Nociceptin receptor
Name | Nociceptin receptor |
---|---|
Synonyms | Kappa-type 3 opioid receptor KOR-3 OOR ORL1 Orphanin FQ receptor |
Gene Name | OPRL1 |
Organism | Human |
Amino acid sequence | >lcl|BSEQ0004671|Nociceptin receptor MEPLFPAPFWEVIYGSHLQGNLSLLSPNHSLLPPHLLLNASHGAFLPLGLKVTIVGLYLA VCVGGLLGNCLVMYVILRHTKMKTATNIYIFNLALADTLVLLTLPFQGTDILLGFWPFGN ALCKTVIAIDYYNMFTSTFTLTAMSVDRYVAICHPIRALDVRTSSKAQAVNVAIWALASV VGVPVAIMGSAQVEDEEIECLVEIPTPQDYWGPVFAICIFLFSFIVPVLVISVCYSLMIR RLRGVRLLSGSREKDRNLRRITRLVLVVVAVFVGCWTPVQVFVLAQGLGVQPSSETAVAI LRFCTALGYVNSCLNPILYAFLDENFKACFRKFCCASALRRDVQVSDRVRSIAKDVALAC KTSETVPRPA |
Number of residues | 370 |
Molecular Weight | 40692.775 |
Theoretical pI | 8.43 |
GO Classification |
Functions
neuropeptide binding G-protein coupled receptor activity nociceptin receptor activity Processes
negative regulation of cAMP biosynthetic process positive regulation of cytosolic calcium ion concentration negative regulation of voltage-gated calcium channel activity positive regulation of protein phosphorylation eating behavior response to estradiol opioid receptor signaling pathway estrous cycle sensory perception of pain positive regulation of urine volume adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway locomotor rhythm neuropeptide signaling pathway negative regulation of blood pressure synaptic transmission positive regulation of gastric acid secretion sensory perception regulation of sensory perception of pain Components
cytosol integral component of plasma membrane neuron projection plasma membrane cytoplasmic membrane-bounded vesicle |
General Function | Nociceptin receptor activity |
Specific Function | G-protein coupled opioid receptor that functions as receptor for the endogenous neuropeptide nociceptin. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling via G proteins mediates inhibition of adenylate cyclase activity and calcium channel activity. Arrestins modulate signaling via G proteins and mediate the activation of alternative signaling pathways that lead to the activation of MAP kinases. Plays a role in modulating nociception and the perception of pain. Plays a role in the regulation of locomotor activity by the neuropeptide nociceptin. |
Transmembrane Regions | 49-74 88-109 125-146 166-188 212-236 265-285 301-322 |
GenBank Protein ID | |
UniProtKB ID | P41146 |
UniProtKB Entry Name | OPRX_HUMAN |
Cellular Location | Cell membrane |
Gene sequence | >lcl|BSEQ0016773|Nociceptin receptor (OPRL1) ATGGAGCCCCTCTTCCCCGCGCCGTTCTGGGAGGTTATCTACGGCAGCCACCTTCAGGGC AACCTGTCCCTCCTGAGCCCCAACCACAGTCTGCTGCCCCCGCATCTGCTGCTCAATGCC AGCCACGGCGCCTTCCTGCCCCTCGGGCTCAAGGTCACCATCGTGGGGCTCTACCTGGCC GTGTGTGTCGGAGGGCTCCTGGGGAACTGCCTTGTCATGTACGTCATCCTCAGGCACACC AAAATGAAGACAGCCACCAATATTTACATCTTTAACCTGGCCCTGGCCGACACTCTGGTC CTGCTGACGCTGCCCTTCCAGGGCACGGACATCCTCCTGGGCTTCTGGCCGTTTGGGAAT GCGCTGTGCAAGACAGTCATTGCCATTGACTACTACAACATGTTCACCAGCACCTTCACC CTAACTGCCATGAGTGTGGATCGCTATGTAGCCATCTGCCACCCCATCCGTGCCCTCGAC GTCCGCACGTCCAGCAAAGCCCAGGCTGTCAATGTGGCCATCTGGGCCCTGGCCTCTGTT GTCGGTGTTCCCGTTGCCATCATGGGCTCGGCACAGGTCGAGGATGAAGAGATCGAGTGC CTGGTGGAGATCCCTACCCCTCAGGATTACTGGGGCCCGGTGTTTGCCATCTGCATCTTC CTCTTCTCCTTCATCGTCCCCGTGCTCGTCATCTCTGTCTGCTACAGCCTCATGATCCGG CGGCTCCGTGGAGTCCGCCTGCTCTCGGGCTCCCGAGAGAAGGACCGGAACCTGCGGCGC ATCACTCGGCTGGTGCTGGTGGTAGTGGCTGTGTTCGTGGGCTGCTGGACGCCTGTCCAG GTCTTCGTGCTGGCCCAAGGGCTGGGGGTTCAGCCGAGCAGCGAGACTGCCGTGGCCATT CTGCGCTTCTGCACGGCCCTGGGCTACGTCAACAGCTGCCTCAACCCCATCCTCTACGCC TTCCTGGATGAGAACTTCAAGGCCTGCTTCCGCAAGTTCTGCTGTGCATCTGCCCTGCGC CGGGACGTGCAGGTGTCTGACCGCGTGCGCAGCATTGCCAAGGACGTGGCCCTGGCCTGC AAGACCTCTGAGACGGTACCGCGGCCCGCATGA |
GenBank Gene ID | X77130 |
GeneCard ID | None |
GenAtlas ID | OPRL1 |
HGNC ID | HGNC:8155 |
Chromosome Location | 20 |
Locus | 20q13.33 |
References |
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Related FRC
FRCD ID | Name | Exact Mass | Structure |
---|---|---|---|
Captan |
300.578 |
||
Captafol |
349.047 |
||
Thiram |
240.416 |
||
Folpet |
296.546 |
||
Maneb |
265.284 |
||
Mercuric chloride |
271.492 |