Estradiol 17-beta-dehydrogenase 2
| Name | Estradiol 17-beta-dehydrogenase 2 |
|---|---|
| Synonyms | 1.1.1.62 17-beta-HSD 2 17-beta-hydroxysteroid dehydrogenase type 2 20 alpha-hydroxysteroid dehydrogenase 20-alpha-HSD E2DH EDH17B2 Microsomal 17-beta-hydroxysteroid dehydrogenase SDR9C2 Short chain dehydrogenase/reductase family 9C member 2 Testosterone 17-beta-dehydrogenase |
| Gene Name | HSD17B2 |
| Organism | Human |
| Amino acid sequence | >lcl|BSEQ0009867|Estradiol 17-beta-dehydrogenase 2 MSTFFSDTAWICLAVPTVLCGTVFCKYKKSSGQLWSWMVCLAGLCAVCLLILSPFWGLIL FSVSCFLMYTYLSGQELLPVDQKAVLVTGGDCGLGHALCKYLDELGFTVFAGVLNENGPG AEELRRTCSPRLSVLQMDITKPVQIKDAYSKVAAMLQDRGLWAVINNAGVLGFPTDGELL LMTDYKQCMAVNFFGTVEVTKTFLPLLRKSKGRLVNVSSMGGGAPMERLASYGSSKAAVT MFSSVMRLELSKWGIKVASIQPGGFLTNIAGTSDKWEKLEKDILDHLPAEVQEDYGQDYI LAQRNFLLLINSLASKDFSPVLRDIQHAILAKSPFAYYTPGKGAYLWICLAHYLPIGIYD YFAKRHFGQDKPMPRALRMPNYKKKAT |
| Number of residues | 387 |
| Molecular Weight | 42784.75 |
| Theoretical pI | 8.62 |
| GO Classification |
Functions
estradiol 17-beta-dehydrogenase activity 17-alpha,20-alpha-dihydroxypregn-4-en-3-one dehydrogenase activity testosterone dehydrogenase (NAD+) activity Processes
steroid biosynthetic process in utero embryonic development placenta development response to retinoic acid Components
endoplasmic reticulum membrane integral component of membrane |
| General Function | Testosterone dehydrogenase (nad+) activity |
| Specific Function | Capable of catalyzing the interconversion of testosterone and androstenedione, as well as estradiol and estrone. Also has 20-alpha-HSD activity. Uses NADH while EDH17B3 uses NADPH. |
| Transmembrane Regions | 4-24 |
| GenBank Protein ID | 306462 |
| UniProtKB ID | P37059 |
| UniProtKB Entry Name | DHB2_HUMAN |
| Cellular Location | Membrane |
| Gene sequence | >lcl|BSEQ0009868|Estradiol 17-beta-dehydrogenase 2 (HSD17B2) ATGAGCACTTTCTTCTCGGACACAGCATGGATCTGCCTGGCTGTCCCCACAGTACTATGT GGGACAGTATTTTGCAAATACAAGAAGAGCTCAGGGCAGCTGTGGAGCTGGATGGTCTGC CTGGCAGGCCTCTGTGCAGTCTGCCTGCTCATCCTGTCCCCTTTTTGGGGCTTGATCCTC TTCTCGGTGTCATGCTTCCTCATGTATACTTACTTATCTGGCCAAGAATTGTTACCTGTG GATCAGAAGGCAGTCCTGGTGACAGGTGGTGATTGCGGGCTTGGCCATGCTTTGTGCAAG TATCTGGATGAGCTGGGCTTCACGGTATTTGCCGGAGTTTTGAATGAAAATGGCCCAGGA GCTGAGGAATTGCGAAGAACCTGCTCTCCGCGCCTCTCGGTGCTCCAAATGGACATCACG AAGCCAGTGCAGATAAAAGATGCTTACAGCAAGGTTGCAGCAATGCTGCAGGACAGAGGA CTGTGGGCTGTGATCAACAATGCTGGGGTGCTTGGCTTTCCAACTGATGGGGAGCTTCTT CTTATGACTGACTACAAACAATGCATGGCCGTGAACTTCTTTGGAACTGTGGAGGTCACA AAGACGTTTTTGCCTCTTCTTAGAAAATCCAAAGGGAGGCTGGTGAATGTCAGCAGCATG GGAGGAGGGGCCCCAATGGAAAGGCTGGCATCTTATGGCTCATCAAAGGCGGCTGTGACC ATGTTCTCATCAGTTATGAGACTGGAGCTTTCCAAGTGGGGAATTAAAGTTGCTTCCATC CAACCTGGAGGCTTCCTAACAAATATCGCAGGCACCAGTGACAAGTGGGAAAAGCTGGAG AAGGACATTCTGGACCACCTCCCCGCTGAGGTACAGGAAGACTACGGCCAGGACTACATC TTAGCACAGCGGAATTTCCTCCTATTGATCAACTCGTTAGCCAGCAAGGACTTCTCTCCG GTGCTGCGGGACATCCAGCATGCTATCTTGGCGAAGAGCCCTTTTGCCTATTACACGCCA GGGAAAGGCGCTTACTTGTGGATCTGCCTTGCTCACTATTTGCCTATTGGCATATATGAT TACTTTGCTAAAAGACATTTTGGCCAAGACAAGCCCATGCCCAGAGCTCTAAGAATGCCT AACTACAAGAAAAAGGCCACCTAG |
| GenBank Gene ID | L11708 |
| GeneCard ID | None |
| GenAtlas ID | HSD17B2 |
| HGNC ID | HGNC:5211 |
| Chromosome Location | 16 |
| Locus | 16q24.1-q24.2 |
| References |
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Related FRC
| FRCD ID | Name | Exact Mass | Structure |
|---|---|---|---|
Genistein |
270.24 |