Pulmonary surfactant-associated protein D

NamePulmonary surfactant-associated protein D
SynonymsCOLEC7 Collectin-7 Lung surfactant protein D PSP-D PSPD SFTP4
Gene NameSFTPD
OrganismHuman
Amino acid sequence
>lcl|BSEQ0010774|Pulmonary surfactant-associated protein D
MLLFLLSALVLLTQPLGYLEAEMKTYSHRTMPSACTLVMCSSVESGLPGRDGRDGREGPR
GEKGDPGLPGAAGQAGMPGQAGPVGPKGDNGSVGEPGPKGDTGPSGPPGPPGVPGPAGRE
GPLGKQGNIGPQGKPGPKGEAGPKGEVGAPGMQGSAGARGLAGPKGERGVPGERGVPGNT
GAAGSAGAMGPQGSPGARGPPGLKGDKGIPGDKGAKGESGLPDVASLRQQVEALQGQVQH
LQAAFSQYKKVELFPNGQSVGEKIFKTAGFVKPFTEAQLLCTQAGGQLASPRSAAENAAL
QQLVVAKNEAAFLSMTDSKTEGKFTYPTGESLVYSNWAPGEPNDDGGSEDCVEIFTNGKW
NDRACGEKRLVVCEF
Number of residues375
Molecular Weight37728.19
Theoretical pI6.54
GO Classification
Functions
    carbohydrate binding
Processes
    regulation of immune response
cellular protein metabolic process
defense response to bacterium
negative regulation of interleukin-2 biosynthetic process
positive regulation of phagocytosis
surfactant homeostasis
negative regulation of T cell proliferation
respiratory gaseous exchange
reactive oxygen species metabolic process
lung alveolus development
innate immune response
regulation of cytokine production
receptor-mediated endocytosis
macrophage chemotaxis
Components
    clathrin-coated endocytic vesicle
collagen trimer
extracellular region
extracellular space
endocytic vesicle
endoplasmic reticulum membrane
proteinaceous extracellular matrix
lysosome
General FunctionCarbohydrate binding
Specific FunctionContributes to the lung's defense against inhaled microorganisms, organic antigens and toxins. Interacts with compounds such as bacterial lipopolysaccharides, oligosaccharides and fatty acids and modulates leukocyte action in immune response. May participate in the extracellular reorganization or turnover of pulmonary surfactant. Binds strongly maltose residues and to a lesser extent other alpha-glucosyl moieties.
Transmembrane Regions
GenBank Protein ID34767
UniProtKB IDP35247
UniProtKB Entry NameSFTPD_HUMAN
Cellular LocationSecreted
Gene sequence
>lcl|BSEQ0010775|Pulmonary surfactant-associated protein D (SFTPD)
ATGCTGCTCTTCCTCCTCTCTGCACTGGTCCTGCTCACACAGCCCCTGGGCTACCTGGAA
GCAGAAATGAAGACCTACTCCCACAGAACAATGCCCAGTGCTTGCACCCTGGTCATGTGT
AGCTCAGTGGAGAGTGGCCTGCCTGGTCGCGATGGACGGGATGGGAGAGAGGGCCCTCGG
GGCGAGAAGGGGGACCCAGGTTTGCCAGGAGCTGCAGGGCAAGCAGGGATGCCTGGACAA
GCTGGCCCAGTTGGGCCCAAAGGGGACAATGGCTCTGTTGGAGAACCTGGACCAAAGGGA
GACACTGGGCCAAGTGGACCTCCAGGACCTCCCGGTGTGCCTGGTCCAGCTGGAAGAGAA
GGTCCCCTGGGGAAGCAGGGGAACATAGGACCTCAGGGCAAGCCAGGCCCAAAAGGAGAA
