Prostaglandin G/H synthase 2

NameProstaglandin G/H synthase 2
Synonyms1.14.99.1 COX-2 COX2 Cyclooxygenase-2 PGH synthase 2 PGHS-2 PHS II Prostaglandin H2 synthase 2 Prostaglandin-endoperoxide synthase 2
Gene NamePTGS2
OrganismHuman
Amino acid sequence
>lcl|BSEQ0021832|Prostaglandin G/H synthase 2
MLARALLLCAVLALSHTANPCCSHPCQNRGVCMSVGFDQYKCDCTRTGFYGENCSTPEFL
TRIKLFLKPTPNTVHYILTHFKGFWNVVNNIPFLRNAIMSYVLTSRSHLIDSPPTYNADY
GYKSWEAFSNLSYYTRALPPVPDDCPTPLGVKGKKQLPDSNEIVEKLLLRRKFIPDPQGS
NMMFAFFAQHFTHQFFKTDHKRGPAFTNGLGHGVDLNHIYGETLARQRKLRLFKDGKMKY
QIIDGEMYPPTVKDTQAEMIYPPQVPEHLRFAVGQEVFGLVPGLMMYATIWLREHNRVCD
VLKQEHPEWGDEQLFQTSRLILIGETIKIVIEDYVQHLSGYHFKLKFDPELLFNKQFQYQ
NRIAAEFNTLYHWHPLLPDTFQIHDQKYNYQQFIYNNSILLEHGITQFVESFTRQIAGRV
AGGRNVPPAVQKVSQASIDQSRQMKYQSFNEYRKRFMLKPYESFEELTGEKEMSAELEAL
YGDIDAVELYPALLVEKPRPDAIFGETMVEVGAPFSLKGLMGNVICSPAYWKPSTFGGEV
GFQIINTASIQSLICNNVKGCPFTSFSVPDPELIKTVTINASSSRSGLDDINPTVLLKER
STEL
Number of residues604
Molecular Weight68995.625
Theoretical pI7.41
GO Classification
Functions
    prostaglandin-endoperoxide synthase activity
lipid binding
heme binding
metal ion binding
arachidonate 15-lipoxygenase activity
enzyme binding
peroxidase activity
Processes
    cellular response to UV
positive regulation of apoptotic process
response to lithium ion
response to glucocorticoid
positive regulation of nitric oxide biosynthetic process
cellular response to hypoxia
negative regulation of smooth muscle contraction
response to fatty acid
response to lipopolysaccharide
positive regulation of synaptic transmission, glutamatergic
memory
cellular response to mechanical stimulus
positive regulation of fever generation
sensory perception of pain
cellular response to fluid shear stress
response to drug
positive regulation of vascular endothelial growth factor production
positive regulation of brown fat cell differentiation
response to estradiol
brown fat cell differentiation
positive regulation of NF-kappaB import into nucleus
arachidonic acid metabolic process
maintenance of blood-brain barrier
negative regulation of cell proliferation
negative regulation of calcium ion transport
cellular response to ATP
response to tumor necrosis factor
response to oxidative stress
lipoxygenase pathway
positive regulation of synaptic plasticity
positive regulation of smooth muscle contraction
response to vitamin D
angiogenesis
positive regulation of transforming growth factor beta production
regulation of blood pressure
decidualization
negative regulation of synaptic transmission, dopaminergic
regulation of inflammatory response
movement of cell or subcellular component
nicotinamide metabolic process
inflammatory response
response to manganese ion
cyclooxygenase pathway
hair cycle
NAD metabolic process
learning
prostaglandin biosynthetic process
negative regulation of cell cycle
positive regulation of fibroblast growth factor production
vitamin metabolic process
positive regulation of prostaglandin biosynthetic process
positive regulation of cell migration involved in sprouting angiogenesis
bone mineralization
positive regulation of platelet-derived growth factor production
water-soluble vitamin metabolic process
ovulation
positive regulation of vasoconstriction
response to fructose
small molecule metabolic process
embryo implantation
prostaglandin metabolic process
positive regulation of smooth muscle cell proliferation
Components
    nucleus
endoplasmic reticulum lumen
endoplasmic reticulum
caveola
endoplasmic reticulum membrane
cytoplasm
protein complex
neuron projection
General FunctionProstaglandin-endoperoxide synthase activity
Specific FunctionConverts arachidonate to prostaglandin H2 (PGH2), a committed step in prostanoid synthesis. Constitutively expressed in some tissues in physiological conditions, such as the endothelium, kidney and brain, and in pathological conditions, such as in cancer. PTGS2 is responsible for production of inflammatory prostaglandins. Up-regulation of PTGS2 is also associated with increased cell adhesion, phenotypic changes, resistance to apoptosis and tumor angiogenesis. In cancer cells, PTGS2 is a key step in the production of prostaglandin E2 (PGE2), which plays important roles in modulating motility, proliferation and resistance to apoptosis.
