ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1
Name | ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 |
---|---|
Synonyms | 2'-phospho-ADP-ribosyl cyclase 2'-phospho-ADP-ribosyl cyclase/2'-phospho-cyclic-ADP-ribose transferase 2'-phospho-cyclic-ADP-ribose transferase 3.2.2.6 ADP-ribosyl cyclase 1 ADPRC 1 cADPr hydrolase 1 Cyclic ADP-ribose hydrolase 1 T10 |
Gene Name | CD38 |
Organism | Human |
Amino acid sequence | >lcl|BSEQ0009207|ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 MANCEFSPVSGDKPCCRLSRRAQLCLGVSILVLILVVVLAVVVPRWRQQWSGPGTTKRFP ETVLARCVKYTEIHPEMRHVDCQSVWDAFKGAFISKHPCNITEEDYQPLMKLGTQTVPCN KILLWSRIKDLAHQFTQVQRDMFTLEDTLLGYLADDLTWCGEFNTSKINYQSCPDWRKDC SNNPVSVFWKTVSRRFAEAACDVVHVMLNGSRSKIFDKNSTFGSVEVHNLQPEKVQTLEA WVIHGGREDSRDLCQDPTIKELESIISKRNIQFSCKNIYRPDKFLQCVKNPEDSSCTSEI |
Number of residues | 300 |
Molecular Weight | 34328.145 |
Theoretical pI | None |
GO Classification |
Functions
NAD(P)+ nucleosidase activity transferase activity phosphorus-oxygen lyase activity NAD+ nucleosidase activity Processes
female pregnancy B cell receptor signaling pathway long term synaptic depression response to retinoic acid positive regulation of vasoconstriction apoptotic signaling pathway negative regulation of transcription, DNA-templated signal transduction positive regulation of cytosolic calcium ion concentration positive regulation of insulin secretion positive regulation of transcription, DNA-templated response to progesterone response to drug response to estradiol response to interleukin-1 negative regulation of apoptotic process response to hydroperoxide response to hypoxia positive regulation of B cell proliferation positive regulation of cell growth negative regulation of bone resorption Components
cell surface integral component of membrane cytosol membrane extracellular exosome nucleus plasma membrane |
General Function | Transferase activity |
Specific Function | Synthesizes the second messagers cyclic ADP-ribose and nicotinate-adenine dinucleotide phosphate, the former a second messenger for glucose-induced insulin secretion. Also has cADPr hydrolase activity. Also moonlights as a receptor in cells of the immune system. |
Transmembrane Regions | 22-42 |
GenBank Protein ID | |
UniProtKB ID | P28907 |
UniProtKB Entry Name | CD38_HUMAN |
Cellular Location | Membrane |
Gene sequence | >lcl|BSEQ0013673|ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 (CD38) ATGGCCAACTGCGAGTTCAGCCCGGTGTCCGGGGACAAACCCTGCTGCCGGCTCTCTAGG AGAGCCCAACTCTGTCTTGGCGTCAGTATCCTGGTCCTGATCCTCGTCGTGGTGCTCGCG GTGGTCGTCCCGAGGTGGCGCCAGCAGTGGAGCGGTCCGGGCACCACCAAGCGCTTTCCC GAGACCGTCCTGGCGCGATGCGTCAAGTACACTGAAATTCATCCTGAGATGAGACATGTA GACTGCCAAAGTGTATGGGATGCTTTCAAGGGTGCATTTATTTCAAAACATCCTTGCAAC ATTACTGAAGAAGACTATCAGCCACTAATGAAGTTGGGAACTCAGACCGTACCTTGCAAC AAGATTCTTCTTTGGAGCAGAATAAAAGATCTGGCCCATCAGTTCACACAGGTCCAGCGG GACATGTTCACCCTGGAGGACACGCTGCTAGGCTACCTTGCTGATGACCTCACATGGTGT GGTGAATTCAACACTTCCAAAATAAACTATCAATCTTGCCCAGACTGGAGAAAGGACTGC AGCAACAACCCTGTTTCAGTATTCTGGAAAACGGTTTCCCGCAGGTTTGCAGAAGCTGCC TGTGATGTGGTCCATGTGATGCTCAATGGATCCCGCAGTAAAATCTTTGACAAAAACAGC ACTTTTGGGAGTGTGGAAGTCCATAATTTGCAACCAGAGAAGGTTCAGACACTAGAGGCC TGGGTGATACATGGTGGAAGAGAAGATTCCAGAGACTTATGCCAGGATCCCACCATAAAA GAGCTGGAATCGATTATAAGCAAAAGGAATATTCAATTTTCCTGCAAGAATATCTACAGA CCTGACAAGTTTCTTCAGTGTGTGAAAAATCCTGAGGATTCATCTTGCACATCTGAGATC TGA |
GenBank Gene ID | |
GeneCard ID | None |
GenAtlas ID | |
HGNC ID | HGNC:1667 |
Chromosome Location | 4 |
Locus | None |
References |
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