Aquaporin-1
Name | Aquaporin-1 |
---|---|
Synonyms | AQP-1 Aquaporin-CHIP CHIP28 Urine water channel Water channel protein for red blood cells and kidney proximal tubule |
Gene Name | AQP1 |
Organism | Human |
Amino acid sequence | >lcl|BSEQ0001754|Aquaporin-1 MASEFKKKLFWRAVVAEFLATTLFVFISIGSALGFKYPVGNNQTAVQDNVKVSLAFGLSI ATLAQSVGHISGAHLNPAVTLGLLLSCQISIFRALMYIIAQCVGAIVATAILSGITSSLT GNSLGRNDLADGVNSGQGLGIEIIGTLQLVLCVLATTDRRRRDLGGSAPLAIGLSVALGH LLAIDYTGCGINPARSFGSAVITHNFSNHWIFWVGPFIGGALAVLIYDFILAPRSSDLTD RVKVWTSGQVEEYDLDADDINSRVEMKPK |
Number of residues | 269 |
Molecular Weight | 28525.68 |
Theoretical pI | 7.5 |
GO Classification |
Functions
carbon dioxide transmembrane transporter activity transmembrane transporter activity potassium ion transmembrane transporter activity intracellular cGMP activated cation channel activity nitric oxide transmembrane transporter activity glycerol transmembrane transporter activity water transmembrane transporter activity glycerol channel activity potassium channel activity water channel activity ammonium transmembrane transporter activity Processes
potassium ion transmembrane transport cellular response to copper ion renal water homeostasis cerebrospinal fluid secretion water transport transmembrane transport cellular homeostasis cell volume homeostasis cellular response to UV cellular response to cAMP cellular response to mechanical stimulus positive regulation of saliva secretion multicellular organismal water homeostasis carbon dioxide transport cation transmembrane transport carbon dioxide transmembrane transport cellular response to retinoic acid positive regulation of fibroblast proliferation potassium ion transport pancreatic juice secretion cellular hyperosmotic response negative regulation of apoptotic process cellular response to salt stress cellular response to hypoxia response to drug cellular response to nitric oxide cellular response to inorganic substance negative regulation of cysteine-type endopeptidase activity involved in apoptotic process positive regulation of angiogenesis cellular response to mercury ion cGMP biosynthetic process cellular response to stress renal water transport nitric oxide transport establishment or maintenance of actin cytoskeleton polarity cellular water homeostasis bicarbonate transport small molecule metabolic process ammonium transmembrane transport maintenance of symbiont-containing vacuole by host glycerol transport cellular response to dexamethasone stimulus ammonium transport odontogenesis transepithelial water transport lateral ventricle development cellular response to hydrogen peroxide Components
symbiont-containing vacuole nuclear membrane brush border integral component of plasma membrane cytoplasm nucleus sarcolemma basolateral plasma membrane apical part of cell plasma membrane apical plasma membrane brush border membrane extracellular exosome basal plasma membrane |
General Function | Water transmembrane transporter activity |
Specific Function | Forms a water-specific channel that provides the plasma membranes of red cells and kidney proximal tubules with high permeability to water, thereby permitting water to move in the direction of an osmotic gradient. |
Transmembrane Regions | 8-36 49-66 95-115 137-155 167-183 208-228 |
GenBank Protein ID | 180501 |
UniProtKB ID | P29972 |
UniProtKB Entry Name | AQP1_HUMAN |
Cellular Location | Cell membrane |
Gene sequence | >lcl|BSEQ0021277|Aquaporin-1 (AQP1) ATGCCTGGGGCTCGCCCCTTGCCTCTGGTCTTGGTACCCCAGAATACCCTGGCCTGGATG CAGCTGGATGCAAAGGCCCCAGCTCACCCCAGGCCTCTCCAGCTTCTAGGCAGAGTGGGG CCTGGGTCTAGGCAGCTGGCTGATGGTGTGAACTCGGGCCAGGGCCTGGGCATCGAGATC ATCGGGACCCTCCAGCTGGTGCTATGCGTGCTGGCTACTACCGACCGGAGGCGCCGTGAC CTTGGTGGCTCAGCCCCCCTTGCCATCGGCCTCTCTGTAGCCCTTGGACACCTCCTGGCT ATTGACTACACTGGCTGTGGGATTAACCCTGCTCGGTCCTTTGGCTCCGCGGTGATCACA CACAACTTCAGCAACCACTGGATTTTCTGGGTGGGGCCATTCATCGGGGGAGCCCTGGCT GTACTCATCTACGACTTCATCCTGGCCCCACGCAGCAGTGACCTCACAGACCGCGTGAAG GTGTGGACCAGCGGCCAGGTGGAGGAGTATGACCTGGATGCCGACGACATCAACTCCAGG GTGGAGATGAAGCCCAAATAG |
GenBank Gene ID | M77829 |
GeneCard ID | None |
GenAtlas ID | AQP1 |
HGNC ID | HGNC:633 |
Chromosome Location | 7 |
Locus | 7p14 |
References |
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