Mitogen-activated protein kinase 4

NameMitogen-activated protein kinase 4
Synonyms2.7.11.24 ERK-4 ERK4 Extracellular signal-regulated kinase 4 MAP kinase 4 MAP kinase isoform p63 p63-MAPK PRKM4
Gene NameMAPK4
OrganismHuman
Amino acid sequence
>lcl|BSEQ0008788|Mitogen-activated protein kinase 4
MAEKGDCIASVYGYDLGGRFVDFQPLGFGVNGLVLSAVDSRACRKVAVKKIALSDARSMK
HALREIKIIRRLDHDNIVKVYEVLGPKGTDLQGELFKFSVAYIVQEYMETDLARLLEQGT
LAEEHAKLFMYQLLRGLKYIHSANVLHRDLKPANIFISTEDLVLKIGDFGLARIVDQHYS
HKGYLSEGLVTKWYRSPRLLLSPNNYTKAIDMWAAGCILAEMLTGRMLFAGAHELEQMQL
ILETIPVIREEDKDELLRVMPSFVSSTWEVKRPLRKLLPEVNSEAIDFLEKILTFNPMDR
LTAEMGLQHPYMSPYSCPEDEPTSQHPFRIEDEIDDIVLMAANQSQLSNWDTCSSRYPVS
LSSDLEWRPDRCQDASEVQRDPRAGSAPLAEDVQVDPRKDSHSSSERFLEQSHSSMERAF
EADYGRSCDYKVGSPSYLDKLLWRDNKPHHYSEPKLILDLSHWKQAAGAPPTATGLADTG
AREDEPASLFLEIAQWVKSTQGGPEHASPPADDPERRLSASPPGRPAPVDGGASPQFDLD
VFISRALKLCTKPEDLPDNKLGDLNGACIPEHPGDLVQTEAFSKERW
Number of residues587
Molecular Weight65921.01
Theoretical pINone
GO Classification
Functions
    MAP kinase activity
protein homodimerization activity
protein kinase binding
ATP binding
protein serine/threonine kinase activity
Processes
    cell cycle
MAPK cascade
protein phosphorylation
Components
    cytosol
nucleoplasm
cytoplasm
nucleus
General FunctionProtein serine/threonine kinase activity
Specific FunctionAtypical MAPK protein. Phosphorylates microtubule-associated protein 2 (MAP2) and MAPKAPK5. The precise role of the complex formed with MAPKAPK5 is still unclear, but the complex follows a complex set of phosphorylation events: upon interaction with atypical MAPKAPK5, ERK4/MAPK4 is phosphorylated at Ser-186 and then mediates phosphorylation and activation of MAPKAPK5, which in turn phosphorylates ERK4/MAPK4. May promote entry in the cell cycle (By similarity).
Transmembrane Regions
GenBank Protein ID
UniProtKB IDP31152
UniProtKB Entry NameMK04_HUMAN
Cellular LocationCytoplasm
Gene sequence
>lcl|BSEQ0013414|Mitogen-activated protein kinase 4 (MAPK4)
ATGTGGGCCGCCGGCTGCATCCTGGCTGAGATGCTTACGGGGAGAATGCTCTTTGCTGGG
GCCCATGAGCTGGAGCAGATGCAACTCATCCTGGAGACCATCCCTGTAATCCGGGAGGAA
GACAAGGACGAGCTGCTCAGGGTGATGCCTTCCTTTGTCAGCAGCACCTGGGAGGTGAAG
AGGCCTCTGCGCAAGCTGCTCCCTGAAGTGAACAGTGAAGCCATCGACTTTCTGGAGAAG
ATCCTGACCTTTAACCCCATGGATCGCCTAACAGCTGAGATGGGGCTGCAACACCCCTAC
ATGAGCCCATACTCGTGCCCTGAGGACGAGCCCACCTCACAACACCCCTTCCGCATTGAG
GATGAGATCGACGACATCGTGCTGATGGCCGCTAACCAGAGCCAGCTGTCCAACTGGGAC
ACGTGCAGTTCCAGGTACCCTGTGAGCCTGTCGTCGGACCTGGAGTGGCGGCCTGACCGG
TGCCAGGACGCCAGCGAGGTACAGCGCGACCCGCGCGCGGGTTCGGCGCCACTGGCTGAG
GACGTGCAGGTGGACCCGCGCAAGGACTCGCACAGCAGCTCCGAGCGCTTCCTAGAGCAG
TCGCACTCGTCCATGGAGCGCGCCTTCGAGGCCGACTACGGGCGCTCCTGCGACTACAAG
GTGGGGTCGCCGTCCTACCTGGACAAGCTGCTGTGGCGCGACAACAAGCCGCACCACTAC
TCGGAGCCCAAGCTCATCCTGGACCTGTCGCACTGGAAGCAGGCGGCCGGCGCGCCCCCC
ACGGCCACGGGGCTGGCGGACACGGGGGCGCGCGAGGACGAGCCGGCCAGCCTCTTCCTG
GAGATCGCGCAGTGGGTCAAGAGCACGCAGGGCGGCCCAGAGCACGCCAGCCCGCCCGCC
GACGACCCCGAGCGCCGCTTGTCTGCCTCGCCCCCCGGCCGCCCGGCCCCGGTGGACGGC
GGCGCCAGCCCCCAGTTCGACCTGGACGTGTTCATCTCCCGCGCCCTGAAGCTCTGCACC
AAGCCCGAGGACCTGCCGGACAATAAACTGGGCGACCTCAATGGTGCGTGCATCCCCGAG
CACCCTGGCGACCTCGTGCAGACCGAGGCCTTCTCCAAAGAAAGGTGGTGA
GenBank Gene ID
GeneCard IDNone
GenAtlas ID
HGNC IDHGNC:6878
Chromosome Location18
LocusNone
References
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  3. Dephoure N, Zhou C, Villen J, Beausoleil SA, Bakalarski CE, Elledge SJ, Gygi SP: A quantitative atlas of mitotic phosphorylation. Proc Natl Acad Sci U S A. 2008 Aug 5;105(31):10762-7. doi: 10.1073/pnas.0805139105. Epub 2008 Jul 31.[18669648 ]
  4. Deleris P, Trost M, Topisirovic I, Tanguay PL, Borden KL, Thibault P, Meloche S: Activation loop phosphorylation of ERK3/ERK4 by group I p21-activated kinases (PAKs) defines a novel PAK-ERK3/4-MAPK-activated protein kinase 5 signaling pathway. J Biol Chem. 2011 Feb 25;286(8):6470-8. doi: 10.1074/jbc.M110.181529. Epub 2010 Dec 22.[21177870 ]
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