTGAGACACCTTTGAATCAAACT GACAATACCGTGACAGTCATGCTGAAACCTGCCCACAGCAGAGGAGCACCTGTCAGTGTC TATCAAATAGTTGTTGAGGAAGAACGTCCTCGAAGAACTAAAAAGACGACAGAAATCTTA AAGTGCTACCCAGTGCCAATTCACTTCCAGAATGCTTCTCTGCTGAACTCACAGTACTAC TTTGCTGCAGAATTTCCTGCAGACAGCCTCCAAGCTGCGCAGCCTTTTACAATTGGTGAT AATAAGACATATAATGGATACTGGAACACTCCCCTTCTCCCCTATAAAAGCTACAGAATT TATTTCCAAGCTGCTAGTAGAGCCAATGGGGAAACCAAAATAGACTGTGTCCAAGTGGCC ACAAAAGGAGCTGCCACTCCGAAACCAGTCCCAGAACCCGAGAAACAGACAGACCATACA GTTAAAATTGCTGGAGTCATCGCGGGCATCTTGCTGTTCGTGATTATATTTCTTGGAGTT GTGTTGGTAATGAAGAAAAGGAAACTGGCCAAGAAGCGGAAAGAGACCATGAGCAGCACC CGACAGGAGATGACTGTGATGGTGAACTCAATGGACAAGAGCTATGCTGAGCAGGGCACA AACTGCGACGAGGCTTTCTCATTCATGGACACGCACAATCTGAATGGGAGATCTGTGTCT TCACCATCGTCCTTCACAATGAAAACAAATACACTGAGCACATCGGTGCCTAATTCCTAT TACCCAGACCCATTTGTGCCAACTGCAATTTTAGTGCCAATAAATGATGAAACCCACACA ATGGCCAGCGATACCAGCAGCCTGGTGCAGTCCCATACTTACAAGAAGCGAGAGCCGGCC GACGTGCCCTATCAGACTGGGCAGCTCCACCCCGCCATCCGGGTGGCAGACCTCCTTCAG CACATCACACAGATGAAGTGTGCGGAGGGCTACGGCTTCAAGGAGGAATACGAGAGCTTC TTTGAAGGGCAGTCTGCACCATGGGACTCGGCTAAGAAAGATGAGAACAGAATGAAGAAC AGATACGGGAATATCATTGCATACGATCATTCCCGAGTGAGGCTGCAGACAATAGAAGGA GACACAAACTCAGACTATATCAATGGCAATTATATCGATGGTTATCATCGACCCAATCAT TACATTGCTACCCAAGGGCCAATGCAGGAAACCATCTATGACTTCTGGAGGATGGTGTGG CACGAAAACACTGCAAGTATCATCATGGTGACCAATCTTGTGGAAGTGGGAAGGGTCAAA TGCTGCAAATACTGGCCAGATGACACAGAGATATATAAAGACATTAAAGTTACCCTAATA GAAACAGAACTACTGGCAGAATATGTGATAAGAACATTTGCTGTTGAAAAGAGAGGTGTG CATGAAATCCGAGAGATCAGACAGTTTCACTTCACTGGCTGGCCGGATCATGGGGTCCCC TACCATGCCACCGGCCTGCTGGGATTCGTGCGGCAAGTCAAGTCCAAGAGCCCGCCCAGT GCAGGCCCACTGGTGGTGCACTGCAGTGCTGGTGCAGGGAGGACTGGCTGTTTCATCGTC ATTGATATCATGTTGGACATGGCCGAAAGGGAAGGGGTCGTAGACATCTACAACTGCGTC AGGGAGCTGCGGTCACGGAGGGTGAACATGGTGCAAACAGAGGAGCAGTATGTGTTTATC CACGATGCGATCCTGGAAGCCTGTCTTTGTGGGGACACCTCTGTGCCTGCTTCCCAAGTT AGGTCTCTGTATTATGACATGAACAAACTGGATCCACAGACAAACTCAAGCCAGATTAAA GAGGAATTCCGGACGCTAAACATGGTGACACCAACGCTGCGAGTAGAGGACTGCAGCATC GCACTGTTGCCCCGGAACCATGAGAAAAACCGGTGCATGGACATCCTGCCCCCAGACCGC TGCCTGCCCTTCCTCATCACCATCGATGGGGAGAGCAGCAACTACATCAATGCTGCCCTC ATGGACAGCTATAAACAGCCTTCAGCTTTTATAGTCACCCAGCATCCTTTGCCAAACACA GTGAAAGACTTTTGGAGACTGGTCCTGGATTATCACTGCACATCCGTAGTTATGCTAAAT GATGTGGATCCTGCCCAGTTGTGTCCACAGTACTGGCCAGAAAACGGAGTACACAGACAC GGCCCCATCCAGGTGGAATTTGTCTCTGCTGACCTGGAAGAGGACATCATCAGCAGGATA TTCCGCATTTACAATGCCGCCAGACCCCAAGATGGATATCGGATGGTGCAGCAATTCCAG TTCCTGGGCTGGCCGATGTACAGGGACACACCAGTGTCTAAGCGCTCCTTCTTGAAGCTC ATTCGCCAGGTGGACAAGTGGCAAGAGGAGTACAATGGCGGGGAAGGCCGCACGGTTGTG CACTGCTTGAACGGGGGAGGCCGCAGTGGGACGTTCTGCGCCATCAGCATCGTATGTGAG ATGCTCCGGCACCAGAGAACCGTGGATGTCTTTCACGCTGTGAAGACACTGAGGAACAAC AAGCCCAACATGGTCGACCTCCTGGATCAGTACAAGTTCTGCTACGAGGTGGCCCTGGAA TACTTGAATTCTGGCTGA
