Protein phosphatase 1A
| Name | Protein phosphatase 1A |
|---|---|
| Synonyms | 3.1.3.16 PP2C-alpha PPPM1A Protein phosphatase 2C isoform alpha Protein phosphatase IA |
| Gene Name | PPM1A |
| Organism | Human |
| Amino acid sequence | >lcl|BSEQ0009180|Protein phosphatase 1A MGAFLDKPKMEKHNAQGQGNGLRYGLSSMQGWRVEMEDAHTAVIGLPSGLESWSFFAVYD GHAGSQVAKYCCEHLLDHITNNQDFKGSAGAPSVENVKNGIRTGFLEIDEHMRVMSEKKH GADRSGSTAVGVLISPQHTYFINCGDSRGLLCRNRKVHFFTQDHKPSNPLEKERIQNAGG SVMIQRVNGSLAVSRALGDFDYKCVHGKGPTEQLVSPEPEVHDIERSEEDDQFIILACDG IWDVMGNEELCDFVRSRLEVTDDLEKVCNEVVDTCLYKGSRDNMSVILICFPNAPKVSPE AVKKEAELDKYLECRVEEIIKKQGEGVPDLVHVMRTLASENIPSLPPGGELASKRNVIEA VYNRLNPYKNDDTDSTSTDDMW |
| Number of residues | 382 |
| Molecular Weight | 42447.455 |
| Theoretical pI | None |
| GO Classification |
Functions
protein serine/threonine phosphatase activity manganese ion binding magnesium ion binding calmodulin-dependent protein phosphatase activity signal transducer activity R-SMAD binding Processes
transcription, DNA-templated negative regulation of transforming growth factor beta receptor signaling pathway transforming growth factor beta receptor signaling pathway negative regulation of NF-kappaB import into nucleus N-terminal protein myristoylation protein dephosphorylation negative regulation of BMP signaling pathway gene expression dephosphorylation peptidyl-threonine dephosphorylation transcription initiation from RNA polymerase II promoter Wnt signaling pathway positive regulation of I-kappaB kinase/NF-kappaB signaling negative regulation of SMAD protein complex assembly positive regulation of Wnt signaling pathway positive regulation of transcription, DNA-templated negative regulation of I-kappaB kinase/NF-kappaB signaling insulin receptor signaling pathway positive regulation of protein export from nucleus cell cycle arrest negative regulation of transcription from RNA polymerase II promoter Components
cytosol membrane nucleoplasm voltage-gated calcium channel complex nucleus neuron projection |
| General Function | Signal transducer activity |
| Specific Function | Enzyme with a broad specificity. Negatively regulates TGF-beta signaling through dephosphorylating SMAD2 and SMAD3, resulting in their dissociation from SMAD4, nuclear export of the SMADs and termination of the TGF-beta-mediated signaling. Dephosphorylates PRKAA1 and PRKAA2. Plays an important role in the termination of TNF-alpha-mediated NF-kappa-B activation through dephosphorylating and inactivating IKBKB/IKKB. |
| Transmembrane Regions | |
| GenBank Protein ID | |
| UniProtKB ID | P35813 |
| UniProtKB Entry Name | PPM1A_HUMAN |
| Cellular Location | Nucleus |
| Gene sequence | >lcl|BSEQ0017713|Protein phosphatase 1A (PPM1A) ATGGGAGCATTTTTAGACAAGCCAAAGATGGAAAAGCATAATGCCCAGGGGCAGGGTAAT GGGTTGCGATATGGGCTAAGCAGCATGCAAGGCTGGCGTGTTGAAATGGAGGATGCACAT ACGGCTGTGATCGGTTTGCCAAGTGGACTTGAATCGTGGTCATTCTTTGCTGTGTATGAT GGGCATGCTGGTTCTCAGGTTGCCAAATACTGCTGTGAGCATTTGTTAGATCACATCACC AATAACCAGGATTTTAAAGGGTCTGCAGGAGCACCTTCTGTGGAAAATGTAAAGAATGGA ATCAGAACAGGTTTTCTGGAGATTGATGAACACATGAGAGTTATGTCAGAGAAGAAACAT GGTGCAGATAGAAGTGGGTCAACAGCTGTAGGTGTCTTAATTTCTCCCCAACATACTTAT TTCATTAACTGTGGAGACTCAAGAGGTTTACTTTGTAGGAACAGGAAAGTTCATTTCTTC ACACAAGATCACAAACCAAGTAATCCGCTGGAGAAAGAACGAATTCAGAATGCAGGTGGC TCTGTAATGATTCAGCGTGTGAATGGCTCTCTGGCTGTATCGAGGGCCCTTGGGGATTTT GATTACAAATGTGTCCATGGAAAAGGTCCTACTGAGCAGCTTGTCTCACCAGAGCCTGAA GTCCATGATATTGAAAGATCTGAAGAAGATGATCAGTTCATTATCCTTGCATGTGATGGT ATCTGGGATGTTATGGGAAATGAAGAGCTCTGTGATTTTGTAAGATCCAGACTTGAAGTC ACTGATGACCTTGAGAAAGTTTGCAATGAAGTAGTCGACACCTGTTTGTATAAGGGAAGT CGAGACAACATGAGTGTGATTTTGATCTGTTTTCCAAATGCACCCAAAGTATCGCCAGAA GCAGTGAAGAAGGAGGCAGAGTTGGACAAGTACCTGGAATGCAGAGTAGAAGAAATCATA AAGAAGCAGGGGGAAGGCGTCCCCGACTTAGTCCATGTGATGCGCACATTAGCGAGTGAG AACATCCCCAGCCTCCCACCAGGGGGTGAATTGGCAAGCAAGAGGAATGTTATTGAAGCC GTTTACAATAGACTGAATCCTTACAAAAATGACGACACTGACTCTACATCAACAGATGAT ATGTGGTAA |
| GenBank Gene ID | |
| GeneCard ID | None |
| GenAtlas ID | |
| HGNC ID | HGNC:9275 |
| Chromosome Location | 14 |
| Locus | None |
| References |
|
Related FRC
| FRCD ID | Name | Exact Mass | Structure |
|---|---|---|---|
Fumonisin B1 |
721.838 |