GCTGGGCCCAAAGGAGAAGTAGGTGCCCCAGGCATGCAGGGCTCGGCAGGGGCAAGAGGC
CTCGCAGGCCCTAAGGGAGAGCGAGGTGTCCCTGGTGAGCGTGGAGTCCCTGGAAACACA
GGGGCAGCAGGGTCTGCTGGAGCCATGGGTCCCCAGGGAAGTCCAGGTGCCAGGGGACCC
CCGGGATTGAAGGGGGACAAAGGCATTCCTGGAGACAAAGGAGCAAAGGGAGAAAGTGGG
CTTCCAGATGTTGCTTCTCTGAGGCAGCAGGTTGAGGCCTTACAGGGACAAGTACAGCAC
CTCCAGGCTGCTTTCTCTCAGTATAAGAAAGTTGAGCTCTTCCCAAATGGCCAAAGTGTC
GGGGAGAAGATTTTCAAGACAGCAGGCTTTGTAAAACCATTTACGGAGGCACAGCTGCTG
TGCACACAGGCTGGTGGACAGTTGGCCTCTCCACGCTCTGCCGCTGAGAATGCCGCCTTG
CAACAGCTGGTCGTAGCTAAGAACGAGGCTGCTTTCCTGAGCATGACTGATTCCAAGACA
GAGGGCAAGTTCACCTACCCCACAGGAGAGTCCCTGGTCTATTCCAACTGGGCCCCAGGG
GAGCCCAACGATGATGGCGGGTCAGAGGACTGTGTGGAGATCTTCACCAATGGCAAGTGG
AATGACAGGGCTTGTGGAGAAAAGCGTCTTGTGGTCTGCGAGTTCTGA
GenBank Gene IDX65018
GeneCard IDNone
GenAtlas IDSFTPD
HGNC IDHGNC:10803
Chromosome Location10
Locus10q22.2-q23.1
References
  1. Lu J, Willis AC, Reid KB: Purification, characterization and cDNA cloning of human lung surfactant protein D. Biochem J. 1992 Jun 15;284 ( Pt 3):795-802.[1339284 ]
  2. Crouch E, Rust K, Veile R, Donis-Keller H, Grosso L: Genomic organization of human surfactant protein D (SP-D). SP-D is encoded on chromosome 10q22.2-23.1. J Biol Chem. 1993 Feb 5;268(4):2976-83.[8428971 ]
  3. Crouch E, Persson A, Chang D: Accumulation of surfactant protein D in human pulmonary alveolar proteinosis. Am J Pathol. 1993 Jan;142(1):241-8.[8424457 ]
  4. Rust K, Grosso L, Zhang V, Chang D, Persson A, Longmore W, Cai GZ, Crouch E: Human surfactant protein D: SP-D contains a C-type lectin carbohydrate recognition domain. Arch Biochem Biophys. 1991 Oct;290(1):116-26.[1898081 ]
  5. Ortega FJ, Pueyo N, Moreno-Navarrete JM, Sabater M, Rodriguez-Hermosa JI, Ricart W, Tinahones FJ, Fernandez-Real JM: The lung innate immune gene surfactant protein-D is expressed in adipose tissue and linked to obesity status. Int J Obes (Lond). 2013 Dec;37(12):1532-8. doi: 10.1038/ijo.2013.23. Epub 2013 Mar 12.[23478426 ]
  6. Hakansson K, Lim NK, Hoppe HJ, Reid KB: Crystal structure of the trimeric alpha-helical coiled-coil and the three lectin domains of human lung surfactant protein D. Structure. 1999 Mar 15;7(3):255-64.[10368295 ]
  7. Wang Y, Kuan PJ, Xing C, Cronkhite JT, Torres F, Rosenblatt RL, DiMaio JM, Kinch LN, Grishin NV, Garcia CK: Genetic defects in surfactant protein A2 are associated with pulmonary fibrosis and lung cancer. Am J Hum Genet. 2009 Jan;84(1):52-9. doi: 10.1016/j.ajhg.2008.11.010. Epub 2008 Dec 18.[19100526 ]
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