Cholecystokinin receptor type A
Name | Cholecystokinin receptor type A |
---|---|
Synonyms | CCK-A receptor CCK1-R CCKRA Cholecystokinin-1 receptor |
Gene Name | CCKAR |
Organism | Human |
Amino acid sequence | >lcl|BSEQ0010278|Cholecystokinin receptor type A MDVVDSLLVNGSNITPPCELGLENETLFCLDQPRPSKEWQPAVQILLYSLIFLLSVLGNT LVITVLIRNKRMRTVTNIFLLSLAVSDLMLCLFCMPFNLIPNLLKDFIFGSAVCKTTTYF MGTSVSVSTFNLVAISLERYGAICKPLQSRVWQTKSHALKVIAATWCLSFTIMTPYPIYS NLVPFTKNNNQTANMCRFLLPNDVMQQSWHTFLLLILFLIPGIVMMVAYGLISLELYQGI KFEASQKKSAKERKPSTTSSGKYEDSDGCYLQKTRPPRKLELRQLSTGSSSRANRIRSNS SAANLMAKKRVIRMLIVIVVLFFLCWMPIFSANAWRAYDTASAERRLSGTPISFILLLSY TSSCVNPIIYCFMNKRFRLGFMATFPCCPNPGPPGARGEVGEEEEGGTTGASLSRFSYSH MSASVPPQ |
Number of residues | 428 |
Molecular Weight | 47840.645 |
Theoretical pI | 9.48 |
GO Classification |
Functions
peptide binding cholecystokinin receptor activity Processes
actin cytoskeleton reorganization digestion axonogenesis cholecystokinin signaling pathway response to peptide feeding behavior positive regulation of cytosolic calcium ion concentration response to nutrient insulin secretion forebrain development neuron migration phospholipase C-activating G-protein coupled receptor signaling pathway response to starvation pancreas development response to glucocorticoid pancreatic juice secretion temperature homeostasis positive regulation of somatostatin secretion response to heat reduction of food intake in response to dietary excess cellular response to hormone stimulus gastric acid secretion regulation of hormone secretion response to lipopolysaccharide organ regeneration response to radiation regulation of potassium ion transport regulation of calcium ion transport Components
cytosol integral component of plasma membrane terminal bouton endoplasmic reticulum endosome plasma membrane lysosome |
General Function | Peptide binding |
Specific Function | Receptor for cholecystokinin. Mediates pancreatic growth and enzyme secretion, smooth muscle contraction of the gall bladder and stomach. Has a 1000-fold higher affinity for CCK rather than for gastrin. It modulates feeding and dopamine-induced behavior in the central and peripheral nervous system. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. |
Transmembrane Regions | 42-67 78-104 116-137 158-178 211-234 314-334 350-373 |
GenBank Protein ID | 306491 |
UniProtKB ID | P32238 |
UniProtKB Entry Name | CCKAR_HUMAN |
Cellular Location | Cell membrane |
Gene sequence | >lcl|BSEQ0010279|Cholecystokinin receptor type A (CCKAR) ATGGATGTGGTTGACAGCCTTCTTGTGAATGGAAGCAACATCACTCCTCCCTGTGAACTC GGGCTCGAAAATGAGACGCTTTTCTGCTTGGATCAGCCCCGTCCTTCCAAAGAGTGGCAG CCAGCGGTGCAGATTCTCTTGTACTCCTTGATATTCCTGCTCAGCGTGCTGGGAAACACG CTGGTCATCACCGTGCTGATTCGGAACAAGCGGATGCGGACGGTCACCAACATCTTCCTC CTCTCCCTGGCTGTCAGCGACCTCATGCTCTGTCTCTTCTGCATGCCGTTCAACCTCATC CCCAATCTGCTCAAGGATTTCATCTTCGGGAGCGCCGTTTGCAAGACCACCACCTACTTC ATGGGCACCTCTGTGAGTGTATCTACCTTTAATCTGGTAGCCATATCTCTAGAGAGATAT GGTGCGATTTGCAAACCCTTACAGTCCCGGGTCTGGCAGACAAAATCCCATGCTTTGAAG GTGATTGCTGCTACCTGGTGCCTTTCCTTTACCATCATGACTCCGTACCCCATTTATAGC AACTTGGTGCCTTTTACCAAAAATAACAACCAGACCGCGAATATGTGCCGCTTTCTACTG CCAAATGATGTTATGCAGCAGTCCTGGCACACATTCCTGTTACTCATCCTCTTTCTTATT CCTGGAATTGTGATGATGGTGGCATATGGATTAATCTCTTTGGAACTCTACCAGGGAATA AAATTTGAGGCTAGCCAGAAGAAGTCTGCTAAAGAAAGGAAACCTAGCACCACCAGCAGC GGCAAATATGAGGACAGCGATGGGTGTTACCTGCAAAAGACCAGGCCCCCGAGGAAGCTG GAGCTCCGGCAGCTGTCCACCGGCAGCAGCAGCAGGGCCAACCGCATCCGGAGTAACAGC TCCGCAGCCAACCTGATGGCCAAGAAAAGGGTGATCCGCATGCTCATCGTCATCGTGGTC CTCTTCTTCCTGTGCTGGATGCCCATCTTCAGCGCCAACGCCTGGCGGGCCTACGACACC GCCTCCGCAGAGCGCCGCCTCTCAGGAACCCCCATTTCCTTCATCCTCCTCCTGTCCTAC ACCTCCTCCTGCGTCAACCCCATCATCTACTGCTTCATGAACAAACGCTTCCGCCTCGGC TTCATGGCCACCTTCCCCTGCTGCCCCAATCCTGGTCCCCCAGGGGCGAGGGGAGAGGTG GGGGAGGAGGAGGAAGGCGGGACCACAGGAGCCTCTCTGTCCAGGTTCTCGTACAGCCAT ATGAGTGCCTCGGTGCCACCCCAGTGA |
GenBank Gene ID | L13605 |
GeneCard ID | None |
GenAtlas ID | CCKAR |
HGNC ID | HGNC:1570 |
Chromosome Location | 4 |
Locus | 4p15.1-p15.2 |
References |
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Related FRC
FRCD ID | Name | Exact Mass | Structure |
---|---|---|---|
Diazepam |
284.74 |