Glutaredoxin-1


NameGlutaredoxin-1
SynonymsGRX Thioltransferase-1 TTase-1
Gene NameGLRX
OrganismHuman
Amino acid sequence
>lcl|BSEQ0011645|Glutaredoxin-1
MAQEFVNCKIQPGKVVVFIKPTCPYCRRAQEILSQLPIKQGLLEFVDITATNHTNEIQDY
LQQLTGARTVPRVFIGKDCIGGCSDLVSLQQSGELLTRLKQIGALQ
Number of residues106
Molecular Weight11775.665
Theoretical pI8.21
GO Classification
Functions
    electron carrier activity
    protein N-terminus binding
    glutathione disulfide oxidoreductase activity
    glutathione oxidoreductase activity
Processes
    positive regulation of membrane potential
    cell redox homeostasis
    positive regulation of sodium ion transmembrane transporter activity
    protein deglutathionylation
    small molecule metabolic process
    nucleobase-containing small molecule metabolic process
    nucleobase-containing small molecule interconversion
Components
    cytosol
    extracellular exosome
    mitochondrion
    nucleus
General FunctionProtein n-terminus binding
Specific FunctionHas a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins.
Transmembrane Regions
GenBank Protein ID643695
UniProtKB IDP35754
UniProtKB Entry NameGLRX1_HUMAN
Cellular LocationCytoplasm
Gene sequence
>lcl|BSEQ0011646|Glutaredoxin-1 (GLRX)
ATGGCTCAAGAGTTTGTGAACTGCAAAATCCAGCCTGGGAAGGTGGTTGTGTTCATCAAG
CCCACCTGCCCGTACTGCAGGAGGGCCCAAGAGATCCTCAGTCAATTGCCCATCAAACAA
GGGCTTCTGGAATTTGTCGATATCACAGCCACCAACCACACTAACGAGATTCAAGATTAT
TTGCAACAGCTCACGGGAGCAAGAACGGTGCCTCGAGTCTTTATTGGTAAAGATTGTATA
GGCGGATGCAGTGATCTAGTCTCTTTGCAACAGAGTGGGGAACTGCTGACGCGGCTAAAG
CAGATTGGAGCTCTGCAGTAA
GenBank Gene IDD21238
GeneCard IDNone
GenAtlas IDGLRX
HGNC IDHGNC:4330
Chromosome Location5
Locus5q14
References
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  3. Burkard TR, Planyavsky M, Kaupe I, Breitwieser FP, Burckstummer T, Bennett KL, Superti-Furga G, Colinge J: Initial characterization of the human central proteome. BMC Syst Biol. 2011 Jan 26;5:17. doi: 10.1186/1752-0509-5-17.[21269460 ]
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