DNA-directed RNA polymerase II subunit RPB9


NameDNA-directed RNA polymerase II subunit RPB9
SynonymsDNA-directed RNA polymerase II subunit I RNA polymerase II 14.5 kDa subunit RNA polymerase II subunit B9 RPB14.5
Gene NamePOLR2I
OrganismHuman
Amino acid sequence
>lcl|BSEQ0019709|DNA-directed RNA polymerase II subunit RPB9
MEPDGTYEPGFVGIRFCQECNNMLYPKEDKENRILLYACRNCDYQQEADNSCIYVNKITH
EVDELTQIIADVSQDPTLPRTEDHPCQKCGHKEAVFFQSHSARAEDAMRLYYVCTAPHCG
HRWTE
Number of residues125
Molecular Weight14523.1
Theoretical pINone
GO Classification
Functions
    zinc ion binding
    DNA binding
    DNA-directed RNA polymerase activity
Processes
    nucleotide-excision repair
    gene silencing by RNA
    transcription from RNA polymerase II promoter
    mRNA splicing, via spliceosome
    piRNA metabolic process
    gene expression
    positive regulation of viral transcription
    transcription initiation from RNA polymerase II promoter
    RNA splicing
    transcription elongation from RNA polymerase II promoter
    maintenance of transcriptional fidelity during DNA-templated transcription elongation from RNA polymerase II promoter
    somatic stem cell population maintenance
    transcription-coupled nucleotide-excision repair
    DNA repair
    viral process
    7-methylguanosine mRNA capping
Components
    DNA-directed RNA polymerase II, core complex
    nucleolus
    nucleoplasm
    nucleus
General FunctionZinc ion binding
Specific FunctionDNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase II which synthesizes mRNA precursors and many functional non-coding RNAs. Pol II is the central component of the basal RNA polymerase II transcription machinery. It is composed of mobile elements that move relative to each other. RPB9 is part of the upper jaw surrounding the central large cleft and thought to grab the incoming DNA template (By similarity).
Transmembrane Regions
GenBank Protein ID
UniProtKB IDP36954
UniProtKB Entry NameRPB9_HUMAN
Cellular LocationNucleus
Gene sequence
>lcl|BSEQ0019710|DNA-directed RNA polymerase II subunit RPB9 (POLR2I)
ATGGAGCCCGACGGGACTTACGAGCCGGGCTTCGTGGGTATTCGCTTCTGCCAGGAATGT
AACAACATGCTGTACCCCAAGGAAGACAAGGAGAACCGCATTCTGCTCTACGCGTGCCGG
AACTGTGATTACCAGCAGGAGGCCGACAACAGCTGCATCTATGTCAACAAGATCACGCAC
GAAGTGGACGAACTGACCCAGATTATCGCCGACGTGTCCCAGGACCCCACGTTGCCGCGG
ACCGAGGACCACCCGTGCCAAAAGTGCGGCCACAAGGAGGCTGTGTTCTTCCAGTCACAC
AGTGCGCGGGCCGAGGACGCCATGCGCCTTTACTACGTGTGCACAGCCCCACACTGCGGC
CACCGCTGGACCGAGTGA
GenBank Gene ID
GeneCard IDNone
GenAtlas ID
HGNC IDHGNC:9196
Chromosome Location19
LocusNone
References
  1. Acker J, Wintzerith M, Vigneron M, Kedinger C: Structure of the gene encoding the 14.5 kDa subunit of human RNA polymerase II. Nucleic Acids Res. 1993 Nov 25;21(23):5345-50.[8265347 ]
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  3. Kershnar E, Wu SY, Chiang CM: Immunoaffinity purification and functional characterization of human transcription factor IIH and RNA polymerase II from clonal cell lines that conditionally express epitope-tagged subunits of the multiprotein complexes. J Biol Chem. 1998 Dec 18;273(51):34444-53.[9852112 ]
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