Gamma-aminobutyric acid receptor subunit alpha-3

NameGamma-aminobutyric acid receptor subunit alpha-3
SynonymsGABA(A) receptor subunit alpha-3
Gene NameGABRA3
OrganismHuman
Amino acid sequence
>lcl|BSEQ0016119|Gamma-aminobutyric acid receptor subunit alpha-3
MIITQTSHCYMTSLGILFLINILPGTTGQGESRRQEPGDFVKQDIGGLSPKHAPDIPDDS
TDNITIFTRILDRLLDGYDNRLRPGLGDAVTEVKTDIYVTSFGPVSDTDMEYTIDVFFRQ
TWHDERLKFDGPMKILPLNNLLASKIWTPDTFFHNGKKSVAHNMTTPNKLLRLVDNGTLL
YTMRLTIHAECPMHLEDFPMDVHACPLKFGSYAYTTAEVVYSWTLGKNKSVEVAQDGSRL
NQYDLLGHVVGTEIIRSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLN
RESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVN
YFTKRSWAWEGKKVPEALEMKKKTPAAPAKKTSTTFNIVGTTYPINLAKDTEFSTISKGA
APSASSTPTIIASPKATYVQDSPTETKTYNSVSKVDKISRIIFPVLFAIFNLVYWATYVN
RESAIKGMIRKQ
Number of residues492
Molecular Weight55164.055
Theoretical pI8.93
GO Classification
Functions
    chloride channel activity
GABA-A receptor activity
benzodiazepine receptor activity
inhibitory extracellular ligand-gated ion channel activity
Processes
    response to drug
chloride transmembrane transport
regulation of membrane potential
gamma-aminobutyric acid signaling pathway
neurological system process
synaptic transmission
transmembrane transport
transport
ion transmembrane transport
Components
    synapse
postsynaptic membrane
neuron projection
plasma membrane
chloride channel complex
GABA-A receptor complex
cell junction
integral component of plasma membrane
General FunctionInhibitory extracellular ligand-gated ion channel activity
Specific FunctionGABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel.
Transmembrane Regions277-298 304-325 338-359 458-479
GenBank Protein ID386424
UniProtKB IDP34903
UniProtKB Entry NameGBRA3_HUMAN
Cellular LocationCell junction
Gene sequence
>lcl|BSEQ0016120|Gamma-aminobutyric acid receptor subunit alpha-3 (GABRA3)
ATGATAATCACACAAACAAGTCACTGTTACATGACCAGCCTTGGGATTCTTTTCCTGATT
AATATTCTCCCTGGAACCACTGGTCAAGGGGAATCAAGACGACAAGAACCCGGGGACTTT
GTGAAGCAGGACATTGGCGGGCTGTCTCCTAAGCATGCCCCAGATATTCCTGATGACAGC
ACTGACAACATCACTATCTTCACCAGAATCTTGGATCGTCTTCTGGACGGCTATGACAAC
CGGCTGCGACCTGGGCTTGGAGATGCAGTGACTGAAGTGAAGACTGACATCTACGTGACC
AGTTTTGGCCCTGTGTCAGACACTGACATGGAGTACACTATTGATGTATTTTTTCGGCAG
ACATGGCATGATGAAAGACTGAAATTTGATGGCCCCATGAAGATCCTTCCACTGAACAAT
CTCCTGGCTAGTAAGATCTGGACACCGGACACCTTCTTCCACAATGGCAAGAAATCAGTG
GCTCATAACATGACCACGCCCAACAAGCTGCTCAGATTGGTGGACAACGGAACCCTCCTC
TATACAATGAGGTTAACAATTCATGCTGAGTGTCCCATGCATTTGGAAGATTTTCCCATG
GATGTGCATGCCTGCCCACTGAAGTTTGGAAGCTATGCCTATACAACAGCTGAAGTGGTT
TATTCTTGGACTCTCGGAAAGAACAAATCCGTGGAAGTGGCACAGGATGGTTCTCGCTTG
AACCAGTATGACCTTTTGGGCCATGTTGTTGGGACAGAGATAATCCGGTCTAGTACAGGA
GAATATGTCGTCATGACAACCCACTTCCATCTCAAGCGAAAAATTGGCTACTTTGTGATC
CAGACCTACTTGCCATGTATCATGACTGTCATTCTGTCACAAGTGTCGTTCTGGCTCAAC
AGAGAGTCTGTTCCTGCCCGTACAGTCTTTGGTGTCACCACTGTGCTTACCATGACCACC
TTGAGTATCAGTGCCAGAAATTCCTTACCTAAAGTGGCATATGCGACGGCCATGGACTGG
TTCATAGCCGTCTGTTATGCCTTTGTATTTTCTGCACTGATTGAATTTGCCACTGTCAAC
TATTTCACCAAGCGGAGTTGGGCTTGGGAAGGCAAGAAGGTGCCAGAGGCCCTGGAGATG
AAGAAGAAAACACCAGCAGCCCCAGCAAAGAAAACCAGCACTACCTTCAACATCGTGGGG
ACCACCTATCCCATCAACCTGGCCAAGGACACTGAATTTTCCACCATCTCCAAGGGCGCT
GCTCCCAGTGCCTCCTCAACCCCAACAATCATTGCTTCACCCAAGGCCACCTACGTGCAG
GACAGCCCGACTGAGACCAAGACCTACAACAGTGTCAGCAAGGTTGACAAAATTTCCCGC
ATCATCTTTCCTGTGCTCTTTGCCATATTCAATCTGGTCTATTGGGCCACATATGTCAAC
CGGGAGTCAGCTATCAAGGGCATGATCCGCAAACAGTAG
GenBank Gene IDS62908
GeneCard IDNone
GenAtlas IDGABRA3
HGNC IDHGNC:4077
Chromosome LocationX
LocusXq28
References
  1. Hadingham KL, Wingrove P, Le Bourdelles B, Palmer KJ, Ragan CI, Whiting PJ: Cloning of cDNA sequences encoding human alpha 2 and alpha 3 gamma-aminobutyric acidA receptor subunits and characterization of the benzodiazepine pharmacology of recombinant alpha 1-, alpha 2-, alpha 3-, and alpha 5-containing human gamma-aminobutyric acidA receptors. Mol Pharmacol. 1993 Jun;43(6):970-5.[8391122 ]
  2. Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. 2004 Oct;14(10B):2121-7.[15489334 ]
  3. Amir R, Dahle EJ, Toriolo D, Zoghbi HY: Candidate gene analysis in Rett syndrome and the identification of 21 SNPs in Xq. Am J Med Genet. 2000 Jan 3;90(1):69-71.[10602120 ]

