Malate dehydrogenase, cytoplasmic


NameMalate dehydrogenase, cytoplasmic
Synonyms1.1.1.37 Cytosolic malate dehydrogenase Diiodophenylpyruvate reductase MDHA
Gene NameMDH1
OrganismHuman
Amino acid sequence
>lcl|BSEQ0037050|Malate dehydrogenase, cytoplasmic
MSEPIRVLVTGAAGQIAYSLLYSIGNGSVFGKDQPIILVLLDITPMMGVLDGVLMELQDC
ALPLLKDVIATDKEDVAFKDLDVAILVGSMPRREGMERKDLLKANVKIFKSQGAALDKYA
KKSVKVIVVGNPANTNCLTASKSAPSIPKENFSCLTRLDHNRAKAQIALKLGVTANDVKN
VIIWGNHSSTQYPDVNHAKVKLQGKEVGVYEALKDDSWLKGEFVTTVQQRGAAVIKARKL
SSAMSAAKAICDHVRDIWFGTPEGEFVSMGVISDGNSYGVPDDLLYSFPVVIKNKTWKFV
EGLPINDFSREKMDLTAKELTEEKESAFEFLSSA
Number of residues334
Molecular Weight36425.795
Theoretical pI7.45
GO Classification
Functions
    malic enzyme activity
    diiodophenylpyruvate reductase activity
    L-malate dehydrogenase activity
    NAD binding
Processes
    xenophagy
    malate metabolic process
    gluconeogenesis
    mitophagy in response to mitochondrial depolarization
    small molecule metabolic process
    NADH metabolic process
    carbohydrate metabolic process
    tricarboxylic acid cycle
    glucose metabolic process
    oxaloacetate metabolic process
    positive regulation of defense response to virus by host
Components
    extracellular space
    cytosol
    centrosome
    extracellular exosome
    cytoplasm
    mitochondrion
    myelin sheath
General FunctionNad binding
Specific FunctionNone
Transmembrane Regions
GenBank Protein ID1255604
UniProtKB IDP40925
UniProtKB Entry NameMDHC_HUMAN
Cellular LocationCytoplasm
Gene sequence
>lcl|BSEQ0021650|Malate dehydrogenase, cytoplasmic (MDH1)
ATGCGACGCTGCAGCTATTTTCCAAAGGACGTTACGGTGTTTGATAAGGACGATAAGTCT
GAACCAATCAGAGTCCTTGTGACTGGAGCAGCTGGTCAAATTGCATATTCACTGCTGTAC
AGTATTGGAAATGGATCTGTCTTTGGTAAAGATCAGCCTATAATTCTTGTGCTGTTGGAT
ATCACCCCCATGATGGGTGTCCTGGACGGTGTCCTAATGGAACTGCAAGACTGTGCCCTT
CCCCTCCTGAAAGATGTCATCGCAACAGATAAAGAAGACGTTGCCTTCAAAGACCTGGAT
GTGGCCATTCTTGTGGGCTCCATGCCAAGAAGGGAAGGCATGGAGAGAAAAGATTTACTG
AAAGCAAATGTGAAAATCTTCAAATCCCAGGGTGCAGCCTTAGATAAATACGCCAAGAAG
TCAGTTAAGGTTATTGTTGTGGGTAATCCAGCCAATACCAACTGCCTGACTGCTTCCAAG
TCAGCTCCATCCATCCCCAAGGAGAACTTCAGTTGCTTGACTCGTTTGGATCACAACCGA
GCTAAAGCTCAAATTGCTCTTAAACTTGGTGTGACTGCTAATGATGTAAAGAATGTCATT
ATCTGGGGAAACCATTCCTCGACTCAGTATCCAGATGTCAACCATGCCAAGGTGAAATTG
CAAGGAAAGGAAGTTGGTGTTTATGAAGCTCTGAAAGATGACAGCTGGCTCAAGGGAGAA
TTTGTCACGACTGTGCAGCAGCGTGGCGCTGCTGTCATCAAGGCTCGAAAACTATCCAGT
GCCATGTCTGCTGCAAAAGCCATCTGTGACCACGTCAGGGACATCTGGTTTGGAACCCCA
GAGGGAGAGTTTGTGTCCATGGGTGTTATCTCTGATGGCAACTCCTATGGTGTTCCTGAT
GATCTGCTCTACTCATTCCCTGTTGTAATCAAGAATAAGACCTGGAAGTTTGTTGAAGGT
CTCCCTATTAATGATTTCTCACGTGAGAAGATGGATCTTACTGCAAAGGAACTGACAGAA
GAAAAAGAAAGTGCTTTTGAATTTCTTTCCTCTGCCTGA
GenBank Gene IDD55654
GeneCard IDNone
GenAtlas IDMDH1
HGNC IDHGNC:6970
Chromosome Location2
Locus2p13.3
References
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