Tyrosine-protein kinase CSK

NameTyrosine-protein kinase CSK
Synonyms2.7.10.2 C-Src kinase Protein-tyrosine kinase CYL
Gene NameCSK
OrganismHuman
Amino acid sequence
>lcl|BSEQ0021663|Tyrosine-protein kinase CSK
MSAIQAAWPSGTECIAKYNFHGTAEQDLPFCKGDVLTIVAVTKDPNWYKAKNKVGREGII
PANYVQKREGVKAGTKLSLMPWFHGKITREQAERLLYPPETGLFLVRESTNYPGDYTLCV
SCDGKVEHYRIMYHASKLSIDEEVYFENLMQLVEHYTSDADGLCTRLIKPKVMEGTVAAQ
DEFYRSGWALNMKELKLLQTIGKGEFGDVMLGDYRGNKVAVKCIKNDATAQAFLAEASVM
TQLRHSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCE
AMEYLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEASSTQDTGKLPVKWTAPEALRE
KKFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKGYKMDAPDGCPPAVYEVMK
NCWHLDAAMRPSFLQLREQLEHIKTHELHL
Number of residues450
Molecular Weight50703.975
Theoretical pI7.07
GO Classification
Functions
    metal ion binding
non-membrane spanning protein tyrosine kinase activity
protein kinase A catalytic subunit binding
identical protein binding
ATP binding
protein C-terminus binding
protein tyrosine kinase activity
receptor binding
Processes
    negative regulation of kinase activity
epidermal growth factor receptor signaling pathway
T cell costimulation
adherens junction organization
innate immune response
T cell receptor signaling pathway
morphogenesis of an epithelium
peptidyl-tyrosine autophosphorylation
adaptive immune response
platelet activation
regulation of cell proliferation
oligodendrocyte differentiation
negative regulation of Golgi to plasma membrane protein transport
negative regulation of ERK1 and ERK2 cascade
regulation of Fc receptor mediated stimulatory signaling pathway
negative regulation of cell proliferation
cellular response to peptide hormone stimulus
negative regulation of low-density lipoprotein particle clearance
protein phosphorylation
negative regulation of bone resorption
transmembrane receptor protein tyrosine kinase signaling pathway
negative regulation of interleukin-6 production
brain development
blood coagulation
negative regulation of phagocytosis
cell differentiation
positive regulation of MAP kinase activity
regulation of cytokine production
cell migration
Components
    cell-cell junction
plasma membrane
cytosol
extracellular exosome
cytoplasm
extrinsic component of cytoplasmic side of plasma membrane
membrane raft
General FunctionReceptor binding
Specific FunctionNon-receptor tyrosine-protein kinase that plays an important role in the regulation of cell growth, differentiation, migration and immune response. Phosphorylates tyrosine residues located in the C-terminal tails of Src-family kinases (SFKs) including LCK, SRC, HCK, FYN, LYN or YES1. Upon tail phosphorylation, Src-family members engage in intramolecular interactions between the phosphotyrosine tail and the SH2 domain that result in an inactive conformation. To inhibit SFKs, CSK is recruited to the plasma membrane via binding to transmembrane proteins or adapter proteins located near the plasma membrane. Suppresses signaling by various surface receptors, including T-cell receptor (TCR) and B-cell receptor (BCR) by phosphorylating and maintaining inactive several positive effectors such as FYN or LCK.
Transmembrane Regions
GenBank Protein ID30315
UniProtKB IDP41240
UniProtKB Entry NameCSK_HUMAN
Cellular LocationCytoplasm
Gene sequence
>lcl|BSEQ0021664|Tyrosine-protein kinase CSK (CSK)
ATGTCAGCAATACAGGCCGCCTGGCCATCCGGTACAGAATGTATTGCCAAGTACAACTTC
CACGGCACTGCCGAGCAGGACCTGCCCTTCTGCAAAGGAGACGTGCTCACCATTGTGGCC
GTCACCAAGGACCCCAACTGGTACAAAGCCAAAAACAAGGTGGGCCGTGAGGGCATCATC
CCAGCCAACTACGTCCAGAAGCGGGAGGGCGTGAAGGCGGGTACCAAACTCAGCCTCATG
CCTTGGTTCCACGGCAAGATCACACGGGAGCAGGCTGAGCGGCTTCTGTACCCGCCGGAG
ACAGGCCTGTTCCTGGTGCGGGAGAGCACCAACTACCCCGGAGACTACACGCTGTGCGTG
AGCTGCGACGGCAAGGTGGAGCACTACCGCATCATGTACCATGCCAGCAAGCTCAGCATC
GACGAGGAGGTGTACTTTGAGAACCTCATGCAGCTGGTGGAGCACTACACCTCAGACGCA
GATGGACTCTGTACGCGCCTCATTAAACCAAAGGTCATGGAGGGCACAGTGGCGGCCCAG
GATGAGTTCTACCGCAGCGGCTGGGCCCTGAACATGAAGGAGCTGAAGCTGCTGCAGACC
ATCGGGAAGGGGGAGTTCGGAGACGTGATGCTGGGCGATTACCGAGGGAACAAAGTCGCC
GTCAAGTGCATTAAGAACGACGCCACTGCCCAGGCCTTCCTGGCTGAAGCCTCAGTCATG
ACGCAACTGCGGCATAGCAACCTGGTGCAGCTCCTGGGCGTGATCGTGGAGGAGAAGGGC
GGGCTCTACATCGTCACTGAGTACATGGCCAAGGGGAGCCTTGTGGACTACCTGCGGTCT
AGGGGTCGGTCAGTGCTGGGCGGAGACTGTCTCCTCAAGTTCTCGCTAGATGTCTGCGAG
GCCATGGAATACCTGGAGGGCAACAATTTCGTGCATCGAGACCTGGCTGCCCGCAATGTG
CTGGTGTCTGAGGACAACGTGGCCAAGGTCAGCGACTTTGGTCTCACCAAGGAGGCGTCC
AGCACCCAGGACACGGGCAAGCTGCCAGTCAAGTGGACAGCCCCTGAGGCCCTGAGAGAG
AAGAAATTCTCCACTAAGTCTGACGTGTGGAGTTTCGGAATCCTTCTCTGGGAAATCTAC
TCCTTTGGGCGAGTGCCTTATCCAAGAATTCCCCTGAAGGACGTCGTCCCTCGGGTGGAG
AAGGGCTACAAGATGGATGCCCCCGACGGCTGCCCGCCCGCAGTCTATGAAGTCATGAAG
AACTGCTGGCACCTGGACGCCGCCATGCGGCCCTCCTTCCTACAGCTCCGAGAGCAGCTT
GAGCACATCAAAACCCACGAGCTGCACCTGTGA
GenBank Gene IDX60114
GeneCard IDNone
GenAtlas IDCSK
HGNC IDHGNC:2444
Chromosome Location15
Locus15q23-q25
References
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