Serine hydroxymethyltransferase, cytosolic
| Name | Serine hydroxymethyltransferase, cytosolic |
|---|---|
| Synonyms | 2.1.2.1 Glycine hydroxymethyltransferase Serine methylase SHMT |
| Gene Name | SHMT1 |
| Organism | Human |
| Amino acid sequence | >lcl|BSEQ0000659|Serine hydroxymethyltransferase, cytosolic MTMPVNGAHKDADLWSSHDKMLAQPLKDSDVEVYNIIKKESNRQRVGLELIASENFASRA VLEALGSCLNNKYSEGYPGQRYYGGTEFIDELETLCQKRALQAYKLDPQCWGVNVQPYSG SPANFAVYTALVEPHGRIMGLDLPDGGHLTHGFMTDKKKISATSIFFESMPYKVNPDTGY INYDQLEENARLFHPKLIIAGTSCYSRNLEYARLRKIADENGAYLMADMAHISGLVAAGV VPSPFEHCHVVTTTTHKTLRGCRAGMIFYRKGVKSVDPKTGKEILYNLESLINSAVFPGL QGGPHNHAIAGVAVALKQAMTLEFKVYQHQVVANCRALSEALTELGYKIVTGGSDNHLIL VDLRSKGTDGGRAEKVLEACSIACNKNTCPGDRSALRPSGLRLGTPALTSRGLLEKDFQK VAHFIHRGIELTLQIQSDTGVRATLKEFKERLAGDKYQAAVQALREEVESFASLFPLPGL PDF |
| Number of residues | 483 |
| Molecular Weight | 53082.18 |
| Theoretical pI | 7.77 |
| GO Classification |
Functions
glycine hydroxymethyltransferase activity L-allo-threonine aldolase activity protein homodimerization activity serine binding pyridoxal phosphate binding Processes
branched-chain amino acid catabolic process glycine biosynthetic process from serine vitamin metabolic process tetrahydrofolate interconversion water-soluble vitamin metabolic process protein homotetramerization cellular nitrogen compound metabolic process carnitine biosynthetic process small molecule metabolic process purine nucleobase biosynthetic process L-serine catabolic process dTMP biosynthetic process cellular response to tetrahydrofolate protein tetramerization folic acid metabolic process Components
mitochondrion nucleus cytosol extracellular exosome cytoplasm |
| General Function | Serine binding |
| Specific Function | Interconversion of serine and glycine. |
| Transmembrane Regions | |
| GenBank Protein ID | 307422 |
| UniProtKB ID | P34896 |
| UniProtKB Entry Name | GLYC_HUMAN |
| Cellular Location | Cytoplasm |
| Gene sequence | >lcl|BSEQ0010091|Serine hydroxymethyltransferase, cytosolic (SHMT1) ATGGGCCTGGACCTTCCGGATGGGGGCCACCTGACCCATGGGTTCATGACAGACAAGAAG AAAATCTCTGCCACGTCCATCTTCTTTGAATCTATGCCCTACAAGGTGAACCCAGATACT GGCTACATCAACTATGACCAGCTGGAGGAGAACGCACGCCTCTTCCACCCGAAGCTGATC ATCGCAGGAACCAGCTGCTACTCCCGAAACCTGGAATATGCCCGGCTACGGAAGATTGCA GATGAGAACGGGGCGTATCTCATGGCGGACATGGCTCACATCAGCGGGCTGGTGGCGGCT GGCGTGGTGCCCTCCCCATTTGAACACTGCCATGTGGTGACCACCACCACTCACAAGACC CTGCGAGGCTGCCGAGCTGGCATGATCTTCTACAGGAAAGGAGTGAAAAGTGTGGATCCC AAGACTGGCAAAGAGATTCTGTACAACCTGGAGTCTCTTATCAATTCTGCTGTGTTCCCT GGCCTGCAGGGAGGTCCCCACAACCACGCCATTGCTGGGGTTGCTGTGGCACTGAAGCAA GCTATGACTCTGGAATTTAAAGTTTATCAACACCAGGTGGTGGCCAACTGCAGGGCTCTG TCTGAGGCCCTGACGGAGCTGGGCTACAAAATAGTCACAGGTGGTTCTGACAACCATTTG ATCCTTGTGGATCTCCGTTCCAAAGGCACAGATGGTGGAAGGGCTGAGAAGGTGCTAGAA GCCTGTTCTATTGCCTGCAACAAGAACACCTGTCCAGGTGACAGAAGCGCTCTGCGGCCC AGTGGACTGCGGCTGGGGACCCCAGCACTGACGTCCCGTGGACTTTTGGAAAAAGACTTC CAAAAAGTAGCCCACTTTATTCACAGAGGGATAGAGCTGACCCTGCAGATCCAGAGCGAC ACTGGTGTCAGAGCCACCCTGAAAGAGTTCAAGGAGAGACTGGCAGGGGATAAGTACCAG GCGGCCGTGCAGGCTCTCCGGGAGGAGGTTGAGAGCTTCGCCTCTCTCTTCCCTCTGCCT GGCCTGCCTGACTTCTAA |
| GenBank Gene ID | L11931 |
| GeneCard ID | None |
| GenAtlas ID | SHMT1 |
| HGNC ID | HGNC:10850 |
| Chromosome Location | 17 |
| Locus | 17p11.2 |
| References |
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Related FRC
| FRCD ID | Name | Exact Mass | Structure |
|---|---|---|---|
Glycine |
75.067 |