Alcohol dehydrogenase class 4 mu/sigma chain
| Name | Alcohol dehydrogenase class 4 mu/sigma chain |
|---|---|
| Synonyms | 1.1.1.1 Alcohol dehydrogenase class IV mu/sigma chain Gastric alcohol dehydrogenase Retinol dehydrogenase |
| Gene Name | ADH7 |
| Organism | Human |
| Amino acid sequence | >lcl|BSEQ0037036|Alcohol dehydrogenase class 4 mu/sigma chain MFAEIQIQDKDRMGTAGKVIKCKAAVLWEQKQPFSIEEIEVAPPKTKEVRIKILATGICR TDDHVIKGTMVSKFPVIVGHEATGIVESIGEGVTTVKPGDKVIPLFLPQCRECNACRNPD GNLCIRSDITGRGVLADGTTRFTCKGKPVHHFMNTSTFTEYTVVDESSVAKIDDAAPPEK VCLIGCGFSTGYGAAVKTGKVKPGSTCVVFGLGGVGLSVIMGCKSAGASRIIGIDLNKDK FEKAMAVGATECISPKDSTKPISEVLSEMTGNNVGYTFEVIGHLETMIDALASCHMNYGT SVVVGVPPSAKMLTYDPMLLFTGRTWKGCVFGGLKSRDDVPKLVTEFLAKKFDLDQLITH VLPFKKISEGFELLNSGQSIRTVLTF |
| Number of residues | 386 |
| Molecular Weight | 41480.985 |
| Theoretical pI | 8.08 |
| GO Classification |
Functions
retinol binding zinc ion binding alcohol dehydrogenase (NAD) activity alcohol dehydrogenase activity, zinc-dependent ethanol binding retinol dehydrogenase activity aldehyde oxidase activity receptor antagonist activity Processes
xenobiotic metabolic process extracellular negative regulation of signal transduction fatty acid omega-oxidation retinoid metabolic process response to bacterium response to ethanol retinoic acid metabolic process retinol metabolic process small molecule metabolic process oxidation-reduction process ethanol catabolic process ethanol oxidation Components
extracellular region cytosol |
| General Function | Zinc ion binding |
| Specific Function | Could function in retinol oxidation for the synthesis of retinoic acid, a hormone important for cellular differentiation. Medium-chain (octanol) and aromatic (m-nitrobenzaldehyde) compounds are the best substrates. Ethanol is not a good substrate but at the high ethanol concentrations reached in the digestive tract, it plays a role in the ethanol oxidation and contributes to the first pass ethanol metabolism. |
| Transmembrane Regions | |
| GenBank Protein ID | 516618 |
| UniProtKB ID | P40394 |
| UniProtKB Entry Name | ADH7_HUMAN |
| Cellular Location | Cytoplasm |
| Gene sequence | >lcl|BSEQ0010367|Alcohol dehydrogenase class 4 mu/sigma chain (ADH7) ATGTTTGCAGAAATACAGATCCAAGACAAAGACAGGATGGGCACTGCTGGAAAAGTTATT AAATGCAAAGCAGCTGTGCTTTGGGAGCAGAAGCAACCCTTCTCCATTGAGGAAATAGAA GTTGCCCCACCAAAGACTAAAGAAGTTCGCATTAAGATTTTGGCCACAGGAATCTGTCGC ACAGATGACCATGTGATAAAAGGAACAATGGTGTCCAAGTTTCCAGTGATTGTGGGACAT GAGGCAACTGGGATTGTAGAGAGCATTGGAGAAGGAGTGACTACAGTGAAACCAGGTGAC AAAGTCATCCCTCTCTTTCTGCCACAATGTAGAGAATGCAATGCTTGTCGCAACCCAGAT GGCAACCTTTGCATTAGGAGCGATATTACTGGTCGTGGAGTACTGGCTGATGGCACCACC AGATTTACATGCAAGGGCAAACCAGTCCACCACTTCATGAACACCAGTACATTTACCGAG TACACAGTGGTGGATGAATCTTCTGTTGCTAAGATTGATGATGCAGCTCCTCCTGAGAAA GTCTGTTTAATTGGCTGTGGGTTTTCCACTGGATATGGCGCTGCTGTTAAAACTGGCAAG GTCAAACCTGGTTCCACTTGCGTCGTCTTTGGCCTGGGAGGAGTTGGCCTGTCAGTCATC ATGGGCTGTAAGTCAGCTGGTGCATCTAGGATCATTGGGATTGACCTCAACAAAGACAAA TTTGAGAAGGCCATGGCTGTAGGTGCCACTGAGTGTATCAGTCCCAAGGACTCTACCAAA CCCATCAGTGAGGTGCTGTCAGAAATGACAGGCAACAACGTGGGATACACCTTTGAAGTT ATTGGGCATCTTGAAACCATGATTGATGCCCTGGCATCCTGCCACATGAACTATGGGACC AGCGTGGTTGTAGGAGTTCCTCCATCAGCCAAGATGCTCACCTATGACCCGATGTTGCTC TTCACTGGACGCACATGGAAGGGATGTGTCTTTGGAGGTTTGAAAAGCAGAGATGATGTC CCAAAACTAGTGACTGAGTTCCTGGCAAAGAAATTTGACCTGGACCAGTTGATAACTCAT GTTTTACCATTTAAAAAAATCAGTGAAGGATTTGAGCTGCTCAATTCAGGACAAAGCATT CGAACGGTCCTGACGTTTTGA |
| GenBank Gene ID | L33179 |
| GeneCard ID | None |
| GenAtlas ID | ADH7 |
| HGNC ID | HGNC:256 |
| Chromosome Location | 4 |
| Locus | 4q23-q24 |
| References |
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Related FRC
| FRCD ID | Name | Exact Mass | Structure |
|---|---|---|---|
Trichloroethylene |
131.38 |
||
Tetrabutyltin |
347.174 |
||
Triphenyltin |
350.028 |
||
Azocyclotin |
436.231 |
||
Ethanol |
46.07 |
||
Hydroxytriphenylstannane |
367.035 |