GenBank Gene ID
GeneCard ID	None
GenAtlas ID
HGNC ID	HGNC:9675
Chromosome Location	18
Locus	None
References	Hoffmann KM, Tonks NK, Barford D: The crystal structure of domain 1 of receptor protein-tyrosine phosphatase mu. J Biol Chem. 1997 Oct 31;272(44):27505-8.[9346878 ] Aricescu AR, Hon WC, Siebold C, Lu W, van der Merwe PA, Jones EY: Molecular analysis of receptor protein tyrosine phosphatase mu-mediated cell adhesion. EMBO J. 2006 Feb 22;25(4):701-12. Epub 2006 Feb 2.[16456543 ] Dephoure N, Zhou C, Villen J, Beausoleil SA, Bakalarski CE, Elledge SJ, Gygi SP: A quantitative atlas of mitotic phosphorylation. Proc Natl Acad Sci U S A. 2008 Aug 5;105(31):10762-7. doi: 10.1073/pnas.0805139105. Epub 2008 Jul 31.[18669648 ] Gebbink MF, van Etten I, Hateboer G, Suijkerbuijk R, Beijersbergen RL, Geurts van Kessel A, Moolenaar WH: Cloning, expression and chromosomal localization of a new putative receptor-like protein tyrosine phosphatase. FEBS Lett. 1991 Sep 23;290(1-2):123-30.[1655529 ] Nusbaum C, Zody MC, Borowsky ML, Kamal M, Kodira CD, Taylor TD, Whittaker CA, Chang JL, Cuomo CA, Dewar K, FitzGerald MG, Yang X, Abouelleil A, Allen NR, Anderson S, Bloom T, Bugalter B, Butler J, Cook A, DeCaprio D, Engels R, Garber M, Gnirke A, Hafez N, Hall JL, Norman CH, Itoh T, Jaffe DB, Kuroki Y, Lehoczky J, Lui A, Macdonald P, Mauceli E, Mikkelsen TS, Naylor JW, Nicol R, Nguyen C, Noguchi H, O'Leary SB, O'Neill K, Piqani B, Smith CL, Talamas JA, Topham K, Totoki Y, Toyoda A, Wain HM, Young SK, Zeng Q, Zimmer AR, Fujiyama A, Hattori M, Birren BW, Sakaki Y, Lander ES: DNA sequence and analysis of human chromosome 18. Nature. 2005 Sep 22;437(7058):551-5.[16177791 ] Liu T, Qian WJ, Gritsenko MA, Camp DG 2nd, Monroe ME, Moore RJ, Smith RD: Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry. J Proteome Res. 2005 Nov-Dec;4(6):2070-80.[16335952 ] Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. 2004 Oct;14(10B):2121-7.[15489334 ]

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FRCD

Receptor-type tyrosine-protein phosphatase mu

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