Adenosine receptor A1
Name | Adenosine receptor A1 |
---|---|
Synonyms | |
Gene Name | ADORA1 |
Organism | Human |
Amino acid sequence | >lcl|BSEQ0000026|Adenosine receptor A1 MPPSISAFQAAYIGIEVLIALVSVPGNVLVIWAVKVNQALRDATFCFIVSLAVADVAVGA LVIPLAILINIGPQTYFHTCLMVACPVLILTQSSILALLAIAVDRYLRVKIPLRYKMVVT PRRAAVAIAGCWILSFVVGLTPMFGWNNLSAVERAWAANGSMGEPVIKCEFEKVISMEYM VYFNFFVWVLPPLLLMVLIYLEVFYLIRKQLNKKVSASSGDPQKYYGKELKIAKSLALIL FLFALSWLPLHILNCITLFCPSCHKPSILTYIAIFLTHGNSAMNPIVYAFRIQKFRVTFL KIWNDHFRCQPAPPIDEDLPEERPDD |
Number of residues | 326 |
Molecular Weight | 36511.325 |
Theoretical pI | 8.75 |
GO Classification |
Functions
G-protein coupled adenosine receptor activity purine nucleoside binding phospholipase C activity Processes
positive regulation of blood pressure protein targeting to membrane negative regulation of glutamate secretion regulation of sensory perception of pain negative regulation of synaptic transmission, GABAergic positive regulation of nucleoside transport negative regulation of hormone secretion regulation of synaptic plasticity positive regulation of peptide secretion activation of MAPKK activity negative regulation of leukocyte migration temperature homeostasis adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway positive regulation of potassium ion transport negative regulation of apoptotic process negative regulation of lipid catabolic process negative regulation of blood pressure positive regulation of protein dephosphorylation signal transduction negative regulation of cell proliferation negative regulation of long term synaptic depression negative regulation of cardiac muscle contraction regulation of glomerular filtration response to hypoxia negative regulation of mucus secretion detection of temperature stimulus involved in sensory perception of pain negative regulation of neurotrophin production excitatory postsynaptic potential negative regulation of synaptic transmission, glutamatergic relaxation of vascular smooth muscle lipid catabolic process inflammatory response nervous system development negative regulation of vasodilation apoptotic signaling pathway negative regulation of acute inflammatory response phagocytosis negative regulation of renal sodium excretion cell-cell signaling negative regulation of circadian sleep/wake cycle, non-REM sleep regulation of respiratory gaseous exchange by neurological system process cognition positive regulation of epidermal growth factor-activated receptor activity Components
axolemma integral component of plasma membrane dendritic spine presynaptic active zone terminal bouton postsynaptic membrane neuronal cell body endoplasmic reticulum asymmetric synapse presynaptic membrane plasma membrane basolateral plasma membrane postsynaptic density |
General Function | Purine nucleoside binding |
Specific Function | Receptor for adenosine. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase. |
Transmembrane Regions | 11-33 47-69 81-102 124-146 177-201 236-259 268-292 |
GenBank Protein ID | 256155 |
UniProtKB ID | P30542 |
UniProtKB Entry Name | AA1R_HUMAN |
Cellular Location | Cell membrane |
Gene sequence | >lcl|BSEQ0010133|Adenosine receptor A1 (ADORA1) ATGCCGCCCTCCATCTCAGCTTTCCAGGCCGCCTACATCGGCATCGAGGTGCTCATCGCC CTGGTCTCTGTGCCCGGGAACGTGCTGGTGATCTGGGCGGTGAAGGTGAACCAGGCGCTG CGGGATGCCACCTTCTGCTTCATCGTGTCGCTGGCGGTGGCTGATGTGGCCGTGGGTGCC CTGGTCATCCCCCTCGCCATCCTCATCAACATTGGGCCACAGACCTACTTCCACACCTGC CTCATGGTTGCCTGTCCGGTCCTCATCCTCACCCAGAGCTCCATCCTGGCCCTGCTGGCA ATTGCTGTGGACCGCTACCTCCGGGTCAAGATCCCTCTCCGGTACAAGATGGTGGTGACC CCCCGGAGGGCGGCGGTGGCCATAGCCGGCTGCTGGATCCTCTCCTTCGTGGTGGGACTG ACCCCTATGTTTGGCTGGAACAATCTGAGTGCGGTGGAGCGGGCCTGGGCAGCCAACGGC AGCATGGGGGAGCCCGTGATCAAGTGCGAGTTCGAGAAGGTCATCAGCATGGAGTACATG GTCTACTTCAACTTCTTTGTGTGGGTGCTGCCCCCGCTTCTCCTCATGGTCCTCATCTAC CTGGAGGTCTTCTACCTAATCCGCAAGCAGCTCAACAAGAAGGTGTCGGCCTCCTCCGGC GACCCGCAGAAGTACTATGGGAAGGAGCTGAAGATCGCCAAGTCGCTGGCCCTCATCCTC TTCCTCTTTGCCCTCAGCTGGCTGCCTTTGCACATCCTCAACTGCATCACCCTCTTCTGC CCGTCCTGCCACAAGCCCAGCATCCTTACCTACATTGCCATCTTCCTCACGCACGGCAAC TCGGCCATGAACCCCATTGTCTATGCCTTCCGCATCCAGAAGTTCCGCGTCACCTTCCTT AAGATTTGGAATGACCATTTCCGCTGCCAGCCTGCACCTCCCATTGACGAGGATCTCCCA GAAGAGAGGCCTGATGACTAG |
GenBank Gene ID | S45235 |
GeneCard ID | None |
GenAtlas ID | ADORA1 |
HGNC ID | HGNC:262 |
Chromosome Location | 1 |
Locus | 1q32.1 |
References |
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