Sodium/calcium exchanger 1


NameSodium/calcium exchanger 1
SynonymsCNC Na(+)/Ca(2+)-exchange protein 1 NCX1 Solute carrier family 8 member 1
Gene NameSLC8A1
OrganismHuman
Amino acid sequence
>lcl|BSEQ0001963|Sodium/calcium exchanger 1
MYNMRRLSLSPTFSMGFHLLVTVSLLFSHVDHVIAETEMEGEGNETGECTGSYYCKKGVI
LPIWEPQDPSFGDKIARATVYFVAMVYMFLGVSIIADRFMSSIEVITSQEKEITIKKPNG
ETTKTTVRIWNETVSNLTLMALGSSAPEILLSVIEVCGHNFTAGDLGPSTIVGSAAFNMF
IIIALCVYVVPDGETRKIKHLRVFFVTAAWSIFAYTWLYIILSVISPGVVEVWEGLLTFF
FFPICVVFAWVADRRLLFYKYVYKRYRAGKQRGMIIEHEGDRPSSKTEIEMDGKVVNSHV
ENFLDGALVLEVDERDQDDEEARREMARILKELKQKHPDKEIEQLIELANYQVLSQQQKS
RAFYRIQATRLMTGAGNILKRHAADQARKAVSMHEVNTEVTENDPVSKIFFEQGTYQCLE
NCGTVALTIIRRGGDLTNTVFVDFRTEDGTANAGSDYEFTEGTVVFKPGDTQKEIRVGII
DDDIFEEDENFLVHLSNVKVSSEASEDGILEANHVSTLACLGSPSTATVTIFDDDHAGIF
TFEEPVTHVSESIGIMEVKVLRTSGARGNVIVPYKTIEGTARGGGEDFEDTCGELEFQND
EIVKTISVKVIDDEEYEKNKTFFLEIGEPRLVEMSEKKALLLNELGGFTITGKYLFGQPV
FRKVHAREHPILSTVITIADEYDDKQPLTSKEEEERRIAEMGRPILGEHTKLEVIIEESY
EFKSTVDKLIKKTNLALVVGTNSWREQFIEAITVSAGEDDDDDECGEEKLPSCFDYVMHF
LTVFWKVLFAFVPPTEYWNGWACFIVSILMIGLLTAFIGDLASHFGCTIGLKDSVTAVVF
VALGTSVPDTFASKVAATQDQYADASIGNVTGSNAVNVFLGIGVAWSIAAIYHAANGEQF
KVSPGTLAFSVTLFTIFAFINVGVLLYRRRPEIGGELGGPRTAKLLTSCLFVLLWLLYIF
FSSLEAYCHIKGF
Number of residues973
Molecular Weight108546.06
Theoretical pI4.64
GO Classification
Functions
    cytoskeletal protein binding
    calcium
    calcium ion binding
    ankyrin binding
    ion channel binding
Processes
    regulation of cell communication by electrical coupling
    negative regulation of cytosolic calcium ion concentration
    muscle fiber development
    positive regulation of fibroblast migration
    regulation of heart rate
    relaxation of smooth muscle
    cellular sodium ion homeostasis
    telencephalon development
    regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
    cellular response to hypoxia
    sodium ion import
    calcium ion import
    relaxation of cardiac muscle
    cellular response to caffeine
    response to nutrient
    vascular smooth muscle contraction
    sodium ion transmembrane transport
    calcium ion transport into cytosol
    positive regulation of the force of heart contraction
    ion transport
    positive regulation of bone mineralization
    transmembrane transport
    embryonic placenta development
    regulation of cardiac muscle contraction by calcium ion signaling
    muscle contraction
    response to hydrogen peroxide
    heart morphogenesis
    blood coagulation
    post-embryonic development
    regulation of the force of heart contraction
    sodium ion export
    regulation of sodium ion transport
    response to muscle stretch
    embryonic heart tube development
    cellular response to reactive oxygen species
    response to drug
    response to ATP
    cell communication by electrical coupling involved in cardiac conduction
    calcium ion export
    response to glucose
    calcium ion transmembrane transport
    cardiac muscle contraction
    cytosolic calcium ion transport
    calcium ion homeostasis
    cellular response to cAMP
    response to immobilization stress
    cardiac muscle cell development
    membrane depolarization during cardiac muscle cell action potential
Components
    cytosol
    integral component of plasma membrane
    mitochondrion
    intercalated disc
    sarcolemma
    microtubule
    T-tubule
    dendritic spine
    Z disc
    basolateral plasma membrane
    plasma membrane
    dendritic shaft
General FunctionIon channel binding
Specific FunctionMediates the exchange of one Ca(2+) ion against three to four Na(+) ions across the cell membrane, and thereby contributes to the regulation of cytoplasmic Ca(2+) levels and Ca(2+)-dependent cellular processes (PubMed:1374913, PubMed:11241183, PubMed:1476165). Contributes to Ca(2+) transport during excitation-contraction coupling in muscle. In a first phase, voltage-gated channels mediate the rapid increase of cytoplasmic Ca(2+) levels due to release of Ca(2+) stores from the endoplasmic reticulum. SLC8A1 mediates the export of Ca(2+) from the cell during the next phase, so that cytoplasmic Ca(2+) levels rapidly return to baseline. Required for normal embryonic heart development and the onset of heart contractions.
