Alpha-1A adrenergic receptor
Name | Alpha-1A adrenergic receptor |
---|---|
Synonyms | ADRA1C Alpha-1A adrenoceptor Alpha-1A adrenoreceptor Alpha-1C adrenergic receptor Alpha-adrenergic receptor 1c |
Gene Name | ADRA1A |
Organism | Human |
Amino acid sequence | >lcl|BSEQ0001000|Alpha-1A adrenergic receptor MVFLSGNASDSSNCTQPPAPVNISKAILLGVILGGLILFGVLGNILVILSVACHRHLHSV THYYIVNLAVADLLLTSTVLPFSAIFEVLGYWAFGRVFCNIWAAVDVLCCTASIMGLCII SIDRYIGVSYPLRYPTIVTQRRGLMALLCVWALSLVISIGPLFGWRQPAPEDETICQINE EPGYVLFSALGSFYLPLAIILVMYCRVYVVAKRESRGLKSGLKTDKSDSEQVTLRIHRKN APAGGSGMASAKTKTHFSVRLLKFSREKKAAKTLGIVVGCFVLCWLPFFLVMPIGSFFPD FKPSETVFKIVFWLGYLNSCINPIIYPCSSQEFKKAFQNVLRIQCLCRKQSSKHALGYTL HPPSQAVEGQHKDMVRIPVGSRETFYRISKTDGVCEWKFFSSMPRGSARITVSKDQSSCT TARVRSKSFLQVCCCVGPSTPSLDKNHQVPTIKVHTISLSENGEEV |
Number of residues | 466 |
Molecular Weight | 51486.005 |
Theoretical pI | 9.23 |
GO Classification |
Functions
alpha1-adrenergic receptor activity protein heterodimerization activity Processes
positive regulation of synaptic transmission, GABAergic norepinephrine-epinephrine vasoconstriction involved in regulation of systemic arterial blood pressure calcium ion transport into cytosol positive regulation of cytosolic calcium ion concentration activation of phospholipase C activity negative regulation of Rho protein signal transduction positive regulation of vasoconstriction positive regulation of cardiac muscle contraction apoptotic process positive regulation of action potential signal transduction negative regulation of cell proliferation positive regulation of ERK1 and ERK2 cascade G-protein coupled receptor signaling pathway aging response to drug positive regulation of smooth muscle contraction response to hormone smooth muscle contraction positive regulation of MAPK cascade intracellular signal transduction positive regulation of protein kinase C signaling cell-cell signaling adenylate cyclase-activating adrenergic receptor signaling pathway phospholipase C-activating G-protein coupled receptor signaling pathway Components
nuclear membrane integral component of plasma membrane nucleus plasma membrane cytosol |
General Function | Protein heterodimerization activity |
Specific Function | This alpha-adrenergic receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. Its effect is mediated by G(q) and G(11) proteins. Nuclear ADRA1A-ADRA1B heterooligomers regulate phenylephrine(PE)-stimulated ERK signaling in cardiac myocytes. |
Transmembrane Regions | 28-51 65-88 100-122 144-167 182-205 274-297 306-329 |
GenBank Protein ID | 433201 |
UniProtKB ID | P35348 |
UniProtKB Entry Name | ADA1A_HUMAN |
Cellular Location | Nucleus membrane |
Gene sequence | >lcl|BSEQ0010352|Alpha-1A adrenergic receptor (ADRA1A) ATGGTGTTTCTCTCGGGAAATGCTTCCGACAGCTCCAACTGCACCCAACCGCCGGCACCG GTGAACATTTCCAAGGCCATTCTGCTCGGGGTGATCTTGGGGGGCCTCATTCTTTTCGGG GTGCTGGGTAACATCCTAGTGATCCTCTCCGTAGCCTGTCACCGACACCTGCACTCAGTC ACGCACTACTACATCGTCAACCTGGCGGTGGCCGACCTCCTGCTCACCTCCACGGTGCTG CCCTTCTCCGCCATCTTCGAGGTCCTAGGCTACTGGGCCTTCGGCAGGGTCTTCTGCAAC ATCTGGGCGGCAGTGGATGTGCTGTGCTGCACCGCGTCCATCATGGGCCTCTGCATCATC TCCATCGACCGCTACATCGGCGTGAGCTACCCGCTGCGCTACCCAACCATCGTCACCCAG AGGAGGGGTCTCATGGCTCTGCTCTGCGTCTGGGCACTCTCCCTGGTCATATCCATTGGA CCCCTGTTCGGCTGGAGGCAGCCGGCCCCCGAGGACGAGACCATCTGCCAGATCAACGAG GAGCCGGGCTACGTGCTCTTCTCAGCGCTGGGCTCCTTCTACCTGCCTCTGGCCATCATC CTGGTCATGTACTGCCGCGTCTACGTGGTGGCCAAGAGGGAGAGCCGGGGCCTCAAGTCT GGCCTCAAGACCGACAAGTCGGACTCGGAGCAAGTGACGCTCCGCATCCATCGGAAAAAC GCCCCGGCAGGAGGCAGCGGGATGGCCAGCGCCAAGACCAAGACGCACTTCTCAGTGAGG CTCCTCAAGTTCTCCCGGGAGAAGAAAGCGGCCAAAACGCTGGGCATCGTGGTCGGCTGC TTCGTCCTCTGCTGGCTGCCTTTTTTCTTAGTCATGCCCATTGGGTCTTTCTTCCCTGAT TTCAAGCCCTCTGAAACAGTTTTTAAAATAGTATTTTGGCTCGGATATCTAAACAGCTGC ATCAACCCCATCATATACCCATGCTCCAGCCAAGAGTTCAAAAAGGCCTTTCAGAATGTC TTGAGAATCCAGTGTCTCTGCAGAAAGCAGTCTTCCAAACATGCCCTGGGCTACACCCTG CACCCGCCCAGCCAGGCCGTGGAAGGGCAACACAAGGACATGGTGCGCATCCCCGTGGGA TCAAGAGAGACCTTCTACAGGATCTCCAAGACGGATGGCGTTTGTGAATGGAAATTTTTC TCTTCCATGCCCCGTGGATCTGCCAGGATTACAGTGTCCAAAGACCAATCCTCCTGTACC ACAGCCCGGGTGAGAAGTAAAAGCTTTTTGCAGGTCTGCTGCTGTGTAGGGCCCTCAACC CCCAGCCTTGACAAGAACCATCAAGTTCCAACCATTAAGGTCCACACCATCTCCCTCAGT GAGAACGGGGAGGAAGTCTAG |
GenBank Gene ID | D25235 |
GeneCard ID | None |
GenAtlas ID | ADRA1A |
HGNC ID | HGNC:277 |
Chromosome Location | 8 |
Locus | 8p21-p11.2 |
References |
|