Phospholipid hydroperoxide glutathione peroxidase, mitochondrial
Name | Phospholipid hydroperoxide glutathione peroxidase, mitochondrial |
---|---|
Synonyms | 1.11.1.12 Glutathione peroxidase 4 GPx-4 GSHPx-4 PHGPx |
Gene Name | GPX4 |
Organism | Human |
Amino acid sequence | >lcl|BSEQ0037127|Phospholipid hydroperoxide glutathione peroxidase, mitochondrial MSLGRLCRLLKPALLCGALAAPGLAGTMCASRDDWRCARSMHEFSAKDIDGHMVNLDKYR GFVCIVTNVASQUGKTEVNYTQLVDLHARYAECGLRILAFPCNQFGKQEPGSNEEIKEFA AGYNVKFDMFSKICVNGDDAHPLWKWMKIQPKGKGILGNAIKWNFTKFLIDKNGCVVKRY GPMEEPLVIEKDLPHYF |
Number of residues | 197 |
Molecular Weight | 22174.52 |
Theoretical pI | 8.41 |
GO Classification |
Functions
glutathione peroxidase activity phospholipid-hydroperoxide glutathione peroxidase activity Processes
oxidation-reduction process multicellular organismal development arachidonic acid metabolic process lipoxygenase pathway phospholipid metabolic process response to oxidative stress spermatogenesis small molecule metabolic process chromatin organization Components
extracellular exosome nuclear envelope mitochondrion nucleus mitochondrial inner membrane cytosol |
General Function | Phospholipid-hydroperoxide glutathione peroxidase activity |
Specific Function | Protects cells against membrane lipid peroxidation and cell death. Required for normal sperm development and male fertility. Could play a major role in protecting mammals from the toxicity of ingested lipid hydroperoxides. Essential for embryonic development. Protects from radiation and oxidative damage. |
Transmembrane Regions | |
GenBank Protein ID | 825667 |
UniProtKB ID | P36969 |
UniProtKB Entry Name | GPX4_HUMAN |
Cellular Location | Mitochondrion |
Gene sequence | >lcl|BSEQ0010793|Phospholipid hydroperoxide glutathione peroxidase, mitochondrial (GPX4) ATGAGCCTCGGCCGCCTTTGCCGCCTACTGAAGCCGGCGCTGCTCTGTGGGGCTCTGGCC GCGCCTGGCCTGGCCGGGACCATGTGCGCGTCCCGGGACGACTGGCGCTGTGCGCGCTCC ATGCACGAGTTTTCCGCCAAGGACATCGACGGGCACATGGTTAACCTGGACAAGTACCGG GGCTTCGTGTGCATCGTCACCAACGTGGCCTCCCAGTGAGGCAAGACCGAAGTAAACTAC ACTCAGCTCGTCGACCTGCACGCCCGATACGCTGAGTGTGGTTTGCGGATCCTGGCCTTC CCGTGTAACCAGTTCGGGAAGCAGGAGCCAGGGAGTAACGAAGAGATCAAAGAGTTCGCC GCGGGCTACAACGTCAAATTCGATATGTTCAGCAAGATCTGCGTGAACGGGGACGACGCC CACCCGCTGTGGAAGTGGATGAAGATCCAACCCAAGGGCAAGGGCATCCTGGGAAATGCC ATCAAGTGGAACTTCACCAAGTTTGGACACCGTCTCTCCACAGTTCCTCATCGACAAGAA CGGCTGCGTGGTGAAGCGCTACGGACCCATGGAGGAGCCCCTGGTGATAGAGAAGGACCT GCCCCACTATTTCTAGCTCCACAAGTGTGTGGCCCCGCCCGAGCCCCTGCCCACGCCCTT GGAGCCTTCCACCGGCACTCATGA |
GenBank Gene ID | X71973 |
GeneCard ID | None |
GenAtlas ID | GPX4 |
HGNC ID | HGNC:4556 |
Chromosome Location | 19 |
Locus | 19p13.3 |
References |
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