Transmembrane Regions75-95 137-157 171-191 205-225 232-252 801-821 825-845 875-895 907-927 945-965
GenBank Protein ID180673
UniProtKB IDP32418
UniProtKB Entry NameNAC1_HUMAN
Cellular LocationCell membrane
Gene sequence
>lcl|BSEQ0016275|Sodium/calcium exchanger 1 (SLC8A1)
ATGTACAACATGCGGCGATTAAGTCTTTCACCCACCTTTTCAATGGGATTTCATCTGTTA
GTTACTGTGAGTCTCTTATTTTCCCATGTGGACCATGTAATTGCTGAGACAGAAATGGAA
GGAGAAGGAAATGAAACTGGTGAATGTACTGGATCATATTACTGTAAGAAAGGGGTGATT
TTGCCCATTTGGGAACCCCAAGACCCTTCTTTTGGGGACAAAATTGCTAGAGCTACTGTG
TATTTTGTGGCCATGGTCTACATGTTTCTTGGAGTCTCTATCATAGCTGATCGGTTCATG
TCCTCTATAGAAGTCATCACATCTCAAGAAAAAGAAATAACCATAAAGAAACCCAATGGA
GAGACCACCAAGACAACTGTGAGGATCTGGAATGAAACAGTTTCTAACCTGACCTTGATG
GCCCTGGGATCTTCTGCTCCTGAGATTCTCCTTTCAGTAATTGAAGTGTGTGGCCATAAC
TTCACTGCAGGAGACCTCGGTCCTAGCACCATCGTGGGAAGTGCTGCATTCAATATGTTC
ATCATTATTGCACTCTGTGTTTATGTGGTGCCTGACGGAGAGACAAGGAAGATTAAGCAT
TTGCGTGTCTTCTTTGTGACAGCAGCCTGGAGCATCTTTGCCTACACCTGGCTTTACATT
ATTTTGTCTGTCATATCTCCTGGTGTTGTGGAGGTCTGGGAAGGTTTGCTTACTTTCTTC
TTCTTTCCCATCTGTGTTGTGTTCGCTTGGGTAGCGGATAGGAGACTTCTGTTTTACAAG
TATGTCTACAAGAGGTATCGAGCTGGCAAGCAGAGGGGGATGATTATTGAACATGAAGGA
GACAGGCCATCTTCTAAGACTGAAATTGAAATGGACGGGAAAGTGGTCAATTCTCATGTT
GAAAATTTCTTAGATGGTGCTCTGGTTCTGGAGGTGGATGAGAGGGACCAAGATGATGAA
GAAGCTAGGCGAGAAATGGCTAGGATTCTGAAGGAACTTAAGCAGAAGCATCCAGATAAA
GAAATAGAGCAATTAATAGAATTAGCTAACTACCAAGTCCTAAGTCAGCAGCAAAAAAGT
AGAGCATTTTATCGCATTCAAGCTACTCGCCTCATGACTGGAGCTGGCAACATTTTAAAG
AGGCATGCAGCTGACCAAGCAAGGAAGGCTGTCAGCATGCACGAGGTCAACACTGAAGTG
ACTGAAAATGACCCTGTTAGTAAGATCTTCTTTGAACAAGGGACATATCAGTGTCTGGAG
AACTGTGGTACTGTGGCCCTTACCATTATCCGCAGAGGTGGTGATTTGACTAACACTGTG
TTTGTTGACTTCAGAACAGAGGATGGCACAGCAAATGCTGGGTCTGATTATGAATTTACT
GAAGGAACTGTGGTGTTTAAGCCTGGTGATACCCAGAAGGAAATCAGAGTGGGTATCATA
GATGATGATATCTTTGAGGAGGATGAAAATTTCCTTGTGCATCTCAGCAATGTCAAAGTA
TCTTCTGAAGCTTCAGAAGATGGCATACTGGAAGCCAATCATGTTTCTACACTTGCTTGC
CTCGGATCTCCCTCCACTGCCACTGTAACTATTTTTGATGATGACCACGCAGGCATTTTT
ACTTTTGAGGAACCTGTGACTCATGTGAGTGAGAGCATTGGCATCATGGAGGTGAAAGTA
TTGAGAACATCTGGAGCTCGAGGAAATGTTATCGTTCCATATAAAACCATCGAAGGGACT
GCCAGAGGTGGAGGGGAGGATTTTGAGGACACTTGTGGAGAGCTCGAATTCCAGAATGAT
GAAATTGTCAAAACAATATCAGTCAAGGTAATTGATGATGAGGAGTATGAGAAAAACAAG
ACCTTCTTCCTTGAGATTGGAGAGCCCCGCCTGGTGGAGATGAGTGAGAAGAAAGCCCTG
TTATTGAATGAGCTTGGTGGCTTCACAATAACAGGCCAACCTGTCTTCAGGAAGGTTCAT
GCTAGAGAACATCCGATTCTCTCTACTGTAATCACCATTGCAGACGAATATGATGACAAG
