Neuronal acetylcholine receptor subunit alpha-7
Name | Neuronal acetylcholine receptor subunit alpha-7 |
---|---|
Synonyms | NACHRA7 |
Gene Name | CHRNA7 |
Organism | Human |
Amino acid sequence | >lcl|BSEQ0004597|Neuronal acetylcholine receptor subunit alpha-7 MRCSPGGVWLALAASLLHVSLQGEFQRKLYKELVKNYNPLERPVANDSQPLTVYFSLSLL QIMDVDEKNQVLTTNIWLQMSWTDHYLQWNVSEYPGVKTVRFPDGQIWKPDILLYNSADE RFDATFHTNVLVNSSGHCQYLPPGIFKSSCYIDVRWFPFDVQHCKLKFGSWSYGGWSLDL QMQEADISGYIPNGEWDLVGIPGKRSERFYECCKEPYPDVTFTVTMRRRTLYYGLNLLIP CVLISALALLVFLLPADSGEKISLGITVLLSLTVFMLLVAEIMPATSDSVPLIAQYFAST MIIVGLSVVVTVIVLQYHHHDPDGGKMPKWTRVILLNWCAWFLRMKRPGEDKVRPACQHK QRRCSLASVEMSAVAPPPASNGNLLYIGFRGLDGVHCVPTPDSGVVCGRMACSPTHDEHL LHGGQPPEGDPDLAKILEEVRYIANRFRCQDESEAVCSEWKFAACVVDRLCLMAFSVFTI ICTIGILMSAPNFVEAVSKDFA |
Number of residues | 502 |
Molecular Weight | 56448.925 |
Theoretical pI | 6.44 |
GO Classification |
Functions
protein homodimerization activity drug binding acetylcholine-activated cation-selective channel activity beta-amyloid binding acetylcholine-gated cation channel activity toxic substance binding acetylcholine binding acetylcholine receptor activity chloride channel regulator activity Processes
positive regulation of heart rate involved in baroreceptor response to decreased systemic arterial blood pressure negative regulation of tumor necrosis factor production neuronal action potential endocytosis B cell activation cation transmembrane transport behavioral response to nicotine memory behavioral response to ethanol cognition regulation of synaptic transmission, dopaminergic ion transmembrane transport negative regulation of inflammatory response negative regulation of interleukin-6 production ion transport positive regulation of angiogenesis response to hypoxia calcium ion transport activation of MAPK activity response to food signal transduction T cell activation associative learning generation of ovulation cycle rhythm response to nicotine dopamine biosynthetic process cellular calcium ion homeostasis regulation of norepinephrine secretion regulation of membrane potential synaptic transmission, cholinergic sperm motility synaptic transmission positive regulation of cell proliferation negative regulation of interleukin-1 beta production Components
cell junction dendritic spine membrane raft integral component of membrane neuron projection neuronal cell body postsynaptic density external side of plasma membrane cytoplasm presynaptic membrane acetylcholine-gated channel complex apical plasma membrane dendritic shaft asymmetric synapse synapse postsynaptic membrane plasma membrane axolemma growth cone |
General Function | Toxic substance binding |
Specific Function | After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. The channel is blocked by alpha-bungarotoxin. |
Transmembrane Regions | 231-255 262-280 296-317 470-490 |
GenBank Protein ID | 496607 |
UniProtKB ID | P36544 |
UniProtKB Entry Name | ACHA7_HUMAN |
Cellular Location | Cell junction |
Gene sequence | >lcl|BSEQ0020606|Neuronal acetylcholine receptor subunit alpha-7 (CHRNA7) ATGCGCTGCTCGCCGGGAGGCGTCTGGCTGGCGCTGGCCGCGTCGCTCCTGCACGTGTCC CTGCAAGGCGAGTTCCAGAGGAAGCTTTACAAGGAGCTGGTCAAGAACTACAATCCCTTG GAGAGGCCCGTGGCCAATGACTCGCAACCACTCACCGTCTACTTCTCCCTGAGCCTCCTG CAGATCATGGACGTGGATGAGAAGAACCAAGTTTTAACCACCAACATTTGGCTGCAAATG TCTTGGACAGATCACTATTTACAGTGGAATGTGTCAGAATATCCAGGGGTGAAGACTGTT CGTTTCCCAGATGGCCAGATTTGGAAACCAGACATTCTTCTCTATAACAGTGCTGATGAG CGCTTTGACGCCACATTCCACACTAACGTGTTGGTGAATTCTTCTGGGCATTGCCAGTAC CTGCCTCCAGGCATATTCAAGAGTTCCTGCTACATCGATGTACGCTGGTTTCCCTTTGAT GTGCAGCACTGCAAACTGAAGTTTGGGTCCTGGTCTTACGGAGGCTGGTCCTTGGATCTG CAGATGCAGGAGGCAGATATCAGTGGCTATATCCCCAATGGAGAATGGGACCTAGTGGGA ATCCCCGGCAAGAGGAGTGAAAGGTTCTATGAGTGCTGCAAAGAGCCCTACCCCGATGTC ACCTTCACAGTGACCATGCGCCGCAGGACGCTCTACTATGGCCTCAACCTGCTGATCCCC TGTGTGCTCATCTCCGCCCTCGCCCTGCTGGTGTTCCTGCTTCCTGCAGATTCCGGGGAG AAGATTTCCCTGGGGATAACAGTCTTACTCTCTCTTACCGTCTTCATGCTGCTCGTGGCT GAGATCATGCCCGCAACATCCGATTCGGTACCATTGATAGCCCAGTACTTCGCCAGCACC ATGATCATCGTGGGCCTCTCGGTGGTGGTGACAGTGATCGTGCTGCAGTACCACCACCAC GACCCCGACGGGGGCAAGATGCCCAAGTGGACCAGAGTCATCCTTCTGAACTGGTGCGCG TGGTTCCTGCGAATGAAGAGGCCCGGGGAGGACAAGGTGCGCCCGGCCTGCCAGCACAAG CAGCGGCGCTGCAGCCTGGCCAGTGTGGAGATGAGCGCCGTGGCGCCGCCGCCCGCCAGC AACGGGAACCTGCTGTACATCGGCTTCCGCGGCCTGGACGGCGTGCACTGTGTCCCGACC CCCGACTCTGGGGTAGTGTGTGGCCGCATGGCCTGCTCCCCCACGCACGATGAGCACCTC CTGCACGGCGGGCAACCCCCCGAGGGGGACCCGGACTTGGCCAAGATCCTGGAGGAGGTC CGCTACATTGCCAACCGCTTCCGCTGCCAGGACGAAAGCGAGGCGGTCTGCAGCGAGTGG AAGTTCGCCGCCTGTGTGGTGGACCGCCTGTGCCTCATGGCCTTCTCGGTCTTCACCATC ATCTGCACCATCGGCATCCTGATGTCGGCTCCCAACTTCGTGGAGGCCGTGTCCAAAGAC TTTGCGTAA |
GenBank Gene ID | X70297 |
GeneCard ID | None |
GenAtlas ID | CHRNA7 |
HGNC ID | HGNC:1960 |
Chromosome Location | 15 |
Locus | 15q14 |
References |
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