Adenosine receptor A2a
Name | Adenosine receptor A2a |
---|---|
Synonyms | ADORA2 |
Gene Name | ADORA2A |
Organism | Human |
Amino acid sequence | >lcl|BSEQ0001840|Adenosine receptor A2a MPIMGSSVYITVELAIAVLAILGNVLVCWAVWLNSNLQNVTNYFVVSLAAADIAVGVLAI PFAITISTGFCAACHGCLFIACFVLVLTQSSIFSLLAIAIDRYIAIRIPLRYNGLVTGTR AKGIIAICWVLSFAIGLTPMLGWNNCGQPKEGKNHSQGCGEGQVACLFEDVVPMNYMVYF NFFACVLVPLLLMLGVYLRIFLAARRQLKQMESQPLPGERARSTLQKEVHAAKSLAIIVG LFALCWLPLHIINCFTFFCPDCSHAPLWLMYLAIVLSHTNSVVNPFIYAYRIREFRQTFR KIIRSHVLRQQEPFKAAGTSARVLAAHGSDGEQVSLRLNGHPPGVWANGSAPHPERRPNG YALGLVSGGSAQESQGNTGLPDVELLSHELKGVCPEPPGLDDPLAQDGAGVS |
Number of residues | 412 |
Molecular Weight | 44706.925 |
Theoretical pI | 8.05 |
GO Classification |
Functions
G-protein coupled adenosine receptor activity enzyme binding identical protein binding Processes
positive regulation of acetylcholine secretion, neurotransmission cellular protein metabolic process excitatory postsynaptic potential locomotory behavior positive regulation of synaptic transmission, glutamatergic response to drug positive regulation of circadian sleep/wake cycle, sleep activation of adenylate cyclase activity phagocytosis response to amphetamine negative regulation of vascular permeability regulation of norepinephrine secretion apoptotic process regulation of synaptic plasticity positive regulation of adenylate cyclase activity involved in G-protein coupled receptor signaling pathway positive regulation of urine volume inflammatory response regulation of mitochondrial membrane potential negative regulation of cell proliferation cAMP biosynthetic process vasodilation cell-cell signaling cellular defense response negative regulation of cysteine-type endopeptidase activity involved in apoptotic process central nervous system development negative regulation of inflammatory response neuron projection morphogenesis sensory perception adenylate cyclase-modulating G-protein coupled receptor signaling pathway neurotrophin TRK receptor signaling pathway inhibitory postsynaptic potential negative regulation of locomotion negative regulation of neuron apoptotic process positive regulation of synaptic transmission, GABAergic blood circulation regulation of calcium ion transport negative regulation of protein kinase activity positive regulation of apoptotic signaling pathway synaptic transmission, glutamatergic synaptic transmission, dopaminergic regulation of transcription, DNA-templated response to caffeine eating behavior transmembrane receptor protein tyrosine kinase signaling pathway positive regulation of glutamate secretion astrocyte activation synaptic transmission, cholinergic positive regulation of protein secretion blood coagulation positive regulation of renal sodium excretion negative regulation of alpha-beta T cell activation protein kinase C-activating G-protein coupled receptor signaling pathway prepulse inhibition membrane depolarization Components
neuronal cell body plasma membrane presynaptic membrane postsynaptic density endomembrane system asymmetric synapse membrane intermediate filament dendrite integral component of plasma membrane axolemma presynaptic active zone postsynaptic membrane |
General Function | Identical protein binding |
Specific Function | Receptor for adenosine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. |
Transmembrane Regions | 8-32 43-66 78-100 121-143 174-198 235-258 267-290 |
GenBank Protein ID | 177892 |
UniProtKB ID | P29274 |
UniProtKB Entry Name | AA2AR_HUMAN |
Cellular Location | Cell membrane |
Gene sequence | >lcl|BSEQ0016254|Adenosine receptor A2a (ADORA2A) ATGCCCATCATGGGCTCCTCGGTGTACATCACGGTGGAGCTGGCCATTGCTGTGCTGGCC ATCCTGGGCAATGTGCTGGTGTGCTGGGCCGTGTGGCTCAACAGCAACCTGCAGAACGTC ACCAACTACTTTGTGGTGTCACTGGCGGCGGCCGACATCGCAGTGGGTGTGCTCGCCATC CCCTTTGCCATCACCATCAGCACCGGGTTCTGCGCTGCCTGCCACGGCTGCCTCTTCATT GCCTGCTTCGTCCTGGTCCTCACGCAGAGCTCCATCTTCAGTCTCCTGGCCATCGCCATT GACCGCTACATTGCCATCCGCATCCCGCTCCGGTACAATGGCTTGGTGACCGGCACGAGG GCTAAGGGCATCATTGCCATCTGCTGGGTGCTGTCGTTTGCCATCGGCCTGACTCCCATG CTAGGTTGGAACAACTGCGGTCAGCCAAAGGAGGGCAAGAACCACTCCCAGGGCTGCGGG GAGGGCCAAGTGGCCTGTCTCTTTGAGGATGTGGTCCCCATGAACTACATGGTGTACTTC AACTTCTTTGCCTGTGTGCTGGTGCCCCTGCTGCTCATGCTGGGTGTCTATTTGCGGATC TTCCTGGCGGCGCGACGACAGCTGAAGCAGATGGAGAGCCAGCCTCTGCCGGGGGAGCGG GCACGGTCCACACTGCAGAAGGAGGTCCATGCTGCCAAGTCACTGGCCATCATTGTGGGG CTCTTTGCCCTCTGCTGGCTGCCCCTACACATCATCAACTGCTTCACTTTCTTCTGCCCC GACTGCAGCCACGCCCCTCTCTGGCTCATGTACCTGGCCATCGTCCTCTCCCACACCAAT TCGGTTGTGAATCCCTTCATCTACGCCTACCGTATCCGCGAGTTCCGCCAGACCTTCCGC AAGATCATTCGCAGCCACGTCCTGAGGCAGCAAGAACCTTTCAAGGCAGCTGGCACCAGT GCCCGGGTCTTGGCAGCTCATGGCAGTGACGGAGAGCAGGTCAGCCTCCGTCTCAACGGC CACCCGCCAGGAGTGTGGGCCAACGGCAGTGCTCCCCACCCTGAGCGGAGGCCCAATGGC TATGCCCTGGGGCTGGTGAGTGGAGGGAGTGCCCAAGAGTCCCAGGGGAACACGGGCCTC CCAGACGTGGAGCTCCTTAGCCATGAGCTCAAGGGAGTGTGCCCAGAGCCCCCTGGCCTA GATGACCCCCTGGCCCAGGATGGAGCAGGAGTGTCCTGA |
GenBank Gene ID | M97370 |
GeneCard ID | None |
GenAtlas ID | ADORA2A |
HGNC ID | HGNC:263 |
Chromosome Location | 22 |
Locus | 22q11.23 |
References |
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Related FRC
FRCD ID | Name | Exact Mass | Structure |
---|---|---|---|
Acifluorfen |
361.657 |
||
Malathion |
330.35 |
||
Prometryn |
241.357 |
||
Adenosine |
267.245 |
||
Quercetin |
302.238 |
||
Theophylline |
180.167 |
||
Caffeine |
194.19 |
||
Mercuric chloride |
271.492 |