Kappa-type opioid receptor
Name | Kappa-type opioid receptor |
---|---|
Synonyms | K-OR-1 OPRK |
Gene Name | OPRK1 |
Organism | Human |
Amino acid sequence | >lcl|BSEQ0001260|Kappa-type opioid receptor MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPV IITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYL MNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINI CIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVL IIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALG STSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRV RNTVQDPAYLRDIDGMNKPV |
Number of residues | 380 |
Molecular Weight | 42644.665 |
Theoretical pI | 7.79 |
GO Classification |
Functions
dynorphin receptor activity opioid receptor activity neuropeptide binding Processes
cellular response to lipopolysaccharide estrous cycle adenylate cyclase-inhibiting opioid receptor signaling pathway response to insulin regulation of energy homeostasis positive regulation of locomotion maternal behavior immune response positive regulation of dopamine secretion regulation of saliva secretion response to ethanol defense response to virus phospholipase C-activating G-protein coupled receptor signaling pathway regulation of sensory perception of pain positive regulation of p38MAPK cascade locomotory behavior response to morphine neuropeptide signaling pathway sensory perception of temperature stimulus positive regulation of potassium ion transmembrane transport synaptic transmission response to acrylamide response to estrogen behavioral response to cocaine response to radiation behavior sensory perception negative regulation of luteinizing hormone secretion sensory perception of pain eating behavior regulation of aerobic respiration adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway opioid receptor signaling pathway Components
integral component of plasma membrane axon terminus dendrite synapse plasma membrane neuron projection perikaryon integral component of membrane |
General Function | Opioid receptor activity |
Specific Function | G-protein coupled opioid receptor that functions as receptor for endogenous alpha-neoendorphins and dynorphins, but has low affinity for beta-endorphins. Also functions as receptor for various synthetic opioids and for the psychoactive diterpene salvinorin A. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling leads to the inhibition of adenylate cyclase activity. Inhibits neurotransmitter release by reducing calcium ion currents and increasing potassium ion conductance. Plays a role in the perception of pain. Plays a role in mediating reduced physical activity upon treatment with synthetic opioids. Plays a role in the regulation of salivation in response to synthetic opioids. May play a role in arousal and regulation of autonomic and neuroendocrine functions. |
Transmembrane Regions | 58-85 96-119 133-154 174-196 223-247 275-296 312-333 |
GenBank Protein ID | 532060 |
UniProtKB ID | P41145 |
UniProtKB Entry Name | OPRK_HUMAN |
Cellular Location | Cell membrane |
Gene sequence | >lcl|BSEQ0021645|Kappa-type opioid receptor (OPRK1) ATGGACTCCCCGATCCAGATCTTCCGCGGGGAGCCGGGCCCTACCTGCGCCCCGAGCGCC TGCCTGCCCCCCAACAGCAGCGCCTGGTTTCCCGGCTGGGCCGAGCCCGACAGCAACGGC AGCGCCGGCTCGGAGGACGCGCAGCTGGAGCCCGCGCACATCTCCCCGGCCATCCCGGTC ATCATCACGGCGGTCTACTCCGTAGTGTTCGTCGTGGGCTTGGTGGGCAACTCGCTGGTC ATGTTCGTGATCATCCGATACACAAAGATGAAGACAGCAACCAACATTTACATATTTAAC CTGGCTTTGGCAGATGCTTTAGTTACTACAACCATGCCCTTTCAGAGTACGGTCTACTTG ATGAATTCCTGGCCTTTTGGGGATGTGCTGTGCAAGATAGTAATTTCCATTGATTACTAC AACATGTTCACCAGCATCTTCACCTTGACCATGATGAGCGTGGACCGCTACATTGCCGTG TGCCACCCCGTGAAGGCTTTGGACTTCCGCACACCCTTGAAGGCAAAGATCATCAATATC TGCATCTGGCTGCTGTCGTCATCTGTTGGCATCTCTGCAATAGTCCTTGGAGGCACCAAA GTCAGGGAAGACGTCGATGTCATTGAGTGCTCCTTGCAGTTCCCAGATGATGACTACTCC TGGTGGGACCTCTTCATGAAGATCTGCGTCTTCATCTTTGCCTTCGTGATCCCTGTCCTC ATCATCATCGTCTGCTACACCCTGATGATCCTGCGTCTCAAGAGCGTCCGGCTCCTTTCT GGCTCCCGAGAGAAAGATCGCAACCTGCGTAGGATCACCAGACTGGTCCTGGTGGTGGTG GCAGTCTTCGTCGTCTGCTGGACTCCCATTCACATATTCATCCTGGTGGAGGCTCTGGGG AGCACCTCCCACAGCACAGCTGCTCTCTCCAGCTATTACTTCTGCATCGCCTTAGGCTAT ACCAACAGTAGCCTGAATCCCATTCTCTACGCCTTTCTTGATGAAAACTTCAAGCGGTGT TTCCGGGACTTCTGCTTTCCACTGAAGATGAGGATGGAGCGGCAGAGCACTAGCAGAGTC CGAAATACAGTTCAGGATCCTGCTTACCTGAGGGACATCGATGGGATGAATAAACCAGTA TGA |
GenBank Gene ID | U11053 |
GeneCard ID | None |
GenAtlas ID | OPRK1 |
HGNC ID | HGNC:8154 |
Chromosome Location | 8 |
Locus | 8q11.2 |
References |
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Related FRC
FRCD ID | Name | Exact Mass | Structure |
---|---|---|---|
Nantenine |
339.391 |
||
Aripiprazole |
448.388 |
||
Codeine |
299.4 |
||
Mirtazapine |
265.36 |
||
Dextromethorphan |
271.404 |
||
Salvinorin A |
432.469 |
||
Progesterone |
314.469 |