Adenosine receptor A1


NameAdenosine receptor A1
Synonyms
Gene NameADORA1
OrganismHuman
Amino acid sequence
>lcl|BSEQ0000026|Adenosine receptor A1
MPPSISAFQAAYIGIEVLIALVSVPGNVLVIWAVKVNQALRDATFCFIVSLAVADVAVGA
LVIPLAILINIGPQTYFHTCLMVACPVLILTQSSILALLAIAVDRYLRVKIPLRYKMVVT
PRRAAVAIAGCWILSFVVGLTPMFGWNNLSAVERAWAANGSMGEPVIKCEFEKVISMEYM
VYFNFFVWVLPPLLLMVLIYLEVFYLIRKQLNKKVSASSGDPQKYYGKELKIAKSLALIL
FLFALSWLPLHILNCITLFCPSCHKPSILTYIAIFLTHGNSAMNPIVYAFRIQKFRVTFL
KIWNDHFRCQPAPPIDEDLPEERPDD
Number of residues326
Molecular Weight36511.325
Theoretical pI8.75
GO Classification
Functions
    G-protein coupled adenosine receptor activity
    purine nucleoside binding
    phospholipase C activity
Processes
    positive regulation of blood pressure
    protein targeting to membrane
    negative regulation of glutamate secretion
    regulation of sensory perception of pain
    negative regulation of synaptic transmission, GABAergic
    positive regulation of nucleoside transport
    negative regulation of hormone secretion
    regulation of synaptic plasticity
    positive regulation of peptide secretion
    activation of MAPKK activity
    negative regulation of leukocyte migration
    temperature homeostasis
    adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway
    positive regulation of potassium ion transport
    negative regulation of apoptotic process
    negative regulation of lipid catabolic process
    negative regulation of blood pressure
    positive regulation of protein dephosphorylation
    signal transduction
    negative regulation of cell proliferation
    negative regulation of long term synaptic depression
    negative regulation of cardiac muscle contraction
    regulation of glomerular filtration
    response to hypoxia
    negative regulation of mucus secretion
    detection of temperature stimulus involved in sensory perception of pain
    negative regulation of neurotrophin production
    excitatory postsynaptic potential
    negative regulation of synaptic transmission, glutamatergic
    relaxation of vascular smooth muscle
    lipid catabolic process
    inflammatory response
    nervous system development
    negative regulation of vasodilation
    apoptotic signaling pathway
    negative regulation of acute inflammatory response
    phagocytosis
    negative regulation of renal sodium excretion
    cell-cell signaling
    negative regulation of circadian sleep/wake cycle, non-REM sleep
    regulation of respiratory gaseous exchange by neurological system process
    cognition
    positive regulation of epidermal growth factor-activated receptor activity
Components
    axolemma
    integral component of plasma membrane
    dendritic spine
    presynaptic active zone
    terminal bouton
    postsynaptic membrane
    neuronal cell body
    endoplasmic reticulum
    asymmetric synapse
    presynaptic membrane
    plasma membrane
    basolateral plasma membrane
    postsynaptic density
General FunctionPurine nucleoside binding
Specific FunctionReceptor for adenosine. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase.
Transmembrane Regions11-33 47-69 81-102 124-146 177-201 236-259 268-292
GenBank Protein ID256155
UniProtKB IDP30542
UniProtKB Entry NameAA1R_HUMAN
Cellular LocationCell membrane
Gene sequence
>lcl|BSEQ0010133|Adenosine receptor A1 (ADORA1)
ATGCCGCCCTCCATCTCAGCTTTCCAGGCCGCCTACATCGGCATCGAGGTGCTCATCGCC
CTGGTCTCTGTGCCCGGGAACGTGCTGGTGATCTGGGCGGTGAAGGTGAACCAGGCGCTG
CGGGATGCCACCTTCTGCTTCATCGTGTCGCTGGCGGTGGCTGATGTGGCCGTGGGTGCC
CTGGTCATCCCCCTCGCCATCCTCATCAACATTGGGCCACAGACCTACTTCCACACCTGC
CTCATGGTTGCCTGTCCGGTCCTCATCCTCACCCAGAGCTCCATCCTGGCCCTGCTGGCA
ATTGCTGTGGACCGCTACCTCCGGGTCAAGATCCCTCTCCGGTACAAGATGGTGGTGACC
CCCCGGAGGGCGGCGGTGGCCATAGCCGGCTGCTGGATCCTCTCCTTCGTGGTGGGACTG
ACCCCTATGTTTGGCTGGAACAATCTGAGTGCGGTGGAGCGGGCCTGGGCAGCCAACGGC
AGCATGGGGGAGCCCGTGATCAAGTGCGAGTTCGAGAAGGTCATCAGCATGGAGTACATG
GTCTACTTCAACTTCTTTGTGTGGGTGCTGCCCCCGCTTCTCCTCATGGTCCTCATCTAC
CTGGAGGTCTTCTACCTAATCCGCAAGCAGCTCAACAAGAAGGTGTCGGCCTCCTCCGGC
GACCCGCAGAAGTACTATGGGAAGGAGCTGAAGATCGCCAAGTCGCTGGCCCTCATCCTC
TTCCTCTTTGCCCTCAGCTGGCTGCCTTTGCACATCCTCAACTGCATCACCCTCTTCTGC
CCGTCCTGCCACAAGCCCAGCATCCTTACCTACATTGCCATCTTCCTCACGCACGGCAAC
TCGGCCATGAACCCCATTGTCTATGCCTTCCGCATCCAGAAGTTCCGCGTCACCTTCCTT
AAGATTTGGAATGACCATTTCCGCTGCCAGCCTGCACCTCCCATTGACGAGGATCTCCCA
GAAGAGAGGCCTGATGACTAG
GenBank Gene IDS45235
GeneCard IDNone
GenAtlas IDADORA1
HGNC IDHGNC:262
Chromosome Location1
Locus1q32.1
References
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  2. Townsend-Nicholson A, Shine J: Molecular cloning and characterisation of a human brain A1 adenosine receptor cDNA. Brain Res Mol Brain Res. 1992 Dec;16(3-4):365-70.[1339301 ]
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