Estradiol 17-beta-dehydrogenase 2
Name | Estradiol 17-beta-dehydrogenase 2 |
---|---|
Synonyms | 1.1.1.62 17-beta-HSD 2 17-beta-hydroxysteroid dehydrogenase type 2 20 alpha-hydroxysteroid dehydrogenase 20-alpha-HSD E2DH EDH17B2 Microsomal 17-beta-hydroxysteroid dehydrogenase SDR9C2 Short chain dehydrogenase/reductase family 9C member 2 Testosterone 17-beta-dehydrogenase |
Gene Name | HSD17B2 |
Organism | Human |
Amino acid sequence | >lcl|BSEQ0009867|Estradiol 17-beta-dehydrogenase 2 MSTFFSDTAWICLAVPTVLCGTVFCKYKKSSGQLWSWMVCLAGLCAVCLLILSPFWGLIL FSVSCFLMYTYLSGQELLPVDQKAVLVTGGDCGLGHALCKYLDELGFTVFAGVLNENGPG AEELRRTCSPRLSVLQMDITKPVQIKDAYSKVAAMLQDRGLWAVINNAGVLGFPTDGELL LMTDYKQCMAVNFFGTVEVTKTFLPLLRKSKGRLVNVSSMGGGAPMERLASYGSSKAAVT MFSSVMRLELSKWGIKVASIQPGGFLTNIAGTSDKWEKLEKDILDHLPAEVQEDYGQDYI LAQRNFLLLINSLASKDFSPVLRDIQHAILAKSPFAYYTPGKGAYLWICLAHYLPIGIYD YFAKRHFGQDKPMPRALRMPNYKKKAT |
Number of residues | 387 |
Molecular Weight | 42784.75 |
Theoretical pI | 8.62 |
GO Classification |
Functions
estradiol 17-beta-dehydrogenase activity 17-alpha,20-alpha-dihydroxypregn-4-en-3-one dehydrogenase activity testosterone dehydrogenase (NAD+) activity Processes
steroid biosynthetic process in utero embryonic development placenta development response to retinoic acid Components
endoplasmic reticulum membrane integral component of membrane |
General Function | Testosterone dehydrogenase (nad+) activity |
Specific Function | Capable of catalyzing the interconversion of testosterone and androstenedione, as well as estradiol and estrone. Also has 20-alpha-HSD activity. Uses NADH while EDH17B3 uses NADPH. |
Transmembrane Regions | 4-24 |
GenBank Protein ID | 306462 |
UniProtKB ID | P37059 |
UniProtKB Entry Name | DHB2_HUMAN |
Cellular Location | Membrane |
Gene sequence | >lcl|BSEQ0009868|Estradiol 17-beta-dehydrogenase 2 (HSD17B2) ATGAGCACTTTCTTCTCGGACACAGCATGGATCTGCCTGGCTGTCCCCACAGTACTATGT GGGACAGTATTTTGCAAATACAAGAAGAGCTCAGGGCAGCTGTGGAGCTGGATGGTCTGC CTGGCAGGCCTCTGTGCAGTCTGCCTGCTCATCCTGTCCCCTTTTTGGGGCTTGATCCTC TTCTCGGTGTCATGCTTCCTCATGTATACTTACTTATCTGGCCAAGAATTGTTACCTGTG GATCAGAAGGCAGTCCTGGTGACAGGTGGTGATTGCGGGCTTGGCCATGCTTTGTGCAAG TATCTGGATGAGCTGGGCTTCACGGTATTTGCCGGAGTTTTGAATGAAAATGGCCCAGGA GCTGAGGAATTGCGAAGAACCTGCTCTCCGCGCCTCTCGGTGCTCCAAATGGACATCACG AAGCCAGTGCAGATAAAAGATGCTTACAGCAAGGTTGCAGCAATGCTGCAGGACAGAGGA CTGTGGGCTGTGATCAACAATGCTGGGGTGCTTGGCTTTCCAACTGATGGGGAGCTTCTT CTTATGACTGACTACAAACAATGCATGGCCGTGAACTTCTTTGGAACTGTGGAGGTCACA AAGACGTTTTTGCCTCTTCTTAGAAAATCCAAAGGGAGGCTGGTGAATGTCAGCAGCATG GGAGGAGGGGCCCCAATGGAAAGGCTGGCATCTTATGGCTCATCAAAGGCGGCTGTGACC ATGTTCTCATCAGTTATGAGACTGGAGCTTTCCAAGTGGGGAATTAAAGTTGCTTCCATC CAACCTGGAGGCTTCCTAACAAATATCGCAGGCACCAGTGACAAGTGGGAAAAGCTGGAG AAGGACATTCTGGACCACCTCCCCGCTGAGGTACAGGAAGACTACGGCCAGGACTACATC TTAGCACAGCGGAATTTCCTCCTATTGATCAACTCGTTAGCCAGCAAGGACTTCTCTCCG GTGCTGCGGGACATCCAGCATGCTATCTTGGCGAAGAGCCCTTTTGCCTATTACACGCCA GGGAAAGGCGCTTACTTGTGGATCTGCCTTGCTCACTATTTGCCTATTGGCATATATGAT TACTTTGCTAAAAGACATTTTGGCCAAGACAAGCCCATGCCCAGAGCTCTAAGAATGCCT AACTACAAGAAAAAGGCCACCTAG |
GenBank Gene ID | L11708 |
GeneCard ID | None |
GenAtlas ID | HSD17B2 |
HGNC ID | HGNC:5211 |
Chromosome Location | 16 |
Locus | 16q24.1-q24.2 |
References |
|
Related FRC
FRCD ID | Name | Exact Mass | Structure |
---|---|---|---|
Genistein |
270.24 |