Translocator protein
Name | Translocator protein |
---|---|
Synonyms | BZRP MBR Mitochondrial benzodiazepine receptor PBR Peripheral-type benzodiazepine receptor PKBS |
Gene Name | TSPO |
Organism | Human |
Amino acid sequence | >lcl|BSEQ0037065|Translocator protein MAPPWVPAMGFTLAPSLGCFVGSRFVHGEGLRWYAGLQKPSWHPPHWVLGPVWGTLYSAM GYGSYLVWKELGGFTEKAVVPLGLYTGQLALNWAWPPIFFGARQMGWALVDLLLVSGAAA ATTVAWYQVSPLAARLLYPYLAWLAFTTTLNYCVWRDNHGWRGGRRLPE |
Number of residues | 169 |
Molecular Weight | 18827.81 |
Theoretical pI | 9.33 |
GO Classification |
Functions
androgen binding benzodiazepine receptor activity cholesterol binding Processes
contact inhibition cellular response to lipopolysaccharide steroid biosynthetic process positive regulation of necrotic cell death cellular hypotonic response positive regulation of calcium ion transport negative regulation of glial cell proliferation adrenal gland development response to testosterone regulation of cholesterol transport aging negative regulation of tumor necrosis factor production positive regulation of apoptotic process response to manganese ion anion transport positive regulation of mitochondrial depolarization heme biosynthetic process chloride transport positive regulation of glial cell proliferation steroid metabolic process response to vitamin B1 response to drug regulation of steroid biosynthetic process apoptotic process response to progesterone lipid transport negative regulation of nitric oxide biosynthetic process positive regulation of reactive oxygen species metabolic process behavioral response to pain cell proliferation cellular response to zinc ion glial cell migration peripheral nervous system axon regeneration protein targeting to mitochondrion Components
integral component of membrane extracellular exosome cytoplasm nuclear membrane mitochondrion intracellular membrane-bounded organelle mitochondrial outer membrane |
General Function | Cholesterol binding |
Specific Function | Can bind protoporphyrin IX and may play a role in the transport of porphyrins and heme (By similarity). Promotes the transport of cholesterol across mitochondrial membranes and may play a role in lipid metabolism (PubMed:24814875), but its precise physiological role is controversial. It is apparently not required for steroid hormone biosynthesis. Was initially identified as peripheral-type benzodiazepine receptor; can also bind isoquinoline carboxamides (PubMed:1847678). |
Transmembrane Regions | 6-26 47-67 80-100 106-126 135-155 |
GenBank Protein ID | 306883 |
UniProtKB ID | P30536 |
UniProtKB Entry Name | TSPOA_HUMAN |
Cellular Location | Mitochondrion membrane |
Gene sequence | >lcl|BSEQ0016193|Translocator protein (TSPO) ATGGCCCCGCCCTGGGTGCCCGCCATGGGCTTCACGCTGGCGCCCAGCCTGGGGTGCTTC GTGGGCTCCCGCTTTGTCCACGGCGAGGGTCTCCGCTGGTACGCCGGCCTGCAGAAGCCC TCGTGGCACCCGCCCCACTGGGTGCTGGGCCCTGTCTGGGGCACGCTCTACTCAGCCATG GGGTACGGCTCCTACCTGGTCTGGAAAGAGCTGGGAGGCTTCACAGAGAAGGCTGTGGTT CCCCTGGGCCTCTACACTGGGCAGCTGGCCCTGAACTGGGCATGGCCCCCCATCTTCTTT GGTGCCCGACAAATGGGCTGGGCCTTGGTGGATCTCCTGCTGGTCAGTGGGGCGGCGGCA GCCACTACCGTGGCCTGGTACCAGGTGAGCCCGCTGGCCGCCCGCCTGCTCTACCCCTAC CTGGCCTGGCTGGCCTTCACGACCACACTCAACTACTGCGTATGGCGGGACAACCATGGC TGGCGTGGGGGACGGCGGCTGCCAGAGTGA |
GenBank Gene ID | M36035 |
GeneCard ID | None |
GenAtlas ID | TSPO |
HGNC ID | HGNC:1158 |
Chromosome Location | 22 |
Locus | 22q13.31 |
References |
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