Related FRC

FRCD ID Name Exact Mass Structure




F04687



Muscimol hydrobromide


195.016




F04791



Cicutoxin


258.361




F04797



Oenanthotoxin


258.361




F04973



Aflatrem


501.667




F04979



Penitrem A


634.21




F04980



Penitrem B


583.769




F04981



Penitrem C


602.212




F04987



Fumitremorgin A


579.694




F04988



Fumitremorgin B


479.577




F04989



Fumitremorgin C


379.46




F04993



Paspalinine


433.548




F05005



Janthitrem B


585.785




F05017



Paspalitrem A


501.667




F05018



Paspalicine


417.549




F05019



Paxilline


435.564




F05021



Verruculogen


511.575




F05219



Bicuculline


367.357




F05454



Eszopiclone


388.812




F05465



Lormetazepam


335.184




F04752



Zolpidem


307.397




F04769



Diazepam


284.74




F04789



Anisatin


328.317




F05006



Janthitrem C


569.786




F05007



Janthitrem E


603.8




F05008



Janthitrem F


645.837




F05009



Janthitrem G


629.838




F05020



Verrucosidin


416.514




F03275



Chloroform


119.369




F03276



Clofenotane


354.476




F03280



Trichloroethylene


131.38




F03281



Dieldrin


380.895




F03283



Chlordane


409.758




F03285



Hexachlorobutadiene


260.744




F03291



Toxaphene


411.774




F03293



Tetrachloroethylene


165.822




F03294



Heptachlor


373.3




F03299



3,3'-Dichlorobenzidine


253.126




F03300



Endrin


380.895




F03303



Pentachlorophenol


266.323




F03324



Toluene


92.141




F03332



1,1-Dichloroethene


96.938




F03336



1,2-Dichloroethane


98.954




F03337



2,4,6-Trichlorophenol


197.439




F03341



Hexachlorobenzene


284.766




F03344



1,1,1-Trichloroethane


133.396




F03349



Chlorobenzene


112.556




F03360



1,2,3-Trichlorobenzene


181.44




F03370



Chlorpyrifos


350.575




F03381



Chlordecone


490.609




F03386



Dicofol


370.475




F03388



1,1,2,2-Tetrachloroethane


167.838




F03395



1,4-Dichlorobenzene


146.998




F03396



1,1-Dichloroethane


98.954




F03400



Hexachlorocyclopentadiene


272.755




F03405



1,2-Dichlorobenzene


146.998




F03424



1,2,4-Trichlorobenzene


181.44




F03756



Methiochlor


377.766




F03757



Chlorbenzylate


325.185




F03879



Ethanol


46.07




F03886



1,3,5-Trichlorobenzene


181.44




F03890



Fipronil


437.141




F03917



Mirex


545.51




F04039



Isodrin


364.896




F04038



Telodrin


411.73