Gamma-aminobutyric acid receptor subunit alpha-5
Name | Gamma-aminobutyric acid receptor subunit alpha-5 |
---|---|
Synonyms | GABA(A) receptor subunit alpha-5 |
Gene Name | GABRA5 |
Organism | Human |
Amino acid sequence | >lcl|BSEQ0010331|Gamma-aminobutyric acid receptor subunit alpha-5 MDNGMFSGFIMIKNLLLFCISMNLSSHFGFSQMPTSSVKDETNDNITIFTRILDGLLDGY DNRLRPGLGERITQVRTDIYVTSFGPVSDTEMEYTIDVFFRQSWKDERLRFKGPMQRLPL NNLLASKIWTPDTFFHNGKKSIAHNMTTPNKLLRLEDDGTLLYTMRLTISAECPMQLEDF PMDAHACPLKFGSYAYPNSEVVYVWTNGSTKSVVVAEDGSRLNQYHLMGQTVGTENISTS TGEYTIMTAHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTM TTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGWAWDGKKALEAA KIKKKREVILNKSTNAFTTGKMSHPPNIPKEQTPAGTSNTTSVSVKPSEEKTSESKKTYN SISKIDKMSRIVFPVLFGTFNLVYWATYLNREPVIKGAASPK |
Number of residues | 462 |
Molecular Weight | 52145.645 |
Theoretical pI | 9.56 |
GO Classification |
Functions
inhibitory extracellular ligand-gated ion channel activity transporter activity receptor activity chloride channel activity GABA-A receptor activity Processes
gamma-aminobutyric acid signaling pathway chloride transmembrane transport associative learning synaptic transmission brain development behavioral fear response cochlea development transport negative regulation of neuron apoptotic process inner ear receptor cell development transmembrane transport regulation of membrane potential signal transduction innervation sensory perception of sound positive regulation of defense response to virus by host ion transmembrane transport xenophagy mitophagy in response to mitochondrial depolarization response to drug neurological system process Components
GABA-A receptor complex plasma membrane cell junction neuronal cell body membrane integral component of plasma membrane postsynaptic membrane dendrite synapse neuron projection chloride channel complex |
General Function | Transporter activity |
Specific Function | GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel. |
Transmembrane Regions | 260-281 286-307 319-341 428-449 |
GenBank Protein ID | 182916 |
UniProtKB ID | P31644 |
UniProtKB Entry Name | GBRA5_HUMAN |
Cellular Location | Cell junction |
Gene sequence | >lcl|BSEQ0010332|Gamma-aminobutyric acid receptor subunit alpha-5 (GABRA5) ATGGACAATGGAATGTTCTCTGGTTTTATCATGATCAAAAACCTCCTTCTCTTTTGTATT TCCATGAACTTATCCAGTCACTTTGGCTTTTCACAGATGCCAACCAGTTCAGTGAAAGAT GAGACCAATGACAACATCACGATATTTACCAGGATCTTGGATGGGCTCTTGGATGGCTAC GACAACAGACTTCGGCCCGGGCTGGGAGAGCGCATCACTCAGGTGAGGACCGACATCTAC GTCACCAGCTTCGGCCCGGTGTCCGACACGGAAATGGAGTACACCATAGACGTGTTTTTC CGACAAAGCTGGAAAGATGAAAGGCTTCGGTTTAAGGGGCCCATGCAGCGCCTCCCTCTC AACAACCTCCTTGCCAGCAAGATCTGGACCCCAGACACGTTCTTCCACAACGGGAAGAAG TCCATCGCTCACAACATGACCACGCCCAACAAGCTGCTGCGGCTGGAGGACGACGGCACC CTGCTCTACACCATGCGCTTGACCATCTCTGCAGAGTGCCCCATGCAGCTTGAGGACTTC CCGATGGATGCGCACGCTTGCCCTCTGAAATTTGGCAGCTATGCGTACCCTAATTCTGAA GTCGTTTACGTCTGGACCAACGGCTCCACCAAGTCGGTGGTGGTGGCGGAAGATGGCTCC AGACTGAACCAGTACCACCTGATGGGGCAGACGGTGGGCACTGAGAACATCAGCACCAGC ACAGGCGAATACACAATCATGACAGCTCACTTCCACCTGAAAAGGAAGATTGGCTACTTT GTCATCCAGACCTACCTTCCCTGCATAATGACCGTGATCTTATCACAGGTGTCCTTTTGG CTGAACCGGGAATCAGTCCCAGCCAGGACAGTTTTTGGGGTCACCACGGTGCTGACCATG ACGACCCTCAGCATCAGCGCCAGGAACTCTCTGCCCAAAGTGGCCTACGCCACCGCCATG GACTGGTTCATAGCCGTGTGCTATGCCTTCGTCTTCTCGGCGCTGATAGAGTTTGCCACG GTCAATTACTTTACCAAGAGAGGCTGGGCCTGGGATGGCAAAAAAGCCTTGGAAGCAGCC AAGATCAAGAAAAAGCGTGAAGTCATACTAAATAAGTCAACAAACGCTTTTACAACTGGG AAGATGTCTCACCCCCCAAACATTCCGAAGGAACAGACCCCAGCAGGGACGTCGAATACA ACCTCAGTCTCAGTAAAACCCTCTGAAGAGAAGACTTCTGAAAGCAAAAAGACTTACAAC AGTATCAGCAAAATTGACAAAATGTCCCGAATCGTATTCCCAGTCTTGTTCGGCACTTTC AACTTAGTTTACTGGGCAACGTATTTGAATAGGGAGCCGGTGATAAAAGGAGCCGCCTCT CCAAAATAA |
GenBank Gene ID | L08485 |
GeneCard ID | None |
GenAtlas ID | GABRA5 |
HGNC ID | HGNC:4079 |
Chromosome Location | 15 |
Locus | 15q11.2-q12 |
References |
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