ATP synthase subunit gamma, mitochondrial

NameATP synthase subunit gamma, mitochondrial
SynonymsATP5C ATP5CL1 F-ATPase gamma subunit
Gene NameATP5C1
OrganismHuman
Amino acid sequence
>lcl|BSEQ0007365|ATP synthase subunit gamma, mitochondrial
MFSRAGVAGLSAWTLQPQWIQVRNMATLKDITRRLKSIKNIQKITKSMKMVAAAKYARAE
RELKPARIYGLGSLALYEKADIKGPEDKKKHLLIGVSSDRGLCGAIHSSIAKQMKSEVAT
LTAAGKEVMLVGIGDKIRGILYRTHSDQFLVAFKEVGRKPPTFGDASVIALELLNSGYEF
DEGSIIFNKFRSVISYKTEEKPIFSLNTVASADSMSIYDDIDADVLQNYQEYNLANIIYY
SLKESTTSEQSARMTAMDNASKNASEMIDKLTLTFNRTRQAVITKELIEIISGAAALD
Number of residues298
Molecular Weight32995.665
Theoretical pI9.71
GO Classification
Functions
    poly(A) RNA binding
proton-transporting ATPase activity, rotational mechanism
transmembrane transporter activity
proton-transporting ATP synthase activity, rotational mechanism
Processes
    respiratory electron transport chain
ATP biosynthetic process
oxidative phosphorylation
small molecule metabolic process
mitochondrial ATP synthesis coupled proton transport
cellular metabolic process
Components
    mitochondrion
membrane
mitochondrial inner membrane
mitochondrial matrix
mitochondrial proton-transporting ATP synthase complex
extracellular exosome
myelin sheath
mitochondrial proton-transporting ATP synthase complex, catalytic core F(1)
General FunctionTransmembrane transporter activity
Specific FunctionMitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(1) domain and the central stalk which is part of the complex rotary element. The gamma subunit protrudes into the catalytic domain formed of alpha(3)beta(3). Rotation of the central stalk against the surrounding alpha(3)beta(3) subunits leads to hydrolysis of ATP in three separate catalytic sites on the beta subunits.
Transmembrane Regions
GenBank Protein ID665586
UniProtKB IDP36542
UniProtKB Entry NameATPG_HUMAN
Cellular LocationMitochondrion
Gene sequence
>lcl|BSEQ0012682|ATP synthase subunit gamma, mitochondrial (ATP5C1)
ATGTTCTCTCGCGCGGGTGTCGCTGGGCTGTCGGCCTGGACCTTGCAGCCGCAATGGATT
CAAGTTCGAAATATGGCAACTTTGAAAGATATCACCAGGAGACTAAAGTCCATCAAAAAC
ATCCAGAAAATTACCAAGTCTATGAAAATGGTAGCGGCAGCAAAATATGCCCGAGCTGAG
AGAGAGCTGAAACCAGCTCGAATATATGGATTGGGATCTTTAGCTCTGTATGAAAAAGCT
GATATCAAGGGGCCTGAAGACAAGAAGAAACACCTCCTTATTGGTGTGTCCTCAGATCGA
GGACTGTGTGGTGCTATTCATTCCTCCATTGCTAAACAGATGAAAAGCGAGGTTGCTACA
CTAACAGCAGCTGGGAAAGAAGTTATGCTTGTTGGAATTGGTGACAAAATCAGAGGCATA
CTTTATAGGACTCATTCTGACCAGTTTCTGGTGGCATTCAAAGAAGTGGGAAGAAAGCCC
CCCACTTTTGGAGATGCGTCAGTCATTGCCCTTGAATTACTAAATTCTGGATATGAATTT
GATGAAGGCTCCATCATCTTTAATAAATTCAGGTCTGTCATCTCCTATAAGACAGAAGAA
AAGCCCATCTTTTCCCTTAATACCGTTGCAAGTGCTGACAGCATGAGTATCTATGACGAT
ATTGATGCTGACGTGCTGCAAAATTACCAAGAATACAATCTGGCCAACATCATCTACTAC
TCTCTGAAGGAGTCCACCACTAGTGAGCAGAGTGCCAGGATGACAGCCATGGACAATGCC
AGCAAGAATGCTTCTGAGATGATTGACAAATTGACATTGACATTCAACCGTACCCGCCAA
GCTGTCATCACAAAAGAGTTGATTGAAATTATCTCTGGTGCTGCAGCTCTGGATTAA
GenBank Gene IDD16562
GeneCard IDNone
GenAtlas ID
HGNC IDHGNC:833
Chromosome Location10
Locus10p15.1
References
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