Type-1 angiotensin II receptor
Name | Type-1 angiotensin II receptor |
---|---|
Synonyms | AGTR1A AGTR1B Angiotensin II type-1 receptor AT1 AT1AR AT1BR AT2R1 AT2R1B |
Gene Name | AGTR1 |
Organism | Human |
Amino acid sequence | >lcl|BSEQ0009910|Type-1 angiotensin II receptor MILNSSTEDGIKRIQDDCPKAGRHNYIFVMIPTLYSIIFVVGIFGNSLVVIVIYFYMKLK TVASVFLLNLALADLCFLLTLPLWAVYTAMEYRWPFGNYLCKIASASVSFNLYASVFLLT CLSIDRYLAIVHPMKSRLRRTMLVAKVTCIIIWLLAGLASLPAIIHRNVFFIENTNITVC AFHYESQNSTLPIGLGLTKNILGFLFPFLIILTSYTLIWKALKKAYEIQKNKPRNDDIFK IIMAIVLFFFFSWIPHQIFTFLDVLIQLGIIRDCRIADIVDTAMPITICIAYFNNCLNPL FYGFLGKKFKRYFLQLLKYIPPKAKSHSNLSTKMSTLSYRPSDNVSSSTKKPAPCFEVE |
Number of residues | 359 |
Molecular Weight | 41060.53 |
Theoretical pI | 9.71 |
GO Classification |
Functions
angiotensin type II receptor activity angiotensin type I receptor activity bradykinin receptor binding protein heterodimerization activity Processes
regulation of cell proliferation low-density lipoprotein particle remodeling regulation of inflammatory response phospholipase C-activating angiotensin-activated signaling pathway regulation of renal sodium excretion G-protein coupled receptor signaling pathway phospholipase C-activating G-protein coupled receptor signaling pathway regulation of systemic arterial blood pressure by renin-angiotensin positive regulation of reactive oxygen species metabolic process positive regulation of cellular protein metabolic process regulation of vasodilation positive regulation of cholesterol esterification renin-angiotensin regulation of aldosterone production positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway regulation of cell growth Rho protein signal transduction positive regulation of inflammatory response regulation of vasoconstriction angiotensin-activated signaling pathway positive regulation of macrophage derived foam cell differentiation calcium-mediated signaling positive regulation of NAD(P)H oxidase activity cell chemotaxis positive regulation of phospholipase A2 activity positive regulation of cytosolic calcium ion concentration kidney development regulation of blood vessel size by renin-angiotensin Components
integral component of plasma membrane intracellular plasma membrane integral component of membrane cytosol |
General Function | Protein heterodimerization activity |
Specific Function | Receptor for angiotensin II. Mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. |
Transmembrane Regions | 28-52 65-87 103-124 143-162 193-214 241-262 276-296 |
GenBank Protein ID | 179122 |
UniProtKB ID | P30556 |
UniProtKB Entry Name | AGTR1_HUMAN |
Cellular Location | Cell membrane |
Gene sequence | >lcl|BSEQ0009911|Type-1 angiotensin II receptor (AGTR1) ATGATTCTCAACTCTTCTACTGAAGATGGTATTAAAAGAATCCAAGATGATTGTCCCAAA GCTGGAAGGCATAATTACATATTTGTCATGATTCCTACTTTATACAGTATCATCTTTGTG GTGGGAATATTTGGAAACAGCTTGGTGGTGATAGTCATTTACTTTTATATGAAGCTGAAG ACTGTGGCCAGTGTTTTTCTTTTGAATTTAGCACTGGCTGACTTATGCTTTTTACTGACT TTGCCACTATGGGCTGTCTACACAGCTATGGAATACCGCTGGCCCTTTGGCAATTACCTA TGTAAGATTGCTTCAGCCAGCGTCAGTTTCAACCTGTACGCTAGTGTGTTTCTACTCACG TGTCTCAGCATTGATCGATACCTGGCTATTGTTCACCCAATGAAGTCCCGCCTTCGACGC ACAATGCTTGTAGCCAAAGTCACCTGCATCATCATTTGGCTGCTGGCAGGCTTGGCCAGT TTGCCAGCTATAATCCATCGAAATGTATTTTTCATTGAGAACACCAATATTACAGTTTGT GCTTTCCATTATGAGTCCCAAAATTCAACCCTCCCGATAGGGCTGGGCCTGACCAAAAAT ATACTGGGTTTCCTGTTTCCTTTTCTGATCATTCTTACAAGTTATACTCTTATTTGGAAG GCCCTAAAGAAGGCTTATGAAATTCAGAAGAACAAACCAAGAAATGATGATATTTTTAAG ATAATTATGGCAATTGTGCTTTTCTTTTTCTTTTCCTGGATTCCCCACCAAATATTCACT TTTCTGGATGTATTGATTCAACTAGGCATCATACGTGACTGTAGAATTGCAGATATTGTG GACACGGCCATGCCTATCACCATTTGTATAGCTTATTTTAACAATTGCCTGAATCCTCTT TTTTATGGCTTTCTGGGGAAAAAATTTAAAAGATATTTTCTCCAGCTTCTAAAATATATT CCCCCAAAAGCCAAATCCCACTCAAACCTTTCAACAAAAATGAGCACGCTTTCCTACCGC CCCTCAGATAATGTAAGCTCATCCACCAAGAAGCCTGCACCATGTTTTGAGGTTGAGTGA |
GenBank Gene ID | M91464 |
GeneCard ID | None |
GenAtlas ID | AGTR1 |
HGNC ID | HGNC:336 |
Chromosome Location | 3 |
Locus | 3q21-q25 |
References |
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Related FRC
FRCD ID | Name | Exact Mass | Structure |
---|---|---|---|
Mercuric chloride |
271.492 |