Protein phosphatase 1A


NameProtein phosphatase 1A
Synonyms3.1.3.16 PP2C-alpha PPPM1A Protein phosphatase 2C isoform alpha Protein phosphatase IA
Gene NamePPM1A
OrganismHuman
Amino acid sequence
>lcl|BSEQ0009180|Protein phosphatase 1A
MGAFLDKPKMEKHNAQGQGNGLRYGLSSMQGWRVEMEDAHTAVIGLPSGLESWSFFAVYD
GHAGSQVAKYCCEHLLDHITNNQDFKGSAGAPSVENVKNGIRTGFLEIDEHMRVMSEKKH
GADRSGSTAVGVLISPQHTYFINCGDSRGLLCRNRKVHFFTQDHKPSNPLEKERIQNAGG
SVMIQRVNGSLAVSRALGDFDYKCVHGKGPTEQLVSPEPEVHDIERSEEDDQFIILACDG
IWDVMGNEELCDFVRSRLEVTDDLEKVCNEVVDTCLYKGSRDNMSVILICFPNAPKVSPE
AVKKEAELDKYLECRVEEIIKKQGEGVPDLVHVMRTLASENIPSLPPGGELASKRNVIEA
VYNRLNPYKNDDTDSTSTDDMW
Number of residues382
Molecular Weight42447.455
Theoretical pINone
GO Classification
Functions
    protein serine/threonine phosphatase activity
    manganese ion binding
    magnesium ion binding
    calmodulin-dependent protein phosphatase activity
    signal transducer activity
    R-SMAD binding
Processes
    transcription, DNA-templated
    negative regulation of transforming growth factor beta receptor signaling pathway
    transforming growth factor beta receptor signaling pathway
    negative regulation of NF-kappaB import into nucleus
    N-terminal protein myristoylation
    protein dephosphorylation
    negative regulation of BMP signaling pathway
    gene expression
    dephosphorylation
    peptidyl-threonine dephosphorylation
    transcription initiation from RNA polymerase II promoter
    Wnt signaling pathway
    positive regulation of I-kappaB kinase/NF-kappaB signaling
    negative regulation of SMAD protein complex assembly
    positive regulation of Wnt signaling pathway
    positive regulation of transcription, DNA-templated
    negative regulation of I-kappaB kinase/NF-kappaB signaling
    insulin receptor signaling pathway
    positive regulation of protein export from nucleus
    cell cycle arrest
    negative regulation of transcription from RNA polymerase II promoter
Components
    cytosol
    membrane
    nucleoplasm
    voltage-gated calcium channel complex
    nucleus
    neuron projection
General FunctionSignal transducer activity
Specific FunctionEnzyme with a broad specificity. Negatively regulates TGF-beta signaling through dephosphorylating SMAD2 and SMAD3, resulting in their dissociation from SMAD4, nuclear export of the SMADs and termination of the TGF-beta-mediated signaling. Dephosphorylates PRKAA1 and PRKAA2. Plays an important role in the termination of TNF-alpha-mediated NF-kappa-B activation through dephosphorylating and inactivating IKBKB/IKKB.
Transmembrane Regions
GenBank Protein ID
UniProtKB IDP35813
UniProtKB Entry NamePPM1A_HUMAN
Cellular LocationNucleus
Gene sequence
>lcl|BSEQ0017713|Protein phosphatase 1A (PPM1A)
ATGGGAGCATTTTTAGACAAGCCAAAGATGGAAAAGCATAATGCCCAGGGGCAGGGTAAT
GGGTTGCGATATGGGCTAAGCAGCATGCAAGGCTGGCGTGTTGAAATGGAGGATGCACAT
ACGGCTGTGATCGGTTTGCCAAGTGGACTTGAATCGTGGTCATTCTTTGCTGTGTATGAT
GGGCATGCTGGTTCTCAGGTTGCCAAATACTGCTGTGAGCATTTGTTAGATCACATCACC
AATAACCAGGATTTTAAAGGGTCTGCAGGAGCACCTTCTGTGGAAAATGTAAAGAATGGA
ATCAGAACAGGTTTTCTGGAGATTGATGAACACATGAGAGTTATGTCAGAGAAGAAACAT
GGTGCAGATAGAAGTGGGTCAACAGCTGTAGGTGTCTTAATTTCTCCCCAACATACTTAT
TTCATTAACTGTGGAGACTCAAGAGGTTTACTTTGTAGGAACAGGAAAGTTCATTTCTTC
ACACAAGATCACAAACCAAGTAATCCGCTGGAGAAAGAACGAATTCAGAATGCAGGTGGC
TCTGTAATGATTCAGCGTGTGAATGGCTCTCTGGCTGTATCGAGGGCCCTTGGGGATTTT
GATTACAAATGTGTCCATGGAAAAGGTCCTACTGAGCAGCTTGTCTCACCAGAGCCTGAA
GTCCATGATATTGAAAGATCTGAAGAAGATGATCAGTTCATTATCCTTGCATGTGATGGT
ATCTGGGATGTTATGGGAAATGAAGAGCTCTGTGATTTTGTAAGATCCAGACTTGAAGTC
ACTGATGACCTTGAGAAAGTTTGCAATGAAGTAGTCGACACCTGTTTGTATAAGGGAAGT
CGAGACAACATGAGTGTGATTTTGATCTGTTTTCCAAATGCACCCAAAGTATCGCCAGAA
GCAGTGAAGAAGGAGGCAGAGTTGGACAAGTACCTGGAATGCAGAGTAGAAGAAATCATA
AAGAAGCAGGGGGAAGGCGTCCCCGACTTAGTCCATGTGATGCGCACATTAGCGAGTGAG
AACATCCCCAGCCTCCCACCAGGGGGTGAATTGGCAAGCAAGAGGAATGTTATTGAAGCC
GTTTACAATAGACTGAATCCTTACAAAAATGACGACACTGACTCTACATCAACAGATGAT
ATGTGGTAA
GenBank Gene ID
GeneCard IDNone
GenAtlas ID
HGNC IDHGNC:9275
Chromosome Location14
LocusNone
References
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