CAGCCACTGACCAGCAAAGAGGAAGAGGAGAGGCGCATTGCAGAAATGGGGCGCCCCATC
CTGGGAGAGCACACCAAGTTGGAAGTGATCATTGAAGAATCCTATGAATTCAAGAGTACT
GTGGACAAACTCATTAAGAAGACAAACCTGGCCCTTGTGGTTGGGACTAACAGCTGGAGA
GAACAGTTCATTGAAGCTATCACTGTCAGTGCTGGGGAAGATGATGACGACGATGAATGT
GGGGAAGAGAAGCTGCCCTCCTGTTTCGATTACGTGATGCACTTTCTGACTGTGTTCTGG
AAGGTCCTGTTTGCCTTCGTCCCCCCTACTGAATACTGGAATGGCTGGGCGTGTTTCATT
GTCTCCATCCTCATGATTGGCCTACTGACAGCTTTCATTGGAGACCTGGCTTCCCACTTT
GGCTGCACCATTGGCCTGAAAGATTCTGTGACTGCAGTCGTGTTCGTCGCACTTGGAACA
TCAGTGCCAGACACATTTGCCAGCAAAGTGGCAGCCACCCAGGACCAGTATGCAGACGCC
TCCATAGGTAACGTCACGGGCAGCAACGCGGTGAATGTCTTCCTGGGAATCGGTGTGGCC
TGGTCCATCGCTGCCATCTACCACGCAGCCAATGGGGAACAGTTCAAAGTGTCCCCTGGC
ACACTAGCTTTCTCTGTCACTCTCTTCACCATTTTTGCTTTCATCAATGTGGGGGTGCTG
CTGTATCGGCGGAGGCCAGAAATCGGAGGTGAGCTGGGTGGGCCCCGGACTGCCAAGCTC
CTCACATCCTGCCTCTTTGTGCTCCTATGGCTCTTGTACATTTTCTTCTCCTCCCTGGAG
GCCTACTGCCACATAAAAGGCTTCTAA
GenBank Gene IDM91368
GeneCard IDNone
GenAtlas IDSLC8A1
HGNC IDHGNC:11068
Chromosome Location2
Locus2p23-p22
References
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  2. Komuro I, Wenninger KE, Philipson KD, Izumo S: Molecular cloning and characterization of the human cardiac Na+/Ca2+ exchanger cDNA. Proc Natl Acad Sci U S A. 1992 May 15;89(10):4769-73.[1374913 ]
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  4. Lundquist P, Lundgren T, Gritli-Linde A, Linde A: Na+/Ca2+ exchanger isoforms of rat odontoblasts and osteoblasts. Calcif Tissue Int. 2000 Jul;67(1):60-7.[10908415 ]
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  6. Loo TW, Clarke DM: Functional expression of human renal Na+/Ca2+ exchanger in insect cells. Am J Physiol. 1994 Jul;267(1 Pt 2):F70-4.[8048567 ]
  7. Kofuji P, Hadley RW, Kieval RS, Lederer WJ, Schulze DH: Expression of the Na-Ca exchanger in diverse tissues: a study using the cloned human cardiac Na-Ca exchanger. Am J Physiol. 1992 Dec;263(6 Pt 1):C1241-9.[1476165 ]
  8. Ren X, Philipson KD: The topology of the cardiac Na(+)/Ca(2)(+) exchanger, NCX1. J Mol Cell Cardiol. 2013 Apr;57:68-71. doi: 10.1016/j.yjmcc.2013.01.010. Epub 2013 Jan 31.[23376057 ]
  9. Khananshvili D: The SLC8 gene family of sodium-calcium exchangers (NCX) - structure, function, and regulation in health and disease. Mol Aspects Med. 2013 Apr-Jun;34(2-3):220-35. doi: 10.1016/j.mam.2012.07.003.[23506867 ]
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