Neuronal acetylcholine receptor subunit alpha-3
Name | Neuronal acetylcholine receptor subunit alpha-3 |
---|---|
Synonyms | NACHRA3 |
Gene Name | CHRNA3 |
Organism | Human |
Amino acid sequence | >lcl|BSEQ0006903|Neuronal acetylcholine receptor subunit alpha-3 MGSGPLSLPLALSPPRLLLLLLLSLLPVARASEAEHRLFERLFEDYNEIIRPVANVSDPV IIHFEVSMSQLVKVDEVNQIMETNLWLKQIWNDYKLKWNPSDYGGAEFMRVPAQKIWKPD IVLYNNAVGDFQVDDKTKALLKYTGEVTWIPPAIFKSSCKIDVTYFPFDYQNCTMKFGSW SYDKAKIDLVLIGSSMNLKDYWESGEWAIIKAPGYKHDIKYNCCEEIYPDITYSLYIRRL PLFYTINLIIPCLLISFLTVLVFYLPSDCGEKVTLCISVLLSLTVFLLVITETIPSTSLV IPLIGEYLLFTMIFVTLSIVITVFVLNVHYRTPTTHTMPSWVKTVFLNLLPRVMFMTRPT SNEGNAQKPRPLYGAELSNLNCFSRAESKGCKEGYPCQDGMCGYCHHRRIKISNFSANLT RSSSSESVDAVLSLSALSPEIKEAIQSVKYIAENMKAQNEAKEIQDDWKYVAMVIDRIFL WVFTLVCILGTAGLFLQPLMAREDA |
Number of residues | 505 |
Molecular Weight | 57479.54 |
Theoretical pI | 6.4 |
GO Classification |
Functions
acetylcholine receptor activity drug binding ligand-gated ion channel activity acetylcholine binding acetylcholine-activated cation-selective channel activity Processes
regulation of smooth muscle contraction heart development protein heterooligomerization behavioral response to nicotine ion transmembrane transport activation of transmembrane receptor protein tyrosine kinase activity ion transport regulation of dendrite morphogenesis regulation of membrane potential signal transduction synaptic transmission involved in micturition excitatory postsynaptic potential response to inorganic substance cation transmembrane transport nervous system development neurological system process response to drug synaptic transmission, cholinergic regulation of acetylcholine secretion, neurotransmission locomotory behavior synaptic transmission Components
cell junction postsynaptic density integral component of membrane neuronal cell body dendrite synapse postsynaptic membrane plasma membrane acetylcholine-gated channel complex neuron projection |
General Function | Ligand-gated ion channel activity |
Specific Function | After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. |
Transmembrane Regions | 241-265 273-291 307-328 478-497 |
GenBank Protein ID | 177898 |
UniProtKB ID | P32297 |
UniProtKB Entry Name | ACHA3_HUMAN |
Cellular Location | Cell junction |
Gene sequence | >lcl|BSEQ0012491|Neuronal acetylcholine receptor subunit alpha-3 (CHRNA3) ATGGGCTCTGGCCCGCTCTCGCTGCCCCTGGCGCTGTCGCCGCCGCGGCTGCTGCTGCTG CTGCTGCTGTCTCTGCTGCCAGTGGCCAGGGCCTCAGAGGCTGAGCACCGTCTATTTGAG CGGCTGTTTGAAGATTACAATGAGATCATCCGGCCTGTAGCCAACGTGTCTGACCCAGTC ATCATCCATTTCGAGGTGTCCATGTCTCAGCTGGTGAAGGTGGATGAAGTAAACCAGATC ATGGAGACCAACCTGTGGCTCAAGCAAATCTGGAATGACTACAAGCTGAAATGGAACCCC TCTGACTATGGTGGGGCAGAGTTCATGCGTGTCCCTGCACAGAAGATCTGGAAGCCAGAC ATTGTGCTGTATAACAATGCTGTTGGGGATTTCCAGGTGGACGACAAGACCAAAGCCTTA CTCAAGTACACTGGGGAGGTGACTTGGATACCTCCGGCCATCTTTAAGAGCTCCTGTAAA ATCGACGTGACCTACTTCCCGTTTGATTACCAAAACTGTACCATGAAGTTCGGTTCCTGG TCCTACGATAAGGCGAAAATCGATCTGGTCCTGATCGGCTCTTCCATGAACCTCAAGGAC TATTGGGAGAGCGGCGAGTGGGCCATCATCAAAGCCCCAGGCTACAAACACGACATCAAG TACAACTGCTGCGAGGAGATCTACCCCGACATCACATACTCGCTGTACATCCGGCGCCTG CCCTTGTTCTACACCATCAACCTCATCATCCCCTGCCTGCTCATCTCCTTCCTCACTGTG CTCGTCTTCTACCTGCCCTCCGACTGCGGTGAGAAGGTGACCCTGTGCATTTCTGTCCTC CTCTCCCTGACGGTGTTTCTCCTGGTGATCACTGAGACCATCCCTTCCACCTCGCTGGTC ATCCCCCTGATTGGAGAGTACCTCCTGTTCACCATGATTTTTGTAACCTTGTCCATCGTC ATCACCGTCTTCGTGCTCAACGTGCACTACAGAACCCCGACGACACACACAATGCCCTCA TGGGTGAAGACTGTATTCTTGAACCTGCTCCCCAGGGTCATGTTCATGACCAGGCCAACA AGCAACGAGGGCAACGCTCAGAAGCCGAGGCCCCTCTACGGTGCCGAGCTCTCAAATCTG AATTGCTTCAGCCGCGCAGAGTCCAAAGGCTGCAAGGAGGGCTACCCCTGCCAGGACGGG ATGTGTGGTTACTGCCACCACCGCAGGATAAAAATCTCCAATTTCAGTGCTAACCTCACG AGAAGCTCTAGTTCTGAATCTGTTGATGCTGTGCTGTCCCTCTCTGCTTTGTCACCAGAA ATCAAAGAAGCCATCCAAAGTGTCAAGTATATTGCTGAAAATATGAAAGCACAAAATGAA GCCAAAGAGATTCAAGATGATTGGAAGTATGTTGCCATGGTGATTGATCGTATTTTTCTG TGGGTTTTCACCCTGGTGTGCATTCTAGGGACAGCAGGATTGTTTCTGCAACCCCTGATG GCCAGGGAAGATGCATAA |
GenBank Gene ID | M86383 |
GeneCard ID | None |
GenAtlas ID | |
HGNC ID | HGNC:1957 |
Chromosome Location | 15 |
Locus | 15q24 |
References |
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