Transmembrane Regions
GenBank Protein ID291988
UniProtKB IDP35354
UniProtKB Entry NamePGH2_HUMAN
Cellular LocationMicrosome membrane
Gene sequence
>lcl|BSEQ0021833|Prostaglandin G/H synthase 2 (PTGS2)
ATGCTCGCCCGCGCCCTGCTGCTGTGCGCGGTCCTGGCGCTCAGCCATACAGCAAATCCT
TGCTGTTCCCACCCATGTCAAAACCGAGGTGTATGTATGAGTGTGGGATTTGACCAGTAT
AAGTGCGATTGTACCCGGACAGGATTCTATGGAGAAAACTGCTCAACACCGGAATTTTTG
ACAAGAATAAAATTATTTCTGAAACCCACTCCAAACACAGTGCACTACATACTTACCCAC
TTCAAGGGATTTTGGAACGTTGTGAATAACATTCCCTTCCTTCGAAATGCAATTATGAGT
TATGTGTTGACATCCAGATCACATTTGATTGACAGTCCACCAACTTACAATGCTGACTAT
GGCTACAAAAGCTGGGAAGCCTTCTCTAACCTCTCCTATTATACTAGAGCCCTTCCTCCT
GTGCCTGATGATTGCCCGACTCCCTTGGGTGTCAAAGGTAAAAAGCAGCTTCCTGATTCA
AATGAGATTGTGGAAAAATTGCTTCTAAGAAGAAAGTTCATCCCTGATCCCCAGGGCTCA
AACATGATGTTTGCATTCTTTGCCCAGCACTTCACGCATCAGTTTTTCAAGACAGATCAT
AAGCGAGGGCCAGCTTTCACCAACGGGCTGGGCCATGGGGTGGACTTAAATCATATTTAC
GGTGAAACTCTGGCTAGACAGCGTAAACTGCGCCTTTTCAAGGATGGAAAAATGAAATAT
CAGATAATTGATGGAGAGATGTATCCTCCCACAGTCAAAGATACTCAGGCAGAGATGATC
TACCCTCCTCAAGTCCCTGAGCATCTACGGTTTGCTGTGGGGCAGGAGGTCTTTGGTCTG
GTGCCTGGTCTGATGATGTATGCCACAATCTGGCTGCGGGAACACAACAGAGTATGCGAT
GTGCTTAAACAGGAGCATCCTGAATGGGGTGATGAGCAGTTGTTCCAGACAAGCAGGCTA
ATACTGATAGGAGAGACTATTAAGATTGTGATTGAAGATTATGTGCAACACTTGAGTGGC
TATCACTTCAAACTGAAATTTGACCCAGAACTACTTTTCAACAAACAATTCCAGTACCAA
AATCGTATTGCTGCTGAATTTAACACCCTCTATCACTGGCATCCCCTTCTGCCTGACACC
TTTCAAATTCATGACCAGAAATACAACTATCAACAGTTTATCTACAACAACTCTATATTG
CTGGAACATGGAATTACCCAGTTTGTTGAATCATTCACCAGGCAAATTGCTGGCAGGGTT
GCTGGTGGTAGGAATGTTCCACCCGCAGTACAGAAAGTATCACAGGCTTCCATTGACCAG
AGCAGGCAGATGAAATACCAGTCTTTTAATGAGTACCGCAAACGCTTTATGCTGAAGCCC
TATGAATCATTTGAAGAACTTACAGGAGAAAAGGAAATGTCTGCAGAGTTGGAAGCACTC
TATGGTGACATCGATGCTGTGGAGCTGTATCCTGCCCTTCTGGTAGAAAAGCCTCGGCCA
GATGCCATCTTTGGTGAAACCATGGTAGAAGTTGGAGCACCATTCTCCTTGAAAGGACTT
ATGGGTAATGTTATATGTTCTCCTGCCTACTGGAAGCCAAGCACTTTTGGTGGAGAAGTG
GGTTTTCAAATCATCAACACTGCCTCAATTCAGTCTCTCATCTGCAATAACGTGAAGGGC
TGTCCCTTTACTTCATTCAGTGTTCCAGATCCAGAGCTCATTAAAACAGTCACCATCAAT
GCAAGTTCTTCCCGCTCCGGACTAGATGATATCAATCCCACAGTACTACTAAAAGAACGT
TCGACTGAACTGTAG
GenBank Gene IDL15326
GeneCard IDNone
GenAtlas IDPTGS2
HGNC IDHGNC:9605
Chromosome Location1
Locus1q25.2-q25.3
References
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